The role of iNOS inhibition in the mechanism of the cardioprotective effect of new GABA and glutamic acid derivatives in the model of acute alcoholic myocardial injury in rats.

The cardioprotective effects of new derivatives of glutamic acid (glufimet) and GABA (mefargin) were studied in rats exposed to acute alcohol intoxication (AAI) under conditions of selective blockade of inducible NO-synthase (iNOS). AAI induced a pronounced decrease in the contractile function of the myocardium during exercise tests (load by volume, test for adrenoreactivity, isometric exercise), caused mitochondrial dysfunction and increased processes of lipid peroxidation (LPO) in heart cells. A decrease in NO production during iNOS inhibition and AAI improved the respiratory function of mitochondria, a decreased the level of LPO products, and increased mitochondrial superoxide dismutase activity of heart cells.

Endosperm Development Traits in a Comparative Analysis of Endospermogenesis and Embryogenesis in Angiosperms.

The article discusses the fertilization process, the nucleus position in the primary cell, specifics of early endosperm development, and the principles of its classification. A new, refined classification was proposed for endosperm development modes to include three hierarchic levels: types, subtypes, and variations. Two types were distinguished by the morphogenetic potentials of the micropylar and chalazal primary cells: cellular (karyokinesis is completed with cytokinesis in both cells) and helobial (only karyokinesis takes place in both cells, and the chalazal cell sometimes remains mononucleate).

Anther Wall Formation in Aeonium balsamiferum and A. ciliatum (Crassulaceae).

Similarities (features of the family Crassulaceae) and differences in anther development and structure were observed between Aeonium balsamiferum and A. ciliatum. Microsporangia are rounded in A.

[Accelerated aging as a risk of the education digitalization: possibilities for prevention.].

The work is devoted to the analysis of the education digitalization negative effects and the possibilities of their prevention consideration. The urgency of this problem in the modern conditions of combating the pandemic of the new coronavirus infection and moving a significant part of education and leisure to the virtual space is noted. Against the background of a deficit in physical activity and an increase in the information consumption duration, the participants in the experiment showed a significant increase in the frequency of mental and physical maladjustment symptoms occurrence, a decrease in performance indicators and a deterioration in the biological age parameters.

[Social interactions in long-term care.].

Modern society is becoming more and more complex, not only technologies are changing, but also its socio-age structure. For the first time, mankind found itself in a situation where there are more elderly people than young people, and it turned out to be not ready for this. A new task arises - the coordination of interactions and interests of many subjects of social interaction in the interests of the elderly.

[Working ability of elderly university teachers under the combined influence of breathing exercises and peptide bioregulator «Cortexin».].

The two-week use of special breathing exercises in combination with the Cortexin peptide bioregulator optimizes the functional state and increases the professional performance of older teachers more effectively compared to the single use of a pharmacological preparation. The maximum effect is noted immediately after the end of the course use of special breathing exercises and the peptide bioregulator and lasts for two months. The results obtained open up prospects for the use of breathing exercises to enhance and prolong the nootropic drugs and antihypoxants antistress and geroprotective effects.

[Obstructive sleep apnea syndrome and cognitive impairment].

Sleep-disordered breathing is associated with sleep fragmentation and reduced blood oxygenation due to apnea and hypopnea episodes. Multiple studies indicate that obstructive sleep apnea syndrome (OSAS) can have negative impact on cognitive functioning, primarily executive functions, attention, and episodic memory. The attention is also focused on cognition in patients with neurologic and psychiatric comorbidities.

Evaluation of Individual Risk Factors of Alcohol Preference in Rats.

We evaluated individual risk factors of the development of alcohol preference in a model of voluntary alcohol consumption. Drinking behavior was estimated in the two-bottle test, and other behavioral features were studied in the open field test, test for social interaction, and marble burying test. The low adaptive capacity of an animal, which was manifested in a shorter time spent in the center of the open field, and low consumption of ethanol when the animal first tasted it were the leading factors of the subsequent preference of alcohol under the conditions of free choice.

[The influence of self-massage combined with drug Noopept on the professional performance of teachers older.].

It is shown that the two-week use of self-massage of the head and neck in combination with the pharmacological drug Noopept improves the functional state and increases the professional performance of elderly teachers compared to single use of nootropic drug. The greatest increase in the functional state and professional performance was noted immediately after the course of self-massage of the head and neck in combination with the pharmacological drug Noopept. The combined effect of self-massage and nootropic drug on the functional state and professional performance indicators are maintained for 1-2 months, and by the end of the third month they are approaching the initial values.

[Post-graduated education and medical pedagogics: a new approach based on the competence-oriented educational program for neurologists in the field of children epileptology].

The highly qualified performance of jobs according to professional standards due to the reformed system of additional professional education is one of the objectives of practical health care. The development of the educational program 'Children epileptology. Clinical, diagnostic and treatment issues' for increasing the qualification of neurologists was based on the competent approach that orients the content and process of education on the formation of competence in work performance.