12 results match your criteria: "Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine.[Affiliation]"

Background: High psychological resilience is associated with improved functional outcomes for older adults recovering from hip fracture. The objective of this study was to identify factors associated with increased psychological resilience in older women after hip fracture.

Methods: 129 women aged ≥65 years with recent surgically-repaired hip fracture were enrolled in a trial of exercise and testosterone therapy.

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Enabling osteoporosis treatment in post-acute care: An algorithm for providers.

Geriatr Nurs

November 2024

Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Hebrew SeniorLife, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

Approximately 60 % of older adults with a hospitalized fracture receive post-acute care in a skilled nursing facility (SNF), yet fewer than 10-20 % receive osteoporosis treatment following a fracture. This study sought to understand SNF providers' perspectives on osteoporosis treatment and to receive feedback on a pocketcard to guide osteoporosis treatment in the post-acute care setting. We interviewed 17 SNF providers with 2+ years of post-acute care experience from 13 states.

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Pre-procedural nursing home length of stay and outcomes of transcatheter aortic valve replacement.

J Am Geriatr Soc

November 2024

Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Hebrew Senior Life & Harvard Medical School, Boston, Massachusetts, USA.

Background: Older adults with severe aortic stenosis (AS) may receive care in a nursing home (NH) prior to undergoing transcatheter aortic valve replacement (TAVR). NH level of care can be used to stabilize medical conditions, to provide rehabilitation services, or for long-term care services. Our primary objective is to determine whether NH utilization pre-TAVR can be used to stratify patients at risk for higher mortality and poor disposition outcomes at 30 and 365 days post-TAVR.

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Evaluating Lecanemab Eligibility for Patients in Skilled Nursing Facilities With Alzheimer Disease or Mild Cognitive Impairment.

J Am Med Dir Assoc

November 2024

Department of Health Services, Policy, and Practice, Brown University School of Public Health, Providence, RI, USA; Alzheimer's Disease and Memory Disorders Center at Rhode Island Hospital, Providence, RI, USA; Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI, USA.

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Aim: Studies examining the safety and effectiveness of sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus glucagon-like peptide-1 receptor agonists (GLP-1RAs) among community-dwelling adults may not generalize to nursing home (NH) residents, who are typically older and more multimorbid. We compared the safety and cardiovascular effectiveness of SGLT2is and GLP-1RAs among US NH residents.

Materials And Methods: Eligible individuals were aged ≥66 years with type 2 diabetes mellitus and initiated an SGLT2i or GLP-1RA in an NH between 2013 and 2018.

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Background: Opioids are recommended for pain management in patients being cared for and transported by emergency medical services, but no specific guidelines exist for older adults with fall-related injury. Prior research suggests prehospital opioid administration can effectively manage pain in older adults, but less is known about safety in this population. We compared short-term safety outcomes, including delirium, disposition, and length of stay, among older adults with fall-related injury according to whether they received prehospital opioid analgesia.

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Article Synopsis
  • The search for biomarkers that measure biological aging, especially 'omic'-based ones, has gained momentum, aiming to predict aging outcomes and assess interventions for healthy aging.
  • There is currently no agreement on the best methods to validate these aging biomarkers before using them in clinical settings.
  • The review emphasizes the need for systematic validation, which can enhance the reliability and effectiveness of aging biomarkers in clinical research and trials focused on longevity.
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Fall risk and cardiovascular outcomes of first-line antihypertensive medications in nursing home residents.

J Am Geriatr Soc

March 2024

Department of Health Services, Policy, and Practice & Center for Gerontology, Brown University School of Public Health, Providence, Rhode Island, USA.

Article Synopsis
  • The study examined the effects of first-line antihypertensive medications (RAASi, amlodipine, and thiazide diuretics) on the rates of falls and cardiovascular events in older adults in nursing homes with limited life expectancy.
  • A total of 16,504 patients were analyzed, with a follow-up period averaging 5.3 months, revealing that 2% had injurious falls, 9.6% experienced major cardiovascular events, and 12.9% died during that time.
  • Results indicated that the rates of falls and cardiovascular events did not significantly differ among medication types, although thiazides were more frequently discontinued compared to the others.
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Performance of FRAX in older adults with frailty: the Framingham Heart Study.

Osteoporos Int

February 2024

Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Hebrew SeniorLife, 1200 Centre Street, Boston, MA, 02131, USA.

Article Synopsis
  • The study evaluated how well the FRAX tool predicts major osteoporotic fractures (MOFs) in 3,554 participants from the Framingham Study, focusing on differences between individuals with frailty and those without. !* -
  • Overall, participants with frailty had a higher rate of MOFs (6.9%) compared to those without frailty (3.0%), but the FRAX tool's predictive accuracy was lower for frail individuals, especially when not including bone mineral density (BMD) measurements. !* -
  • Including BMD in the FRAX assessment improved its prediction capabilities for frail individuals, indicating that while FRAX can be useful, it tends to overestimate fracture risk, particularly for
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Background: Medication optimization, including prescription of osteoporosis medications and deprescribing medications associated with falls, may reduce injurious falls. Our objective was to describe a remote, injury prevention service (NH PRIDE) designed to optimize medication use in nursing homes (NHs), and to describe its implementation outcomes in a pilot study.

Methods: This was a non-randomized trial (pilot study) including NH staff and residents from five facilities.

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Retention and Resilience of Nursing Home Staff During the COVID-19 Pandemic: Voices from the Frontline.

J Am Med Dir Assoc

October 2023

Hinda and Arthur Marcus Institute for Aging Research and Department of Medicine, Hebrew SeniorLife, Boston, MA, USA; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

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