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The Spectrum of Reflux Phenotypes.
Gastroenterol Hepatol (N Y)
December 2019
Dr Mahoney is an instructor in pediatrics and Dr Rosen is an associate professor of pediatrics at Harvard Medical School in Boston, Massachusetts, as well as in the Motility and Functional Gastrointestinal Disorders Center and the Division of Gastroenterology, Hepatology and Nutrition at Boston Children's Hospital in Boston, Massachusetts.
The focus on a symptom-based definition for gastroesophageal reflux disease (GERD) in adults and children has contributed to widespread use of acid suppression medications in patients with so-called typical reflux symptoms to treat the possibility of acid-mediated disease. Diagnostic testing with upper endoscopy, esophageal biopsies, ambulatory reflux monitoring, and/or esophageal manometry is often pursued when patients do not respond optimally to these medications. By using information from this diagnostic testing, GERD has shifted from a single diagnosis to a phenotypic spectrum, and each phenotype has unique pathophysiologic mechanisms driving symptom perception.
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