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Insulin resistance in non-diabetic patients with chronic hepatitis C: what does it mean?

Arq Bras Endocrinol Metabol

August 2011

Hepatology Reference Center, Gastroenterology Department, Universidade Federal de Juiz de Fora, Rua Albino Martins Ribeiro 324, Juiz de Fora, Minas Gerais, Brazil.

Objectives: To determine the prevalence of insulin resistance (IR) in non-diabetic patients with chronic hepatitis C, and to assess the association between IR, laboratory parameters and histological findings.

Subjects And Methods: Eighty-two patients had their serum analyzed for glucose, lipid profile, C-reactive protein (CRP), ferritin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), HOMA-IR, viral load and HCV genotype. Patients with HOMA-IR levels > 2.

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