3,438 results match your criteria: "Hirosaki University Graduate school of medicine[Affiliation]"
Correction: Sato et al. Safety of Boron Neutron Capture Therapy with Borofalan(B) and Its Efficacy on Recurrent Head and Neck Cancer: Real-World Outcomes from Nationwide Post-Marketing Surveillance. 2024, , 869.
Cancers (Basel)
September 2024
BNCT Joint Clinical Institute, Osaka Medical and Pharmaceutical University, 2-7 Daigaku-machi, Takatsuki 569-8686, Japan.
The authors wish to make the following corrections to this paper [...
View Article and Find Full Text PDFImpact of prior hospitalization for heart failure on clinical outcomes of patients after transcatheter aortic valve implantation with new-generation devices: Insights from the LAPLACE-TAVI registry.
Catheter Cardiovasc Interv
December 2024
Department of Cardiology, Kawasaki Saiwai Hospital, Kawasaki, Japan.
Article Synopsis
- A history of hospitalization for heart failure (HHF) before transcatheter aortic valve implantation (TAVI) is linked to poorer clinical outcomes in patients with severe aortic stenosis (AS).
- In a study of 2,752 patients, those with prior HHF had significantly higher 30-day mortality and overall risk of negative outcomes compared to those without such a history.
- The findings highlight that prior HHF affects patients regardless of their heart function, emphasizing the need for careful evaluation and management in these cases post-TAVI.
Incidence and Predictors of Appropriate Implantable Cardioverter Defibrillator Therapy in Japanese Ischemic Heart Disease Patients.
Circ J
October 2024
Department of Cardiology and Nephrology, Hirosaki University Graduate School of Medicine.
Article Synopsis
- The study investigated the effectiveness of implantable cardioverter defibrillators (ICDs) in Japanese patients with ischemic heart disease (IHD), focusing on the incidence and predictors of appropriate ICD therapy.
- A total of 141 IHD patients were followed for an average of 5.5 years, revealing similar rates of appropriate ICD therapy between primary and secondary prevention groups, with a notable increase in the secondary group during the first two years.
- The analysis identified sustained ventricular tachycardia (VT) as a key predictor of receiving appropriate ICD therapy, highlighting the importance of monitoring patients closely, especially in the high-risk period following their first treatment.
Effectiveness and Safety of Matrix-Associated Autologous Chondrocyte Implantation for the Treatment of Articular Cartilage Defects: A Real-World Data Analysis in Japan.
Am J Sports Med
November 2024
Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki City, Aomori Prefecture, Japan.
Article Synopsis
- The study investigates the effectiveness and safety of matrix-associated autologous chondrocyte implantation with an autologous periosteal flap (pMACI) for treating large cartilage defects in the knee.
- Data were analyzed from 232 knees in 225 patients, focusing on outcomes such as the Lysholm knee score and KOOS at different follow-up intervals.
- The findings showed that a significant percentage of patients reported meaningful improvements in knee function and symptoms, with higher success rates in those who did not undergo additional surgeries like microfracture.
Polygonum tinctorium extract suppresses the virulence of methicillin-resistant Staphylococcus aureus by disrupting its extracellular vesicles.
J Ethnopharmacol
January 2025
Department of Biopolymer and Health Science, Hirosaki University Graduate School of. Medicine, Hirosaki, Aomori, Japan. Electronic address:
Article Synopsis
- MRSA is a major health threat globally, and the study focuses on how the extract from the plant Polygonum tinctorium (Indigo Ex) may affect the extracellular vesicles released by S. aureus (SaEVs), which are important for bacterial survival and infection.
- The researchers prepared Indigo Ex from pesticide-free P. tinctorium and investigated its impact on the structure and immune response of SaEVs using advanced microscopy and cell assays.
- Results indicated that Indigo Ex disrupts SaEVs and reduces their cytotoxicity, showing potential for controlling MRSA infections by decreasing inflammatory responses in immune cells.
A phase II study of daily carboplatin plus irradiation followed by durvalumab therapy for older adults (≥75 years) with unresectable III non-small-cell lung cancer and performance status of 2: NEJ039A.
ESMO Open
October 2024
Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan.
Article Synopsis
- The study investigates the effectiveness of durvalumab, an immunotherapy drug, after chemoradiotherapy in patients with unresectable locally advanced non-small-cell lung cancer (LA-NSCLC), particularly those with poorer performance status or older age.
- In a phase II trial with 86 participants, 61 received durvalumab after low-dose carboplatin and radiotherapy, showing a 12-month progression-free survival (PFS) rate of 51%, exceeding the expected 35%.
- The treatment was deemed effective, with a median overall survival of 28.1 months, but pneumonitis was noted as the most common severe side effect.*
Association between Immune-Related Adverse Events and Atezolizumab in Previously Treated Patients with Unresectable Advanced or Recurrent Non-Small Cell Lung Cancer.
Cancer Res Commun
November 2024
Kindai Hospital Global Research Alliance Center and Thoracic Surgery, Kindai University, Osaka, Japan.
Article Synopsis
- The study aimed to investigate the relationship between immune-related adverse events (irAEs) and the effectiveness of immune checkpoint inhibitor therapy in cancer patients, particularly focusing on overall and progression-free survival.
- In a cohort of 1,002 Japanese patients with advanced non-small cell lung cancer treated with atezolizumab, 19% experienced irAEs, predominantly skin disorders and interstitial lung disease.
- Results showed that patients with irAEs had better overall survival compared to those without, especially those with low-grade irAEs, indicating potential clinical benefits from irAEs in real-world settings, except for high-grade events unrelated to skin or endocrine disorders.
Clinical significance of PSA dynamics in castration-sensitive prostate cancer treated with ARSI doublet therapy: A multicenter study.
Urol Oncol
October 2024
Department of Urology, The Jikei University School of Medicine, Tokyo, Japan.
Article Synopsis
- Androgen receptor signaling inhibitors (ARSIs) have significantly improved the treatment of metastatic castration-sensitive prostate cancer (mCSPC) by influencing prostate-specific antigen (PSA) dynamics, which are critical for assessing disease control.
- A retrospective study involving 552 mCSPC patients was conducted to analyze the impact of PSA nadir, PSA response rate, and time to PSA nadir on oncological outcomes like cancer-specific survival and overall survival.
- Results indicated that achieving a low PSA nadir (≤ 0.02 ng/mL) and a high PSA response rate (≥ 99%) were strong independent predictors of better clinical outcomes, underscoring the importance of monitoring PSA dynamics in patient treatment.
Successful treatment of Bothnian-type palmoplantar keratoderma using the etretinate and goreisan combination.
J Dermatol
January 2025
Department of Dermatology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Reproductive organ involvement in women undergoing radical cystectomy for urothelial bladder cancer: a nationwide multicenter study.
Int J Clin Oncol
December 2024
Department of Urology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, Japan.
Article Synopsis
- This study looked at women with bladder cancer who had surgery to remove their bladder and other reproductive organs to see how many still had problems with their reproductive organs.
- Out of 417 women, some had their uterus and vaginal wall saved, but about 9% showed signs of cancer in their reproductive areas.
- The researchers concluded that doctors need to think carefully about whether to save these organs during surgery because there's a risk that cancer could still affect them.
Highly sensitive and accurate detection of ALK-TKI resistance mutations by oligoribonucleotide interference-PCR (ORNi-PCR)-based methods.
Lung Cancer
November 2024
Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562 Aomori, Japan. Electronic address:
Article Synopsis
- - Patients with ALK-positive non-small cell lung cancer often benefit from ALK tyrosine kinase inhibitors, but resistance mutations commonly lead to cancer recurrence, highlighting the need for early detection methods.
- - This study aimed to develop a highly sensitive and cost-effective technique using oligoribonucleotide interference-PCR (ORNi-PCR) combined with droplet digital PCR (ddPCR) to detect common ALK-TKI resistance mutations (G1202R and L1196M) in cell-free DNA from patients.
- - The results showed that ORNi-PCR successfully identified as few as 1-10 copies of the resistance mutations in model samples and patient samples, outpacing conventional methods, which could enhance early detection of resistant NSCLC.*
Biomarker-Based Approach to α-Synucleinopathies: Lessons from Neuropathology.
Mov Disord
December 2024
Banner Sun Health Research Institute, Sun City, Arizona, USA.
[Appropriate use of blood components].
Rinsho Ketsueki
October 2024
Department of Transfusion and Cell Therapy Medicine, Hirosaki University Graduate School of Medicine.
Blood products are biological products derived from human blood. Japan currently meets its domestic needs with red cell products, platelet products, and plasma derivatives produced from blood, but this system could face challenges in the future. Blood transfusion therapy is only a replacement therapy that relieves symptoms, and should not worsen the patient's outcome.
View Article and Find Full Text PDFRetrospective analysis of treatment-positioning accuracy and dose error in boron neutron capture therapy using a sitting-position treatment system for head and neck cancer.
Phys Med
October 2024
Department of Radiation Oncology, Southern Tohoku BNCT Research Center, 7-10 Yatsuyamada, Koriyama, Fukushima, 963-8052, Japan.
The neutron beam in boron neutron capture therapy (BNCT) exhibits poor directionality and significantly decreasing neutron flux with increasing distance. Therefore, the treatment site must be close to the irradiation aperture. Some patients with head and neck cancer may benefit from a sitting-position setup.
View Article and Find Full Text PDFImpact of Cachexia and First-Line Systemic Therapy for Previously Untreated Advanced Non-Small Cell Lung Cancer: NEJ050A.
J Cachexia Sarcopenia Muscle
December 2024
Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Article Synopsis
- Cancer cachexia frequently occurs in advanced non-small cell lung cancer (NSCLC) and its impact on chemotherapy is not fully understood.
- A study involving 887 NSCLC patients identified that 31.7% experienced weight loss indicative of cachexia, with variations in quality of life (QOL) observed across different treatment groups.
- Results showed that quality of life declined more significantly in chemotherapy patients compared to those receiving targeted therapies or immune checkpoint inhibitors, especially within the first week of treatment.
Fecundity difference is related to the production of reproductive pheromones in rats.
Reproduction
December 2024
Department of Health and Nutritional Sciences, Faculty of Health and Medical Sciences, Aichi Shukutoku University, Nagakute-city, Aichi, Japan.
In Brief: Social and reproductive behaviors in mammals are regulated by pheromones. This study shows the possibility that male extraorbital lacrimal gland-derived pheromones are involved in reproductive efficiency in rats.
Abstract: In rodents, male-derived pheromones play fundamental roles in reproduction.
Prognostic model for second progression-free survival and overall survival in patients with high-risk metastatic hormone-sensitive prostate cancer treated with abiraterone acetate and androgen deprivation therapy.
Prostate
January 2025
Department of Urology, Akita University Graduate School of Medicine, Akita, Japan.
Article Synopsis
- Researchers created and validated a risk model for high-risk metastatic hormone-sensitive prostate cancer (mHSPC) patients treated with abiraterone acetate (ABI) to better predict patient outcomes.
- The study involved 233 patients from three academic centers and validated the model on a separate group of 282 patients, analyzing factors that influence progression-free survival (PFS2) and overall survival (OS).
- Key findings showed that the model effectively categorized patients into risk groups, with poor-risk patients having significantly lower median PFS2 and OS compared to favorable and intermediate groups, aiding in treatment planning.
Nasojejunal Tube Placement for Levodopa-carbidopa Intestinal Gel Treatment by Neurologists in Patients with Advanced Parkinson's Disease: A Retrospective Observational Study.
Intern Med
September 2024
Department of Neurology, Hirosaki University Graduate School of Medicine, Japan.
Introduction Short-term levodopa-carbidopa intestinal gel (LCIG) treatment using nasojejunal (NJ) tubes (NJ-LCIG test) is recommended for patients with advanced Parkinson's disease to ensure compatibility with this treatment system prior to permanent percutaneous endoscopic gastrojejunostomy. However, there have been no studies on NJ tube insertion by neurologists or on possible differences in treatment efficacy based on the NJ tube insertion method or tube tip position. We therefore investigated the effects of LCIG with NJ tube placement performed by a neurologist.
View Article and Find Full Text PDFEpidemiological Study on the Interaction between the (rs738409) and Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease.
Genes (Basel)
September 2024
Department of Gastroenterology, Hematology, and Clinical Immunology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, Japan.
Many factors are associated with the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD); however, genetics and gut microbiota are representative factors. Recent studies have highlighted the link between host genes and the gut microbiota. Although there have been many studies on the separate effects of single nucleotide polymorphisms (SNPs) and gut bacteria on MASLD, few epidemiological studies have examined how SNPs and gut bacteria interact in the development and progression of MASLD.
View Article and Find Full Text PDFIn Reply to Wada and Mori.
Int J Radiat Oncol Biol Phys
November 2024
Department of Radiation Oncology, Hirosaki University Graduate School of Medicine, Japan.
Impact of societal change on anesthesia practice in Japan.
J Anesth
September 2024
Medical Informatics, Hirosaki University Graduate School of Medicine, Hirosaki, 036-8562, Japan.
Optimal treatment strategy for patients with pancreatic cancer having positive peritoneal cytology: A nationwide multicenter retrospective cohort study supervised by the Japanese Society of Hepato-Biliary-Pancreatic Surgery.
J Hepatobiliary Pancreat Sci
September 2024
Japanese Society of Hepato-Biliary-Pancreatic Surgery, Tokyo, Japan.
Background: The aim of this study was to determine the optimal treatment for patients with pancreatic cancer (PaCa) having positive peritoneal cytology (PPC).
Methods: This multicenter retrospective study included patients with PPC treated at 78 high-volume centers between January 2012 and December 2020. Prognoses after resection (S-group) and initiation of nonsurgical treatment (N-group) were compared.
Role of CD34 in calcification of human aortic valve interstitial cells from patients with aortic valve stenosis.
J Pharmacol Sci
November 2024
Department of Vascular and Inflammatory Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, 036-8562, Japan. Electronic address:
Article Synopsis
- The study investigates the role of CD34 in human aortic valve interstitial cells (HAVICs) related to calcified aortic valve stenosis (CAVS), highlighting the complexity of calcification factors involved.
- It was found that CD34-negative HAVICs are more sensitive to calcification stimuli and that the expression of tenascin X (TNX) mRNA significantly decreases in these cells.
- The research suggests that CD34 acts as an inhibitory regulator against valve calcification, particularly by counteracting the effects of inflammatory cytokines like TNF-α and IL-1β, which lower CD34 expression and contribute to increased calcification.
Usefulness of bilateral cerebral regional oxygen saturation measurements in determining selective cerebral perfusion flow rate in a pediatric patient with aortic arch stenosis: a case report.
JA Clin Rep
September 2024
Department of Anesthesiology, Hirosaki University Graduate School of Medicine, 5 Zaifu-Cho, Hirosaki, Aomori, 036-8562, Japan.
Background: We report a pediatric case where bilateral regional oxygen saturation (rSO) measurements were useful in determining the selective cerebral perfusion (SCP) flow rate.
Case Presentation: A 9-year-old Japanese boy, 128 cm tall and weighing 25.6 kg, was scheduled for aortic arch reconstruction due to a 90-100 mmHg pressure gradient.
Stress is simultaneously related to sleep and temporomandibular disorders.
Sleep Breath
December 2024
Department of Oral and Maxillofacial Surgery, Hirosaki University Graduate School of Medicine, Zaifu-cho Hirosaki city, 036-8562, Aomori Prefecture, Japan.
Article Synopsis
- - This study examined how the oral environment and psychological factors like stress affect sleep quality, particularly in relation to temporomandibular disorders (TMDs).
- - Data from 1,032 participants were analyzed using multiple regression to explore connections between TMDs, stress, and sleep quality measured by the Pittsburgh Sleep Quality Index (PSQI).
- - The results indicated a strong link between TMDs and stress as factors contributing to poor sleep quality, suggesting that mental stress may lead to both sleep issues and TMD symptoms.