4 results match your criteria: "Hepatology and Nutrition of Cincinnati Children's Hospital Medical Center[Affiliation]"

Article Synopsis
  • - The 2020 Nobel Prize in Medicine was awarded to Drs. Harvey Alter, Michael Houghton, and Charles Rice for their groundbreaking work on the hepatitis C virus, leading to lifesaving therapies.
  • - The tribute discusses the historical significance of the laureates' discoveries and includes insights from a forum held by the American Association for the Study of Liver Diseases, where the laureates shared advice for emerging scientists.
  • - Colleagues and peers in the research community also contribute personal reflections and stories about their experiences working with the Nobel laureates.
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Article Synopsis
  • The study investigates factors that impact outcomes in patients with biliary atresia, focusing on gene expression and clinical data to identify markers for survival without liver transplantation.
  • A total of 171 liver biopsies were analyzed to find a gene expression pattern of 14 specific mRNAs linked to varying survival times, showing significant predictive value related to transplant-free survival at 24 months.
  • Additionally, the research involved using mouse models and antioxidant treatments to explore underlying biological mechanisms, finding that certain gene expressions correlated with complications like cirrhosis, further affecting survival outcomes.
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Unlabelled: Peribiliary glands (PBGs) are clusters of epithelial cells residing in the submucosal compartment of extrahepatic bile ducts (EHBDs). Though their function is largely undefined, they may represent a stem cell niche. Here, we hypothesized that PBGs are populated by mature and undifferentiated cells capable of proliferation in pathological states.

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Article Synopsis
  • Young age at portoenterostomy may improve outcomes for biliary atresia, but biological factors can affect disease progression; this study investigates if molecular profiling of the liver can reveal disease stages at diagnosis.
  • Researchers analyzed liver biopsies from 47 infants, scoring inflammation and fibrosis, and found a unique molecular signature in 14 livers, allowing classification of the remaining biopsies.
  • The study highlights that the inflammation signature is linked to younger age at diagnosis, while the fibrosis signature correlates with lower chances of survival without transplant, suggesting that molecular profiling can inform disease staging and clinical outcomes.
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