Environmental impact of the launch vehicle "Soyuz-FG" emergency falling in Kazakhstan.

On October 11, 2018, in the Ulytau region of the Republic of Kazakhstan, the Soyuz-FG launch vehicle carrying a crewed MS-10 spacecraft failed. It resulted in the release into the fragile arid ecosystems of rocket propellants, i.e.

Synthesis of New Promising BNCT Agents Based on Conjugates of -Dodecaborate Anion and Aliphatic Diamino Acids.

In this work, a series of boronated amidines based on the -dodecaborate anion and amino acids containing an amino group in the side chain of the general formula [BHNHC(NH(CH)CH(NH)COOH)CH], where n = 2, 3, 4, were synthesized. These derivatives contain conserved α-amino and α-carboxyl groups recognized by the binding centers of the large neutral amino acid transporter (LAT) system, which serves as a target for the clinically applied BNCT agent para-boronophenylalanine (BPA). The paper describes several approaches to synthesizing the target compounds, their acute toxicity studies, and tumor uptake studies in vivo in two tumor models.

Exploring the Link Between Interoception and Symptom Severity in Premature Ventricular Contractions.

: The physiological basis underlying symptomatic versus asymptomatic premature ventricular contractions (PVCs) remains poorly understood. However, symptomatic PVCs can significantly impair quality of life. In patients without structural heart disease, symptom intensity is crucial for guiding management strategies and determining the need for medical or surgical intervention.

The Replicability Crisis and Human Agency in the Neo-Structured World.

The paper analyzes current discussions concerning the so called "replicability crisis" - a notion describing difficulties in attempts to confirm existing research findings by their additional scrutiny or by new empirical studies. We propose interpretation that this "crisis" may be seen as a manifestation of the increasing inconsistency between, on the one hand, the outdated views on a human being and social structures dominating in the academic mainstream across various disciplines, including psychology and sociology, and, on the other hand, the reality of the emerging new stage of societal evolution, neo-structuration, which brings to the forefront individual agency. Our analysis suggests the possibilities for the future inter-disciplinary paradigmatic shift, which implies putting in the center of research not the idea of a constant or predictably developing individual in the context of solid external structures operating in line with a presumably sustainable "progress".

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats.

Introduction: Aggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain. Ablation of 5-HT biosynthesis by tryptophan hydroxylase 2 knockout (TPH2-KO) increases aggression in rodents.

Novel automated method to assess group dynamics reveals deficits in behavioral contagion in rats with social deficits.

Behavioral copying is a key process in group actions, but it is challenging for individuals with autism spectrum disorder (ASD). We investigated behavioral contagion, or instinctual replication of behaviors, in Krushinky-Molodkina (KM) rats ( = 16), a new potential rodent model for ASD, compared to control Wistar rats ( = 15). A randomly chosen healthy Wistar male ("demonstrator rat") was introduced to the homecage of experimental rats ("observers") 10-14 days before the experiments to become a member of the group.

Association between atherosclerosis and the development of multi-organ pathologies.

Atherosclerosis is a chronic inflammatory disease affecting the vascular system, characterised by the accumulation of modified lipoproteins, immune cell aggregation and the development of fibrous tissue within blood vessel walls. As atherosclerosis impacts blood vessels, its adverse effects may manifest across various tissues and organs. In this review, we examine the association of atherosclerosis with Alzheimer's disease, stroke, pancreatic and thyroid dysfunction, kidney stones and chronic kidney diseases.

FeCl-Mediated Rearrangement of Aminoperoxides into Functionalized Tetrahydrofurans: Dynamic Non-innocence of O-Ligands at an Fe Center Coordinates a Radical Cascade.

The selective reaction of cyclic aminoperoxides with FeCl proceeds through a sequence of O-O and C-C bond cleavages, followed by intramolecular cyclization, yielding functionalized tetrahydrofurans in 44-82% yields. Replacing the peroxyacetal group in the peroxide structure with a peroxyaminal fragment fundamentally alters the reaction pathway. Instead of producing linear functionalized ketones, this modification leads to the formation of hard-to-access substituted tetrahydrofurans.

EuPtPb and SrPtPb-lead-based intermetallics with YRhSn/NdRhSn-type polyanionic platinum-lead 3D frameworks.

Two platinide plumbides, EuPtPb and SrPtPb, were discovered using high-temperature exploratory synthesis and flux-assisted crystal growth. Their crystal structures were determined from single-crystal X-ray diffraction. Both compounds crystallize in the orthorhombic system; EuPtPb belongs to the YRhSn structure type (2, = 4.

The baby duck syndrome as cognitive bias in user-interface interaction.

As technological interfaces are relatively new cultural tools, regular interaction can lead to new psychological phenomena, like the baby duck syndrome, where users favor old interfaces over updates. This syndrome is seen as a cognitive bias in human-computer interaction. Two studies were conducted: Study 1 on an Airbnb app (old vs.

α effect in three-dimensional vortex of conducting rotating liquid.

We study one-point statistics of helical turbulent pulsations in the background of a three-dimensional large-scale vortex in a rotating fluid. Assuming that the helical flow is created by a statistically axially symmetric random force with broken mirror symmetry, we analytically calculate the velocity-vorticity mean including its magnitude and the anisotropy. For electrically conducting liquid, we examine the α-effect in the system.

Pivotal Role of the Intracellular Microenvironment in the High Photodynamic Activity of Cationic Phthalocyanines.

To investigate the influence of phthalocyanine aggregation on their photodynamic activity, a series of six cationic water-soluble zinc(II) phthalocyanines bearing from four to sixteen 4-((diethylmethylammonium)methyl)phenoxy substituents was synthesized. Depending on their structure, the phthalocyanines have different aggregation behaviors in phosphate buffer solutions ranging from fully assembled to monomeric states. Remarkably, independent of aggregation in buffer, very high photodynamic efficiencies against the tumor cell lines MCF-7 and MDA-MB-231 in the nanomolar range were found for all investigated phthalocyanine, and the IC(light) varied from 27 to 358 nM (3.

Evaluating the Effect of Climate on Viral Respiratory Diseases Among Children Using AI.

: Respiratory viral infections (RVIs) exhibit seasonal patterns influenced by biological, ecological, and climatic factors. Weather variables such as temperature, humidity, and wind impact the transmission of droplet-borne viruses, potentially affecting disease severity. However, the role of climate in predicting complications in pediatric RVIs remains unclear, particularly in the context of climate-change-driven extreme weather events.

The role of Epsins in atherosclerosis: From molecular mechanisms to therapeutic applications.

Atherosclerosis is a multifaceted disease characterised by chronic inflammation and vascular remodelling, leading to plaque formation and cardiovascular complications. Recent evidence highlights the critical role of epsins, a family of endocytic proteins, in the pathogenesis of atherosclerosis. This manuscript explores the multifarious functions of epsins in atherosclerosis, focusing on their involvement in angiogenesis, lymphangiogenesis, and the modulation of key signalling pathways.

Photoluminescent chain-of-dimer anion in a novel hybrid halometallate (CHN){SbBr}: atypical behavior in one-dimensional anionic systems.

In pursuit of identifying less toxic hybrid compounds suitable for optoelectronic applications, we synthesized a novel homopiperazinium bromoantimonate(III), (CHN){SbBr}. It readily crystallized from an aqueous hydrobromic acid solution and was found to be stable both in air and upon heating up to 175 °C. The crystal structure of the new bromoantimonate(III) consisted of {SbBr} zigzag chains, which were composed of strongly trigonally distorted SbBr octahedral anions and CHN dications.

Linguacodus: a synergistic framework for transformative code generation in machine learning pipelines.

In the ever-evolving landscape of machine learning, seamless translation of natural language descriptions into executable code remains a formidable challenge. This article introduces Linguacodus, an innovative framework designed to tackle this challenge by deploying a dynamic pipeline that iteratively transforms natural language task descriptions into code through high-level data-shaping instructions. The core of Linguacodus is a fine-tuned large language model, empowered to evaluate diverse solutions for various problems and select the most fitting one for a given task.

Boris Parygin' Social Psychology: History and Perspectives.

International literature on the history of Russian psychology is largely limited to the development of Activity theory and cultural-historical theory. This paper aims to go beyond these limits by introducing a figure little known to an international audience, Boris Parygin, who emerged in the 1960s with his "grand" project for the development of Russian social psychology, significantly different from the Soviet psychology "mainstream," stemming from Vygotsky, Luria, and Alexei Nikolaevich Leontiev. We demonstrate that Parygin's works belong to a theoretical and methodological tradition of social and humanitarian scholarship that had been developing in Russia since 1870s.

Bilingualism, sleep, and cognition: An integrative view and open research questions.

Sleep and language are fundamental to human existence and have both been shown to substantially affect cognitive functioning including memory, attentional performance, and cognitive control. Surprisingly, there is little-to-no research that examines the shared impact of bilingualism and sleep on cognitive functions. In this paper, we provide a general overview of existing research on the interplay between bilingualism and sleep with a specific focus on executive functioning.

[The online literacy of Russian citizen in issues of health information: psychometric characteristics of Russian version of eHEALS].

Nowadays, online environment is the main source of health information. The purpose of the study was twofold and supposed, firstly, adaptation of Russian version of the eHealth Literacy Scale (eHEALS), and secondly, analysis of relationship between eHEALS scores and indications of critical thinking and phenomena of cyber environment (doom-scrolling, cyberchondria and social networks dependence) among Russians. The sampling consisted of 1,025 respondents.

Revitalizing faith: an inquiry into political Sufism and religious continuity in contemporary Kazakhstan.

The article embarks upon a study of political Sufism in contemporary Kazakhstan and patterns of religious continuity through an examination of Islamic manifestations that stretch back centuries, juxtaposed with the current state religious policy. It examines the role of the Muftiate's "official Islam" in shaping the life of religious communities, exploring the intricate interplay between religious identity, secularism, and public perception in the post-Soviet landscape. The author employed a multi-faceted research approach, integrating historical analysis, policy examination, and an ethnographic study of contemporary religious dynamics in the country.

Ruijsenaars wavefunctions as modular group matrix coefficients.

We give a description of the Hallnäs-Ruijsenaars eigenfunctions of the 2-particle hyperbolic Ruijsenaars system as matrix coefficients for the order 4 element acting on the Hilbert space of (2) quantum Teichmüller theory on the punctured torus. The (2) Macdonald polynomials are then obtained as special values of the analytic continuation of these matrix coefficients. The main tool used in the proof is the cluster structure on the moduli space of framed (2)-local systems on the punctured torus, and an -equivariant embedding of the (2) spherical DAHA into the quantized coordinate ring of the corresponding cluster Poisson variety.

A comprehensive review and meta-analysis of CTC isolation methods in breast cancer.

The application of circulating tumor cells (CTCs) as diagnostic and prognostic markers in oncology is gaining increasing importance in clinical practice. Currently, various methods exist for detecting CTCs in patients' biological fluids. This systematic review aimed to compare the efficacy of different techniques for isolating and detecting CTCs from blood, against the FDA-cleared CellSearch® technology, in breast cancer patients.

Matrikines of Sea Cucumbers: Structure, Biological Activity and Mechanisms of Action.

Matrikines (MKs), the products of enzymatic fragmentation of various extracellular matrix (ECM) proteins, regulate cellular activity by interacting with specific receptors. MKs affect cell growth, proliferation, and migration, can induce apoptosis and autophagy, and are also effectively used in biomedicine and functional nutrition. Recently, there has been great interest in the structural features and biological activity of MKs from various sources.