Myotoxicity of local anesthetics is equivalent in individuals with and without predisposition to malignant hyperthermia.

Purpose: Malignant hyperthermia (MH) is an inherited muscle disorder caused by abnormal elevations of intracellular calcium (Ca) in skeletal muscle. There are several reports of myotoxicity caused by local anesthetics, and the increased intracellular Ca is considered to be an important cause. However, there is insufficient evidence regarding myotoxicity in MH-susceptible individuals when large doses of local anesthetics are administered.