Researchers found that the Fibrosis-3 (FIB-3) index can accurately predict liver fibrosis progression in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), regardless of age.
In a study of 1,398 patients, the FIB-3 index performed as well as the Fibrosis-4 (FIB-4) index for those under 60, but outperformed it for patients aged 60 and older.
The FIB-3 index’s effectiveness suggests it could be a more reliable tool for assessing liver fibrosis than existing methods, enhancing diagnosis across different age groups.
Researchers re-evaluated the modified NAFIC scoring system for diagnosing non-alcoholic steatohepatitis (NASH) in Japanese patients with non-alcoholic fatty liver disease (NAFLD), emphasizing the role of hyperinsulinemia.
The study involved 147 NAFLD patients for initial scoring and an additional 355 patients for validation, assessing factors like fasting serum insulin levels and serum ferritin.
Results indicated that the modified NAFIC score improved sensitivity and predictive value for NASH diagnosis, suggesting its potential as a useful clinical screening tool.