6 results match your criteria: "High Education Mega Center[Affiliation]"

A novel simple traumatic brain injury mouse model.

Chin Neurosurg J

April 2022

School of Medicine, Sun Yat-Sen University, 132# Waihuandong Road, High Education Mega Center, Guangzhou, 510006, P. R. China.

Background: Traumatic brain injury, one of the leading causes of death in adults under 40 years of age in the world, is frequently caused by mechanical shock, resulting in diffuse neuronal damage and long-term cognitive dysfunction. Many existing TBI animal models revival with expensive equipment or special room are needed or the processes of operations are complex and not easy to be widely used. Therefore, a simpler TBI model needs to be designed.

View Article and Find Full Text PDF

Background: Inflammatory bowel disease (IBD) includes ulcerative colitis (UC) and Crohn's disease (CD), which is a common idiopathic digestive disease without a specific cure or treatment for improvement. Because Polygoni multiflori Radix has a traditional medicinal use to treat intestinal diseases, and the water extract of this herbal medicine had a positive influence on dextran sulfate sodium (DSS) induced UC model in our study. Meanwhile 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (TSG) as the major component of the water extract of Polygoni multiflori Radix with yield of more than 10% exhibited the remarkable anti-inflammatory activity in vivo and in vitro, we predicted that TSG may contribute to benefit intestinal tract presented by the water extract of Polygoni multiflori Radix.

View Article and Find Full Text PDF

Combination of Phospholipid Complex and Submicron Emulsion Techniques for Improving Oral Bioavailability and Therapeutic Efficacy of Water-Insoluble Drug.

Mol Pharm

March 2018

Department of Pharmaceutics, School of Pharmacy , Guangdong Pharmaceutical University , No. 280, Waihuandong Road , High Education Mega Center, Guangzhou 510006 , P. R. China.

Water-insoluble drugs cannot be absorbed effectively through the gastrointestinal tract due to insufficient solubility and often face the problems of low bioavailability and poor therapeutic efficacy. To overcome these biopharmaceutical challenges, lipid-based formulations were suggested and have been researched in recent years. In this study, we used atorvastatin as a model drug to prepare a phospholipid complex prodrug system to upgrade its lipophilicity and further developed a drug loaded submicron emulsion to improve its in vivo bioavailability.

View Article and Find Full Text PDF

The assessment of the chronic hepatotoxicity induced by Polygoni Multiflori Radix in rats: A pilot study by using untargeted metabolomics method.

J Ethnopharmacol

May 2017

School of Chinese Material Medical of Guangzhou University of Chinese Medicine, 232 East Waihuan Rd, High Education Mega Center, Panyu District, Guangzhou, Guangdong Province 510006, PR China. Electronic address:

Unlabelled: Polygoni Multiflori Radix is the dried root of Polygonum multiflorum Thunb officially recorded in the Chinese Pharmacopoeia as HeShouWu (HSW) in Chinese pinyin. The processed HSW are commonly used in TCM to treat liver disease and Chinese Pharmacopoeia has described the actions of it to tonify liver-kidney, replenish essence and blood, blacken beard and hair, strengthen sinew and bone, and resolve turbidity and lower lipid hence making it use not only as a herbal medicine in TCM but also as supplementary food in health care.

Aim Of The Study: Concerns about the hepatotoxicity in association with Polygoni Multiflori Radix and its processed products have been reported in some countries.

View Article and Find Full Text PDF

Development of an optimized protocol for primary culture of smooth muscle cells from rat thoracic aortas.

Cytotechnology

November 2009

Department of Pharmacology and Toxicology, School of Pharmaceutical Sciences, Sun Yat-Sen University, East of Waihuan Road 132, High Education Mega Center, 510006, Guangzhou, People's Republic of China.

Primary culture of smooth muscle cells has been widely used as a valuable tool to study the molecular mechanisms underlying atherosclerosis and restenosis. Currently, tissue explants and enzymatic digestion methods are frequently applied to produce smooth muscle cells. Explants method is time consuming, usually taking several weeks.

View Article and Find Full Text PDF

[Bioavailability of As, Cu and Zn in two soils as affected by application of chicken manure and pig manure].

Huan Jing Ke Xue

September 2008

College of Environmental Science and Engineering, South China University of Technology, Guangzhou High Education Mega Center, Guangzhou 510006, China.

Animal manures contain higher As, Cu and Zn since organoarsenicals, copper and zinc additives are widely used in modern intensive animal production. A pot experiment in water spinach was conducted to investigate As, Cu and Zn bioavailability in a paddy soil (PS) and a lateritic red soil (LRS) applied with 2% and 4% (mass fraction) chicken manure (CM) and pig manure (PM), respectively. Soils without any fertilizer were included as the checks (CK).

View Article and Find Full Text PDF