Reimplantation of cultivated human bone cells from the posterior maxilla for sinus floor augmentation. Histological results from a randomized controlled clinical trial.

Objectives: The aim of the present randomized clinical study was to evaluate histologically whether the addition of cultivated, autogenous bone cells to a composite graft of deproteinized bovine bone mineral (DBBM) and autogenous bone (AB) for sinus floor augmentation (SFA) enhance bone formation compared with what achieved after SFA with DBBM + AB alone.

Material And Methods: Twenty patients with remaining posterior maxillary alveolar crest height of less than 3 mm received SFA after randomization either with an DBBM and AB composite in a 1 : 1 ratio or with DBBM + AB supplemented with autogenous bone cells, which were cultivated from a bone biopsy harvested earlier from the tuberosity area. Four months after SFA, two cylindrical biopsies were taken from the augmented sinuses concomitantly with the implant site preparation by means of a trephine bur.

The addition of lidocaine to bupivacaine does not shorten the duration of spinal anesthesia: a randomized, double-blinded study of patients undergoing knee arthroscopy.

Background: The duration of spinal anesthesia with bupivacaine is often too long for day surgery. A recent study of patients presenting for transurethral surgery suggested that the addition of a small amount of lidocaine to intrathecal hyperbaric bupivacaine could shorten the duration of the sensory and motor blocks. In this prospective, randomized double-blind study we investigated these findings in patients undergoing unilateral knee arthroscopy.

Clinically isolated laryngeal sarcoidosis.

Laryngeal sarcoidosis is rare (0.5% of patients with sarcoidosis), the pathogenesis is unknown and the optimal treatment remains a matter of debate. We undertook this study to elucidate possible pathogenic factors in clinically isolated laryngeal sarcoidosis and to describe results of supraglottoplastic surgery.

Accuracy of combined maxillary and mandibular repositioning and of soft tissue prediction in relation to maxillary antero-superior repositioning combined with mandibular set back A computerized cephalometric evaluation of the immediate postsurgical outcome using the TIOPS planning system.

Aim: The purpose of the present study was to evaluate the immediate postsurgical outcome of planned and predicted hard and soft tissue positional changes in relation to maxillary antero-superior repositioning combined with mandibular set back using the computerized, cephalometric, orthognathic surgical planning system (TIOPS).

Material And Methods: Out of 100 prospectively and consecutively treated patients, 52 patients manifested dentofacial deformities requiring bimaxillary orthognathic surgery with maxillary antero-superior repositioning combined with mandibular set back and so were included. All patients were managed with rigid internal fixation (RIF) and without intermaxillary fixation (IMF).

Implementation of a new rapid tissue processing method--advantages and challenges.

Conventional tissue processing of histologic specimens has been carried out in the same manner for many years. It is a time-consuming process involving batch production, resulting in a 1-day delay of the diagnosis. Microwave-assisted tissue processing enables a continuous high flow of histologic specimens through the processor with a processing time of as low as 1h.

Validation of the Stroke Specific Quality of Life Scale (SS-QOL): test of reliability and validity of the Danish version (SS-QOL-DK).

Objective: To test the reliability and validity of the Danish version of the Stroke Specific Quality of Life Scale version 2.0 (SS-QOL-DK), an instrument for evaluation of health-related quality of life.

Design: A correlational study.

Assessment and clinical aspects of health-related quality of life in dialysis patients and patients with chronic kidney disease.

Background/aims: It is relevant to investigate health-related quality of life (HRQOL) in dialysis and chronic kidney disease (CKD) patients in order to optimise treatment. The aim of this study was to investigate HRQOL in dialysis and CKD patients, to compare results from patients treated with hemodialysis (HD) and peritoneal dialysis (PD) and to investigate the prediction of dialysis quality control parameters (blood hemoglobin, plasma albumin, and Kt/V) and tobacco smoking in disease-specific HRQOL.

Methods: Seventy-one HD, 59 PD, and 63 CKD patients participated in the study.

Cognitive function in a cohort of Danish steel workers.

Objective: The aim of this study was to evaluate the level of possible cognitive impairment in a cohort of steel workers occupationally exposed to manganese and lead.

Material: Ninety-two employees from an electro-steel works were examined in 1989 and 1995. Fifty-three were re-examined in 2003.

Efficacy and safety of 24 weeks of therapy with bendroflumethiazide 1.25 mg/day or 2.5 mg/day and potassium chloride compared with enalapril 10 mg/day and amlodipine 5 mg/day in patients with mild to moderate primary hypertension : a multicentre, randomised, open study.

Background: The efficacy and safety of therapy with low-dose bendroflumethiazide 1.25 mg/day or 2.5 mg/day and potassium chloride was compared with that of enalapril 10 mg/day and amlodipine 5 mg/day in patients with mild to moderate primary hypertension.

Heart rate variability and intima media thickness.

Increased activity in the sympathetic nervous system is part of the physiological stress response and is expressed in the heart rate variability (HRV). The objective of this study was to examine associations of HRV and intima media thickness (IMT). In 2002, satisfactory measurements of HRV of 78 voluntary participants were made, both during a stress test and during sleep.

Neuromotor function in a cohort of Danish steel workers.

Objective: With a longitudinal design to evaluate possible neuromotor impairment in a cohort of steel workers exposed to metal dust.

Material: Ninety-two employees from a steel works were examined in 1989 and 1995. Sixty were re-examined in 2003.

Total power and high frequency components of heart rate variability and risk factors for atherosclerosis.

Introduction: Low heart rate variability, HRV, is associated with diabetic neuropathy and with ischemic heart disease, IHD. The time context points to diabetes preceding changes in HRV, while changes in HRV precede the development of atherosclerosis and IHD. The purpose of the study was to analyse the association between the physiological risk factors of IHD and HRV in a prospective design.

Combined central retinal artery and vein occlusion in Churg-Strauss syndrome: case report.

Purpose: To describe a rare case of Churg-Strauss syndrome presenting with severe visual loss due to a combined central retinal vein and artery occlusion.

Methods: A 42-year old man with a medical history of asthma and blood hypereosinophilia developed a sudden loss of vision in his right eye. We describe the clinical features and evolution of the case after treatment.

Psychosocial factors at home and at work and levels of salivary cortisol.

Background: Salivary cortisol as a physiological measure of stress has attracted great interest in recent years.

Method: A 55 women and 28 men, all healthy volunteers, were included in a study on psychosocial factors at work and at home and salivary cortisol. General linear models, univariate and repeated measures, respectively, were used to evaluate the associations between psychosocial factors and cortisol excretion measured six times during a working day.

Stroke Specific Quality of Life Scale: Danish adaptation and a pilot study for testing psychometric properties.

Background And Purpose: Stroke has an effect on many aspects of quality of life (QoL) and therefore it is important to measure the magnitude of the impact. Items in the American version of the Stroke Specific Quality of Life (SS-QoL) Scale are developed with help from patients with stroke and include even language impairments.

Aims: To translate and culturally adapt the American SS-QoL Scale, version 2.

Burden of headache.

Although headache is the most prevalent pain disorder, the substantial societal and individual burden associated with it has been previously overlooked. The primary headaches including migraine, tension-type and cluster are the most prevalent forms but also a very high number of headaches secondary to analgesic overuse and various brain diseases are ignored without any specific acknowledgement or treatment. Migraine is listed as number 20 of all diseases with regard to years lived with disability, and headache accounts for approximately 20% of lost work days.

Ocular anisometropia and laterality.

Purpose: To study the difference in refraction between right and left eyes (anisometropia) in different age groups, look for evidence of eye laterality (more refractive error in one eye) and compare the size of anisometropia in the myopic and emmetropic ranges.

Methods: The study was based on children in Hong Kong (examined at the age of 6 years and again at the age of 8.5 years) and their parents (aged 26-60 years).

False-negative frozen section of sentinel lymph node biopsy for breast cancer.

A prospective study is presented of frozen section examinations (FS) performed in parallel with 265 consecutive sentinel lymph node procedures (SLNP) over a 20-month period. The final pathological study included immunohistochemistry (IHC) for keratin if the haematoxylin-eosin (HE)-stained section was tumour free. FS correctly identified node-positive or node-negative axillae in 235 cases.

The mystery of myopia.

Published data from all parts of the world show that myopia is rare before school age, gradually increases during school life and reaches its highest level of prevalence during the years of most intense study at university. It is widely held that continuous reading harms the eyes, but none of the attempts made so far to reduce accommodative fatigue by introducing pauses during reading and teaching, eye exercises, etc. have been successful in reducing the number of children who develop myopia.

Epidemiology of headache.

Headache disorders constitute a public-health problem of enormous proportions, with an impact on both the individual sufferer and society. Epidemiological knowledge is required to quantitate the significance of these disorders. The effects on individuals can be assessed by examining prevalence, distribution, attack frequency and duration, and headache-related disability.

Bone density and geometric properties of the distal radius in displaced and undisplaced Colles' fractures: quantitative CT in 70 women.

We examined cortical and trabecular bone density and geometric properties of the unfractured distal radius in 70 women with recent Colles' fractures, using multilayer peripheral quantitative computed tomography (pQCT). We found that cortical volumetric density, cortical area and mean cortical thickness were lower in the displaced than in the undisplaced fractures, suggesting that the cross-sectional volumetric density and geometric properties of cortical bone may be essential in determining the severity of a Colles' fracture. We also compared lumbar spine and femoral neck bone mineral density (BMD) and the occurrence of osteoporosis in the displaced and undisplaced fracture groups and found no significant difference, which suggests that displacement of a Colles' fracture is not associated with general osteoporosis.

Validation of a leg-to-leg bioimpedance analysis system in assessing body composition in postmenopausal women.

Objectives: To evaluate the validity of a leg-to-leg bioimpedance analysis (BIA) system in predicting body composition as measured by dual-energy X-ray absorptiometry (DXA) in postmenopausal women.

Subjects And Methods: Body fat mass (FM), %Fat and fat free mass (FFM) were measured in 124 postmenopausal women (age: 51-63 y, body mass index (BMI): 17-38 kg/m2) first by the leg-to-leg BIA system, and then by DXA as reference method. Bland-Altman analysis was used to determine the bias and 95% limits of agreement between the two methods for the assessment of the individual.

Transcutaneous nitroglycerine in the treatment of erectile dysfunction: a placebo controlled clinical trial.

Transcutaneous nitroglycerine has previously been reported to be effective in the treatment of erectile dysfunction. We present our results with the drug in a randomised, placebo controlled, double-blind crossover study. The effect of the drug has been evaluated both under laboratory conditions and in a home study.