8,013 results match your criteria: "Herpes B"

Purpose: To report a case of exudative retinal detachment (ERD) in a child with Acute retinal necrosis (ARN).

Method: Retrospective Chart Review.

Result: A six-year-old boy presented with anterior uveitis with hypopyon and exudative retinal detachment with peripheral confluent patches of retinitis in the left eye.

View Article and Find Full Text PDF

Background: Maternal infections caused by the ToRCH complex, comprising Toxoplasma gondii (T.gondii), Rubella Virus (RV), Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV), are significant contributors to Bad Obstetric History (BOH). These infections can vertically transmit through the placental barrier, leading to complications in fetal development.

View Article and Find Full Text PDF

Background: Richter's transformation (RT) in chronic lymphocytic leukemia (CLL) is associated with poor prognosis and requires prompt modifications in patient care. CLL patients are susceptible to severe infections due to immune dysregulation induced by their malignancy and immunosuppressive therapies.

Case Presentation: We present a case of a 63-year-old man with CLL who previously achieved remission and presented with a right inguinal mass.

View Article and Find Full Text PDF

Herpes simplex virus type 1 (HSV-1) is the leading pathogen in the maxillo-facial region, affecting millions of individuals worldwide. Its periodic reactivation aligns with the most common course pattern of periodontal disease. The present study used RNA sequencing to investigate the transcriptomes of human gingival fibroblasts (HGFs) following HSV-1 infection from the early to late stages (12-72 h).

View Article and Find Full Text PDF

Infections with Cytomegalovirus (CMV), Herpes simplex virus 1 (HSV1) and Toxoplasma gondii (TG) have been implicated in severe mental illness. All three pathogens have high seroprevalence in the human population, are neurotropic and establish a persistent infection. We hypothesized that exposed (seropositive) patients with severe mental illness would show higher immunoglobulin G (IgG) concentrations than exposed healthy controls (HC).

View Article and Find Full Text PDF

Efficacy of Higher-Voltage Long-Duration Pulsed Radiofrequency for Spinal Zoster-Associated Pain: A Randomized Controlled Trial.

Pain Physician

December 2024

Department of Pain Management, West China Hospital/West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan Province, China.

Background: High-voltage (65 V) long-duration pulsed radiofrequency (HL-PRF) is an effective method for managing zoster-associated pain (ZAP), though the limited efficacy of and high recurrence rates associated with the procedure present concerns.

Objectives: This study aimed to investigate the safety and effectiveness of a higher-voltage HL-PRF treatment based on the original procedure for ZAP in the spinal area.

Study Design: A prospective, randomized, controlled trial.

View Article and Find Full Text PDF

Viral infections leading to inflammation have been implicated in several common diseases, such as Alzheimer's disease (AD) and type 1 diabetes (T1D). Of note, herpes simplex virus 1 (HSV-1) has been reported to be associated with AD. We sought to identify the transcriptomic changes due to HSV-1 infection and anti-viral drug (acyclovir, ACV) treatment of HSV-1 infection in dissociated cells from human cerebral organoids (dcOrgs) versus stem cell-derived pancreatic islets (sc-islets) to gain potential biological insights into the relevance of HSV-1-induced inflammation in AD and T1D.

View Article and Find Full Text PDF

This study aimed to investigate the efficacy and safety of fire needle plus cupping (FC) combined with oral famciclovir and gabapentin for the treatment of acute-phase herpes zoster (AHZ). This study was conducted as a superiority, randomized controlled trial in which 84 patients with AHZ who met the diagnostic criteria were selected and randomly assigned to three groups on a 1:1 basis. Group A: received oral famciclovir with gabapentin treatment (FG); Group B: received fire needle plus cupping (FC) with FG.

View Article and Find Full Text PDF

Evidence of "Silent" Hepatitis B Virus Infection in Psoriasis, Vitiligo, and Cases: A Pilot Study.

Indian J Dermatol

October 2024

From the Division of Biological Sciences, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India.

Article Synopsis
View Article and Find Full Text PDF

Viruses pose a significant challenge and threat to human health, as demonstrated by the current COVID-19 pandemic. Neurodegeneration, particularly in the case of Alzheimer's disease (AD), is significantly influenced by viral infections. AD is a neurodegenerative disease that affects people of all ages and poses a significant threat to millions of individuals worldwide.

View Article and Find Full Text PDF

Late complications and long-term care of adult CAR T-cell patients.

Hematology Am Soc Hematol Educ Program

December 2024

The David and Etta Jonas Center for Cellular Therapy, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL.

Article Synopsis
  • * Late complications include issues like cytopenias, infections, secondary cancers, and delayed neurotoxicities, often requiring careful monitoring and supportive treatments.
  • * It is crucial for healthcare providers to work together to manage these late effects, ensuring patients receive proper follow-up care to improve their quality of life and outcomes post-treatment.
View Article and Find Full Text PDF

Apoptosis, MAPK signaling pathway affected in tilapia liver following nano-microplastics and sulfamethoxazole acute co-exposure.

Comp Biochem Physiol Part D Genomics Proteomics

March 2025

Wuxi Fishery College, Nanjing Agricultural University, Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture and Rural Affairs, Freshwater Fisheries Research Center (FFRC), Chinese Academy of Fishery Sciences (CAFS), Wuxi, Jiangsu 214081, China; College of Fisheries, Tianjin Agricultural University, Wuxi, Jiangsu 214081, China. Electronic address:

Studies showed that toxicants that adhered to the surface of nano-microplastics (NPs) have toxicological effects. Juvenile tilapia were divided into four groups namely the control group (A), 100 ng·L sulfamethoxazole (SMZ) group (B), 75 nm NPs group (C) and SMZ + 75 nm NPs group (D), and were exposed to an acute test for 2, 4 and 8 days. The hepatic histopathological changes, enzymatic activities, transcriptomics and proteomics analysis have been performed.

View Article and Find Full Text PDF

Herpes simplex virus (HSV) encodes surface glycoproteins that are host defense evasion molecules, allowing the virus to escape immune clearance. In addition to their role in neuropathogenesis and cell-cell spread, glycoproteins E and I (gE/gI) form a viral Fc receptor (vFcR) for most subclasses and allotypes of human IgG and promote evasion of humoral immune responses. While monoclonal antibodies (mAbs) protect mice from neonatal HSV (nHSV) infections, the impact of the vFcR on mAb-mediated protection by binding to IgG is unknown.

View Article and Find Full Text PDF

Broad Analysis of Serum and Intrathecal Antimicrobial Antibodies in Multiple Sclerosis Underscores Unique Role of Epstein-Barr Virus.

Neurol Neuroimmunol Neuroinflamm

January 2025

From the Department of Neurology (F.P., C.O., P.S., M.N., K.R.), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin; Institute for Experimental Immunology (D.W., T.L., K.S., E.G.-G.), affiliated with EUROIMMUN Medizinische Labordiagnostika AG, Luebeck; and Molecular Neuroimmunology Group (B.W., S.J.), Department of Neurology, University of Heidelberg, Germany.

Article Synopsis
  • - The study investigates the relationship between the Epstein-Barr virus (EBV) and multiple sclerosis (MS) by analyzing the presence of antibodies against EBV and other common microbes in patients with MS, revealing a universal EBV seroprevalence among participants.
  • - A total of 50 MS patients were tested for antibodies in their cerebrospinal fluid (CSF) and serum, finding that while all patients were EBV positive, the production of specific antibodies in the CSF was significantly lower for EBV compared to other viruses like measles and VZV.
  • - The results indicate that even though almost all MS patients have been exposed to EBV, the actual production of antibodies against EBV in the central
View Article and Find Full Text PDF
Article Synopsis
  • Coronary artery disease (CAD) and major depressive disorder (MDD) are interconnected cardiovascular conditions, but their shared mechanisms and treatment strategies are not fully understood.
  • Research utilized functional enrichment analyses and protein interaction networks to find hub genes and assess immune cell involvement in CAD and MDD.
  • Key overlapping genes (CDC42, NDUFB3, TXN) were identified, along with the drug candidate GS-9620, suggesting potential for dual-target treatment for both CAD and MDD.
View Article and Find Full Text PDF

Introduction: The Inflation Reduction Act (IRA) eliminated cost sharing for Medicare Part D-covered vaccines but did not address the cost burden faced by Medicare beneficiaries who did not have prescription drug coverage. This study aimed to determine the characteristics of beneficiaries without prescription drug coverage and to assess the association between the receipt of a herpes zoster vaccine and prescription drug coverage status.

Methods: We used the 2019-2023 National Health Interview Survey and included Medicare beneficiaries aged 65 years and older who enrolled in both Parts A and B or a Medicare Advantage plan.

View Article and Find Full Text PDF

We studied a family with three male individuals across two generations affected by common variable immune deficiency (CVID). We identified a novel missense heterozygous variant (c.2602T>A:p.

View Article and Find Full Text PDF

Cryptic phosphoribosylase activity of NAMPT restricts the virion incorporation of viral proteins.

Nat Metab

December 2024

Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

As obligate intracellular pathogens, viruses activate host metabolic enzymes to supply intermediates that support progeny production. Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme of salvage nicotinamide adenine dinucleotide (NAD) synthesis, is an interferon-inducible protein that inhibits the replication of several RNA and DNA viruses through unknown mechanisms. Here, we show that NAMPT restricts herpes simplex virus type 1 (HSV-1) replication by impeding the virion incorporation of viral proteins owing to its phosphoribosyl-hydrolase (phosphoribosylase) activity, which is independent of the role of NAMPT in NAD synthesis.

View Article and Find Full Text PDF

Background: There may be potential associations between various pathogens, antibody immune responses, and breast cancer (BC), but the specific mechanisms and causal relationships remain unclear.

Methods: First, multiple Mendelian randomization (MR) methods were used for univariable MR analysis to explore potential causal relationships between 34 antibody immune responses (related to 12 pathogens), 46 antibody immune responses (related to 13 pathogens), antibody responses post-COVID-19 vaccination, 731 immune cell types, and various BC subtypes (including overall BC, ER-positive, ER-negative, Luminal A, Luminal B, Luminal B HER2-negative, HER2-positive, and triple-negative BC). The primary results were then subjected to reverse MR analysis, heterogeneity testing using Cochran's Q, and horizontal pleiotropy testing.

View Article and Find Full Text PDF
Article Synopsis
  • JAK inhibitors, used to treat rheumatoid arthritis, can increase the risk of herpes zoster, prompting the need for appropriate vaccination timing with the recombinant zoster vaccine (RZV).
  • The STOP HZ study aims to determine whether initiating tofacitinib at the first or second RZV vaccination affects patients' immune response (IgG titers and T cell response) and disease activity.
  • This multicenter, randomized study will recruit 60 patients and measure various treatment outcomes, all while conforming to ethical guidelines and requiring informed consent.
View Article and Find Full Text PDF