3 results match your criteria: "High Technology Research and Application Centre (YUTAM)[Affiliation]"
Expression of Human β-defensin 2 (hBD-2) in Pichia Pastoris and Investigation of Its Binding Efficiency with ACE-2.
Protein J
August 2023
Faculty of Science, Molecular Biology and Genetics Department, Erzurum Technical University, Erzurum, Turkey.
Article Synopsis
- COVID-19 continues to impact the world, with the innate immune system playing a crucial role in the severity of the disease.
- Antimicrobial peptides (AMPs), particularly human β-defensin 2 (hBD-2), are being studied for their potential to combat pathogens, including viruses like SARS-CoV-2.
- The study involved cloning hBD-2 in yeast and confirming its expression, followed by an analysis of its interaction with the human ACE-2 protein, suggesting hBD-2's potential role in COVID-19 treatment, pending further research.
Effects of four antibiotics on Pseudomonas aeruginosa motility, biofilm formation, and biofilm-specific antibiotic resistance genes expression.
Diagn Microbiol Infect Dis
July 2023
Department of Molecular Biology and Genetics, Erzurum Technical University, Faculty of Science, Erzurum, Turkey; Erzurum Technical University, High Technology Research and Application Centre (YUTAM), Molecular Microbiology Laboratory, Erzurum, Turkey. Electronic address:
The aim of this study was to determine the effects of 4 antibiotics (tobramycin, fosfomycin, ciprofloxacin, and piperacillin/tazobactam) against Pseudomonas aeruginosa motility, biofilm formation, and biofilm resistance gene expression changes using different methods including microscopy, microdilution, crystal violet staining, and qRT-PCR. Although the antibiotics reduced swarming motility, they inhibited biofilm formation to a greater extent than the minimum inhibitory concentration (MIC) value. The qRT-PCR results showed that the antibiotics, other than fosfomycin, decreased the expression levels of the selected biofilm resistance genes (ndvB, tssC1, PA5033 and PA2070) in the biofilm structure compared to planktonic cells.
View Article and Find Full Text PDFStructural, biocompatibility, and antibacterial properties of Ge-DLC nanocomposite for biomedical applications.
J Biomed Mater Res B Appl Biomater
July 2022
Molecular Biology and Genetics Department, Faculty of Science, Erzurum Technical University, Erzurum, Turkey.
Integrative production of new nanocomposites has been used to enhance favorable features of biomaterials for unlocking ultimate potential of different molecules. In the present study, advantageous properties of diamond like carbons (DLC) and germanium (Ge) like greater biocompatibility and antibacterial attributes were aimed to combined into a thin film. For this purpose, 400 nm DLC-Ge nanocomposite was coated on the borosilicate glasses via the magnetron sputtering and surface characteristics was analyzed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and The Raman spectrum.
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