IS FECAL CALPROTECTIN DETERMINATION USEFUL FOR PATIENTS WITH METABOLIC ASSOCIATED FATTY LIVER DISEASE?

Objective: Aim: To investigate the possible relationship between fecal calprotectin (FC) level and ultrasound indicators of steatosis and fibrosis wich defined by attenuation coefficient (AC) and liver stiffness (LS) from two-dimensional (2D) shear-wave elastography (SWE) in patients with metabolically associated fatty liver disease (MAFLD).

Patients And Methods: Materials and Methods: The study included 110 persons with MAFLD; mean age 51.3±4.

PREDICTING PROGRESSION TYPE 2 DIABETES MELLITUS: A 3-YEAR FOLLOW-UP STUDY EXAMINING RISK FACTORS FOR TYPE 2 DIABETES IN PATIENTS WITH PREDIABETES.

Objective: Aim: To study the risk factors in patients with prediabetes that can lead to the progression of impaired glucose tolerance in the form of type 2 diabetes mellitus.

Patients And Methods: Materials and methods: The selection of patients for this study was carried out on an outpatient basis at the Department of Therapy and Family Medicine, Uzhhorod National University. Patients with prediabetes were identified based on the American Diabetes Association criteria.

PATIENT MANAGEMENT TACTICS AT DIFFERENT STAGES OF GASTROINTESTINAL STROMAL TUMORS (GIST).

Objective: The aim: To analyze the results of treatment even in limited groups of patients.

Patients And Methods: Materials and methods: Clinical cases of GIST based on the materials of the surgical clinic of the Central Municipal Hospital in Uzhgorod (Transcarpathian region) were discussed. Clinical, ultrasound and CT monitoring was provided.

CLINICAL CASE OF FALLOPIAN TUBE CANCER IN PATIENT OF POSTMENOPAUSAL AGE.

Fallopian tube cancer (FTC) is an extremely rare case in oncogynecological practice with an incidence of 0,14-1,8 % among all malignant diseases of the female genital organs. The lack of specific symptoms, imitation of other malignant gynecological diseases, significant similarity with endometrial and ovarian cancer make FTC a disease that is difficult to diagnose. At the preoperative stage, FTC can be detected in 0 to 21% of cases.

SARS-COVID-19 TRIGGERED WERNICKE'S ENCEPHALOPATHY (CLINICAL CASE).

Patient P., born in 1956, was found by relatives in a state of confused consciousness, an act of involuntary urination and defecation, numbness and weakening of the strength of both lower limbs were recorded. He was taken by ambulance to the reception room of the Regional Clinical Center of Neurosurgery and Neurology.

TREATMENT OF FRACTURES OF THE PROXIMAL TIBIAL METAEPIPHYSIS.

Objective: The aim: Analyze the literature data on the treatment of fractures of the proximal metaphysis of the tibia.

Patients And Methods: Materials and methods: The article used data from domestic and foreign scientific literature. Research methods such as bibliosemantic and information¬al-analytical were applied.

MOTIVATION THEORIES AS THE KEY TO MANAGEMENT OF MEDICAL STAFF.

Objective: The aim: To identify positions that are relevant for practical use in improving the process of human resource management in healthcare.

Patients And Methods: Materials and methods: Comparative analysis of motivation theories.

Conclusion: Conclusions: Human resources are a key intangible resource of a society or any organization.

ETHICAL EXPERTISE OF BIOMEDICAL RESEARCH AS A WAY OF HUMAN RIGHTS PROTECTION.

Objective: The aim: To find out the peculiarities of ethical expertise of biomedical research as a way of human rights protection.

Patients And Methods: Materials and methods: The dialectical method of cognition, based on the epistemological possibilities of the laws and categories of dialectics, provided a study of the formation and activity of bodies and institutions responsible for the ethical examination of biomedical research. Formal and logical methods of analysis and synthesis made it possible to reveal the meaning of the concepts that make up the subject of the study, to carry out their classification, as well as to formulate intermediate and general conclusions.

SOMATIC (PERSONAL) HUMAN RIGHTS: THE RATIO OF MEDICAL AND LEGAL CATEGORIES.

Objective: The aim: To find out the peculiarities of somatic (personal) human rights, while combining the basic principles of medicine and law.

Patients And Methods: Materials and methods: Formal-logical methods of analysis and synthesis allowed to reveal the content of the concepts that make up the subject of research, to classify them, as well as to formulate intermediate and general conclusions. The systematic method allowed to study the role and significance of somatic rights among other human rights and freedoms.

CLINICAL EFFECTIVENESS OF EMPAGLIFLOZIN IN PATIENTS WITH HEART FAILURE.

Objective: The aim: To study the possibilities of increasing the effectiveness of treatment and improving the prognosis of patients with various phenotypes of heart failure when using empagliflozin.

Patients And Methods: Materials and methods: The analysis of the data regarding the results of existing studies evaluating the clinical benefit and safety of empagliflozin in patients with various phenotypes of heart failure has been conducted.

Conclusion: Conclusions: In the EMPA-REG OUTCOME study, empagliflozin has demonstrated the ability to improve cardiorenal outcomes and reduce the risk of hospitalization for heart failure in patients with diabetes.

IMPACT OF DISTANCE EDUCATION ON STUDENTS' HEALTH.

Objective: The aim: Studying the impact of distance learning on students' health.

Patients And Methods: Materials and methods: Special research methods and medical-statistical method. Domestic and foreign students were subject of the study during the online form of education, in connection with Covid-19, poll was made using Google Forms.

BLOOD COAGULATION DISORDERS IN PATIENTS WITH LIVER CIRRHOSIS INFECTED COVID-19.

Objective: The aim: To investigate the features of coagulation homeostasis in patients with liver cirrhosis (LC) in COVID-19 infection.

Patients And Methods: Materials and methods: At the clinical base of the Department of Propaedeutics of Internal Medicine, 32 patients with LC infected with COVID-19 were examined - 1 Group of patients. The study also included 30 patients with LC who were not infected with COVID-19 (2 Group of patients).

T-CRITERION AS A TOOL FOR DETERMINING THE RISK OF COMPLICATIONS OF THE GESTATIONAL PROCESS.

Objective: The aim: To conduct analyses of the course of the gestational process of women who contracted acute hepatitis A before pregnancy in order to predict and prevent obstetric complications and the possibilities of using the t-test for this.

Patients And Methods: Materials and methods: Clinical and statistical analysis of 500 gestational processes of women who suffered from acute hepatitis A before pregnancy, of which 100 cases were included in the main study by randomization.

Results: Results: All pregnant women were divided into two groups - with obstetric complications during childbirth and without pathological obstetric changes during childbirth.

EARLY DIAGNOSIS OF ASYMPTOMIC CHRONIC ISCHEMIA OF THE LOWER EXTREMITIES.

Objective: The aim: To assess the possibility of using a questionnaire and determining the Ankle Brachial Index(ABI) for early diagnosis of asymptomatic ischemia of the lower extremities in patients with various somatic diseases.

Patients And Methods: Materials and methods: The study involved 294 patients who were receiving inpatient treatment at Communal Non-Profit Enterprise «Uzhgorod Central City Clinical Hospital»,Communal Non-Profit Enterprise «Transcarpathian Regional Clinical Hospital» and Communal Non-Profit Enterprise «Uzhgorod District Clinical Hospital». The study was conducted in 36 patients of pulmonological, 52 - neurological, 22 - endocrinological, 28 - rheumatological, 67 - general therapeutic and 89 - surgical patients.

THROMBOLYSIS IN PULMONARY EMBOLISM TREATMENT.

Objective: The aim: To assess the effectiveness of thrombolytic therapy in treatment pulmonary embolism.

Patients And Methods: Materials and methods: The work analyzed the results of the survey and conservative treatment of 284 patients with pulmonary embolism treated in cardiological department in «Uzhgorod Central City Clinical Hospital» during 2019-2022. Patients were divided into two groups: group I - 250 (88%) patients received anticoagulant therapy; group II - 34 (12%) patients received thrombolytic therapy that was then switched to new oral anticoagulants.

VESTIBULAR DYSFUNCTIONS IN CHRONIC BRAIN ISCHEMIA IN THE POST COVID PERIOD.

Objective: The aim: The aim of the study is the clinical-pathogenetic reasoning of vestibular dysfunctions (VD) development against the background of chronic brain ischemia in the presence of degenerative changes in the cervical spine (CS) in the post COVID period.

Patients And Methods: Materials and methods: 82 patients, in the conditions of the clinical base of the Odessa National Medical University in 2019-2021 were examined. Group I with VD against the background of chronic brain ischemia (CBI) at the compensated phase; Group II with VD against the background of CBI at the subcom¬pensated phase (33 men; 49 women), aged from 18 to 55 years.

THE INFLUENCE OF SPELEOTHERAPY ON BRONCHI PASSAGE IN CHILDREN WITH BRONCHIAL ASTHMA USING A PHARMACO-FUNCTIONAL TEST WITH SALBUTAMOL.

Objective: The aim: To investigate the reaction of the bronchi to inhalation of salbutamol in children with different severity of bronchial asthma under the conditions of speleotherapy.

Patients And Methods: Materials and methods: 40 children aged 6-15 years were examined, 20 of them had an intermittent course of the disease, 20 had a mild course, and the children were in the inter-relapse period. Determining the function of external respiration (FER) with a pharmaco-functional test (PFT) with salbutamol was carried out in the dynamics of observation before and after treatment and compared with the indicators of 40 healthy children.

EFFICACY OF COMPREHENSIVE TREATMENT OF NONALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITH PREDIABETES.

Objective: The aim: To evaluate the effectiveness of the proposed treatment recommendations, which included lifestyle changes, as well as the treatment with ursode¬oxycholic acid, rosuvastatin, and omega-3 PUFA, on the severity of cytolytic and cholestatic syndromes in patients with NAFLD and prediabetes.

Patients And Methods: Materials and methods: Fifty-five patients with confirmed prediabetes and concomitant NAFLD underwent a comprehensive clinical examination and were treated with rosuvastatin 10 mg/d, omega-3 PUFA at a dose of 1000 mg/d and ursodeoxycholic acid at a dose of 10 mg/kg/d.

Results: Results: The data obtained after 12 months of proposed treatment revealed a statistically significant improvement of indicators of cytolytic syndrome in patients with prediabetes and NAFLD.

THE DETERMINATION OF THE NEED TO PROVIDE ORTHODONTIC ASSISTANCE TO TEENAGERS IN CONDITIONS OF LIMITED RESOURCES.

Objective: The aim: To substantiate the need for a combination of interdisciplinary approaches to diagnosis, treatment and correction of dento-maxillofacial anomalies of teenagers based on the analysis of the need for orthodontic treatment using the DAI, IOTN, ICON aesthetic indices.

Patients And Methods: Materials and methods: Empirical, epidemiological, clinical, analytical-synthetic, sociological, psychological research methods, questionnaires, dental indexeshave been used in various combinations.

Results: Results: As a result of a clinical examination of 2,260 teenagers (1,096 boys and 1,124 girls), 1,474 individuals have been bselected for orthodontic treatment with the following degree of complexity: mild - in 25 examined (35.

PHYSICAL HEALTH OF FEMALES FROM THE LOWLAND DISTRICTS OF ZAKARPATTIA ACCORDING TO THE METABOLIC LEVEL OF AEROBIC AND ANAEROBIC ENERGY SUPPLY DEPENDING ON THE COMPONENT BODY COMPOSITION.

Objective: The aim: To determine the aerobic and anaerobic productivity of females from the lowland districts of Zakarpattia region, depending on the component composition of body weight.

Patients And Methods: Materials and methods: A comparative analysis of physical health status of females in the post-pubertal period of ontogenesis, was carried out. Physical health status was assessed by indicators of aerobic and anaerobic productivity depending on the component composition of the body, which was determined by impedance measurement.

CHANGES IN SERUM SOMATOSTATIN AND GASTRIN LEVELS IN PATIENTS AFTER CHOLECYSTECTOMY AND GASTROESOPHAGEAL REFLUX DISEASE.

Objective: The aim: To study of changes in the level of serum gastrin (GN) and somatostatin (SST) in patients with GERD after ChECT and determined their characteristics from clinical forms of GERD.

Patients And Methods: Materials and methods: 64 patients with different clinical forms of GERD were examined. The patients with GERD were divide into 2 clinical groups.

INFLAMMATORY RESPONSE AND METABOLIC ADAPTATION IN CHILDREN WITH ACUTE RESPIRATORY PATHOLOGY.

Objective: The aim: To investigate the parameters change of the general immune responds and endocrine metabolism in the children with Acute Respiratory Pathology and their correlational relationship.

Patients And Methods: Materials and methods: The study group included: school-age children (10-14 years old) with a diagnosis of acute respiratory disease (ARI) as a general group of respiratory tract inflammatory diseases, of viral and bacterial origin (n=40), which included local inflammatory lesions of the respiratory tract and presented with acute pharyngitis (60.0%), acute bronchitis (20%), acute tonsillitis (22%) and a control group (n=25), identical in age and sex.

THE BASIS FOR PROVIDING QUALITY MEDICAL SERVICES AT THE STAGE OF REHABILITATION TREATMENT FOR PATIENTS WITH ASTHMA.

Objective: The aim: To analyze the quality of medical services provided to asthma patients as the stage of rehabilitation treatment and their legal support.

Patients And Methods: Materials and methods: A total 237 patients with asthma were examined on the basis of the SDC "Rehabilitation" of the Ministry of Health of Ukraine in Uzhhorod which has an accreditation. All patients were divided into three groups, depending on the type of rehabilitation treatment.