2,156 results match your criteria: "Hepato-Pancreato-Biliary Centre for Surgery & Transplantation[Affiliation]"
Clinical and Financial Validation of the International Study Group for Pancreatic Surgery (ISGPS) Definition of Post-Pancreatectomy Acute Pancreatitis (PPAP): International Multicenter Prospective Study.
Ann Surg
October 2024
Hepatopancreatobiliary and Liver Transplant Surgery, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Padua, Italy.
Objective: To validate the ISGPS definition and grading system of PPAP after pancreatoduodenectomy (PD).
Summary Background Data: In 2022, the International Study Group for Pancreatic Surgery (ISGPS) defined post-pancreatectomy acute pancreatitis (PPAP) and recommended a prospective validation of its diagnostic criteria and grading system.
Methods: This was a prospective, international, multicenter study including patients undergoing PD at 17 referral pancreatic centers across Europe, Asia, Oceania, and the United States.
Nesidioblastosis in Pregnancy: Navigating the Diagnostic and Therapeutic Challenges of a Rare Condition.
Cureus
October 2024
General Surgery, Rambam Medical Center, Haifa, ISR.
Article Synopsis
- * Managing nesidioblastosis includes both medical and surgical options, but effective treatments are not well understood, and the situation is even more complicated for pregnant patients due to limited information available.
- * A case study of a 22-year-old pregnant woman experiencing severe hypoglycemia highlights the challenges in diagnosing and treating this condition, emphasizing the need for more research to improve clinical practices.
Integrative multi-omics analysis reveals the role of tumor-associated endothelial cells and their signature in prognosis of intrahepatic cholangiocarcinoma.
J Transl Med
October 2024
Medical School of Chinese People's Liberation Army (PLA), Beijing, China.
Article Synopsis
- - This study investigates how tumor-associated endothelial cells (TECs) interact with immune cells in the tumor microenvironment and their effect on the prognosis of intrahepatic cholangiocarcinoma (ICC) patients
- - Using single-cell RNA sequencing, researchers identified TEC signatures and scores, finding that higher TEC scores correlate with KRAS mutations and a skewed immune response, indicating a more inflamed yet immunosuppressive environment
- - The research suggests that the TEC score can serve as a reliable biomarker for predicting ICC patient outcomes and response to immunotherapy, while also highlighting the CXCL12/CXCR4 signaling pathway as a potential therapeutic target.
Vascular Resection for Pancreas Cancer - 10-year Experience from a Single High Volume-center.
Ann Surg
October 2024
Hepato-Pancreato-Biliary Surgical Oncology Service.
Article Synopsis
- A study assessed the outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) who underwent different types of pancreatic surgeries between 2011 and 2023, including non-vascular resection (NVR), venous resection (VR), and arterial resection (AR).
- Findings revealed that while initial disease stage did not impact median time to recurrence (TTR) or overall survival (OS), patients who had VR experienced significantly shorter TTR and OS compared to those with NVR and AR.
- The use of chemotherapy or chemoradiation was found to enhance both TTR and OS, while AR was linked to higher 90-day mortality rates, emphasizing the importance of careful patient selection for this procedure
Nano-encapsulation of drugs to target hepatic stellate cells: Toward precision treatments of liver fibrosis.
J Control Release
December 2024
Division of Gastroenterology, Department of Internal Medicine at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China. Electronic address:
Liver fibrosis is characterized by excessive extracellular matrix (ECM) deposition triggered by hepatic stellate cells (HSCs). As central players in fibrosis progression, HSCs are the most important therapeutic targets for antifibrotic therapy. However, owing to the limitations of systemic drug administration, there is still no suitable and effective clinical treatment.
View Article and Find Full Text PDFFailure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort.
Ann Surg Oncol
October 2024
Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands.
Background: Failure to rescue (FTR) is defined as the inability to prevent death after the development of a complication. FTR is a parameter in evaluating multidisciplinary postoperative complication management. The aim of this study was to evaluate FTR rates after major liver resection for perihilar cholangiocarcinoma (pCCA) and analyze factors associated with FTR.
View Article and Find Full Text PDFCharacterization of pathological features and immune microenvironment in hepatic tuberculosis and pulmonary tuberculosis.
Front Cell Infect Microbiol
October 2024
Faculty of Hepato-Pancreato-Biliary Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
Article Synopsis
- Hepatic tuberculosis (HTB) is a rare form of tuberculosis that mimics liver cancer, complicating diagnosis and prompting a focus on pathological features for accurate identification.
- An analysis of 32 HTB cases revealed that these lesions commonly occur as single masses in the right lobe of the liver, with unique features such as higher granuloma frequency compared to pulmonary tuberculosis (PTB).
- The study also found that while the immune environment around HTB lesions had elevated macrophage and foxp3 cell counts compared to PTB, there was no significant difference in drug resistance between the two types of tuberculosis.
Novel insights into the role of immunomodulatory extracellular vesicles in the pathogenesis of liver fibrosis.
Biomark Res
October 2024
Division of Gastroenterology, Department of Internal Medicine at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Article Synopsis
- Liver fibrosis is a serious condition that can progress to liver cancer and failure, and early detection and treatment remain difficult.
- The process involves liver inflammation and the activation of hepatic stellate cells, which are influenced by communication between various immune cells and the release of extracellular vesicles (EVs).
- EVs play a key role in the inflammatory response and offer promising diagnostic and therapeutic options for liver fibrosis due to their stability, compatibility, and low toxicity.
Refining the role of presurgical PET/4D-CT in a large series of patients with primary hyperparathyroidism undergoing [F]Fluorocholine PET/CT.
Eur J Clin Invest
February 2025
Nuclear Medicine, Institut de Cancérologie de Strasbourg Europe (ICANS), Strasbourg University Hospitals, University of Strasbourg, Strasbourg, France.
Article Synopsis
- A study evaluated the effectiveness of a diagnostic strategy combining [F]Fluorocholine PET/CT with 4D-CT for patients with primary hyperparathyroidism (pHPT) undergoing surgery.
- The results showed that PET/CT was significantly more accurate than 4D-CT, with high sensitivity and specificity rates (83% and 97%, respectively), whereas 4D-CT had lower rates (53% sensitivity).
- When PET/CT results were inconclusive, using the two imaging methods together improved diagnostic accuracy, making it a recommended personalized imaging approach for pHPT patients.
Current management of hepatobiliary malignancies between centers with or without a liver transplant program: A multi-society national survey.
Dig Liver Dis
February 2025
Department of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padova, Italy.
Article Synopsis
- This study looked at how different hospitals approach treating liver cancer, especially regarding liver transplants.
- They surveyed 75 hospital directors to see if those with liver transplant programs treat patients differently compared to those without.
- The results showed that hospitals with transplant programs were more likely to recommend transplants for certain types of liver cancer and other liver diseases than those without, showing a need for better communication between the two types of centers.
Small cyst size and lack of growth as negative predictors of malignant transformation in low-risk intraductal papillary mucinous neoplasms of the pancreas: A systematic review and meta-analysis.
United European Gastroenterol J
October 2024
Department of Gastroenterology & Hepatology, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Article Synopsis
- Current guidelines recommend monitoring small branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) that lack worrying features, as they have a low risk of becoming cancerous over time.
- A review of 21 studies indicated that smaller cyst sizes (≤15 mm) and stable growth patterns significantly lower the chances of developing concerning characteristics or malignancy.
- The findings suggest that stable cyst sizes are particularly reassuring, highlighting the need for consistent definitions in future research to improve surveillance protocols.
Machine learning model to predict early recurrence in patients with perihilar cholangiocarcinoma planned treatment with curative resection: a multicenter study.
J Gastrointest Surg
December 2024
Department of General Surgery, Youyang Hospital, A Branch of The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Article Synopsis
- The study focuses on developing a preoperative prediction model for early recurrence in patients with perihilar cholangiocarcinoma (pCCA) after surgery, as this is a major cause of death in these patients.
- It involved 400 pCCA patients who underwent curative resection, with data divided into training and testing groups to identify significant predictive variables using LASSO regression alongside various machine learning models.
- Among the findings, five key factors were identified, and the random forest model showed the highest predictive accuracy with a notable difference in recurrence-free survival rates between high-risk and low-risk patients.
Emergency pancreaticoduodenectomy for complex pancreaticoduodenal damage with multiple organ injuries following blunt abdominal trauma: A case report and literature review.
Int J Surg Case Rep
November 2024
Department of Abdominal Surgery, Military Hospital 175, Ho Chi Minh City 70000, Viet Nam.
Article Synopsis
- Pancreaticoduodenectomy, a complex surgery, risks complications like pancreatic fistula and bile leakage, with emergency cases posing even higher threats due to patients’ unstable conditions.
- A case of a 49-year-old man who suffered severe abdominal injuries from a truck collision illustrates the challenges; despite instability, he underwent emergency pancreaticoduodenectomy and additional surgeries, facing postoperative issues managed conservatively.
- Although high-risk, emergency pancreaticoduodenectomy can be lifesaving for trauma patients with severe injuries, it should only be performed by experienced surgeons at specialized centers.
Effect of Ultrasound-Guided External Oblique Intercostal Block on Postoperative Recovery After Subxiphoid Video-Assisted Thoracoscopic Thymectomy: A Randomized Controlled Trial.
J Ultrasound Med
January 2025
Department of Hepato-Pancreato-Biliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, China.
Objective: Severe postoperative pain can occur after subxiphoid video-assisted thoracoscopic thymectomy (SVATT), affecting the quality of postoperative recovery. This study aimed to evaluate the effect of ultrasound-guided external oblique intercostal (EOI) block on recovery after SVATT.
Methods: A total of 60 patients undergoing SVATT were randomly divided into the EOI group (group E, n = 30) and the control group (group C, n = 30).
Effectiveness, safety, and biomarker analysis of lenvatinib plus toripalimab as chemo-free therapy in advanced intrahepatic cholangiocarcinoma: a real-world study.
Cancer Immunol Immunother
October 2024
State Key Laboratory of Complex Severe and Rare Diseases, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, 100730, China.
Article Synopsis
- * A total of 78 patients were treated, showing a median overall survival of 11.3 months and progression-free survival of 5.4 months, with a 19.2% objective response rate.
- * Findings suggest that baseline CA19-9 levels and IDH1 mutations could predict treatment response, making lenvatinib plus toripalimab a promising option for managing advanced ICC.
Pancreatoduodenectomy after Ivor-Lewis Santi oesophagectomy with gastric tube reconstruction. An European multicentre experience.
Surg Oncol
December 2024
Department of Digestive, Oncological and Metabolic Surgery, Institut Mutualiste Montsouris, Paris, France.
Background: Pancreaticoduodenectomy (PD) is the standard surgery to treat tumors and other conditions affecting the head of the pancreas. PD involves the division of the gastroduodenal artery (GDA) and its branches, to allow for complete dissection of lymph nodes. However, PD in patients with prior esophageal resection presents challenges due to altered anatomy and risks compromising gastric tube vascularization.
View Article and Find Full Text PDFGPR56 facilitates hepatocellular carcinoma metastasis by promoting the TGF-β signaling pathway.
Cell Death Dis
October 2024
Hepatic Surgery Centre, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Wuhan, Hubei, 430030, China.
The metastasis of hepatocellular carcinoma (HCC) poses a significant threat to the survival of patients. G protein-coupled receptor 56 (GPR56) has garnered extensive attention within malignant tumor research and plays a crucial role in cellular surface signal transmission. Nonetheless, its precise function in HCC remains ambiguous.
View Article and Find Full Text PDFIs prolonged operative time associated with postoperative complications in liver surgery? An international multicentre cohort study of 5424 patients.
Surg Endosc
December 2024
Department of Surgery, Fondazione Poliambulanza Istituto Ospedaliero, Via Leonida Bissolati, 57, 25124, Brescia, Italy.
Article Synopsis
- The study investigates how the length of time taken during liver surgeries affects the likelihood of postoperative complications in patients undergoing different types of liver resections.
- A total of 5,424 patients were analyzed from multiple centers between 2000 and 2022, focusing on procedures like right hemihepatectomy, technically major resection, and left lateral sectionectomy.
- Results show that patients in the longest operative time group had a significantly higher risk of complications, particularly in various surgical approaches like open, laparoscopic, and robotic surgeries.
Use of indocyanine green-human serum albumin complexes in fluorescence image-guided laparoscopic anatomical liver resection: a case series study (with video).
Surg Endosc
November 2024
Liver Transplantation Center, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, 37 Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, China.
Background: This study aimed to investigate the feasibility and efficacy of near-infrared fluorescence-guided laparoscopic anatomical hepatectomy (LAH) using a novel indocyanine green (ICG)-human serum albumin complex (HSA) in patients with hepatocellular carcinoma.
Methods: Clinical data of hepatocellular carcinoma patients who underwent ICG-HSA fluorescence-guided LAH at our center from January 2024 to April 2024 were prospectively collected and analyzed. Ultraviolet absorption spectroscopy was used to test the absorption and stability of ICG-HSA complex solutions under different conditions.
Nurturing the next generation of HPB surgeons: short term results of the pilot E-AHPBA mentorship program.
HPB (Oxford)
December 2024
Amsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands; Cancer Center Amsterdam, The Netherlands.
Efficacy and safety of a preventive strategy against tuberculosis in liver transplantation recipients including the treatment of latent infection with moxifloxacin.
Transpl Infect Dis
December 2024
Unit of Infectious Diseases, University Hospital "12 de Octubre", Instituto de Investigación Hospital "12 de Octubre" (imas12), Madrid, Spain.
Background: Preventive management of tuberculosis in liver transplantation (LT) is challenging due to difficulties in detecting and treating latent tuberculosis infection (LTBI). The aim of this study was to analyze the safety and efficacy of a screening strategy for LTBI with the inclusion of moxifloxacin as treatment.
Methods: We performed a retrospective single-center study of all LTs performed between 2016 and 2019 with a minimum 4-year follow-up and a standardized protocol for the evaluation of LTBI.
Circulating Gut Microbe-Derived Metabolites Are Associated with Hepatocellular Carcinoma.
Biomedicines
August 2024
Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Unlabelled: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. The gut microbiome has been implicated in outcomes for HCC, and gut microbe-derived products may serve as potential non-invasive indices for early HCC detection. This study evaluated differences in plasma concentrations of gut microbiota-derived metabolites.
View Article and Find Full Text PDFActin like 6A is a prognostic biomarker and associated with immune cell infiltration in cancers.
Discov Oncol
September 2024
Hepatic Surgery Center, Clinical Medicine Research Centre for Hepatic Surgery of Hubei Province, and Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 Jie Fang Avenue, Wuhan, 430030, China.
Article Synopsis
- Scientists studied a gene called ACTL6A to see how it affects cancer and why it might be important.
- They found that this gene is often increased in many types of cancer, which could make things worse for patients.
- The research suggests that ACTL6A might also help immune cells enter tumors, which could be helpful for creating new ways to treat cancer.
Economic Evaluations of Robotic-Assisted Surgery: Methods, Challenges and Opportunities.
Appl Health Econ Health Policy
January 2025
Health Economics and Health Technology Assessment, School of Health and Wellbeing, University of Glasgow, Glasgow, UK.
Background: The use of robotic-assisted surgery (RAS) is growing rapidly. However, economic evaluation of this technology is challenging. This study aims to identify and discuss the different economic evaluation methods which have been used to evaluate RAS.
View Article and Find Full Text PDFRegulator of nonsense transcripts 3B is a prognostic biomarker and associated with immune cell infiltration in lung squamous cell and hepatocellular carcinoma.
Discov Oncol
September 2024
Hepatic Surgery Center, Clinical Medicine Research Centre for Hepatic Surgery of Hubei Province, and Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China.
Purpose: The characteristic of RENT3B in cancer remains ambiguous. We aimed to study the relationship between RENT3B and immune infiltration in liver hepatocellular carcinoma (LIHC) and lung squamous cell carcinoma (LUSC).
Patients And Methods: We investigated the expression levels of RENT3B using ONCOMINE and TIMER databases, and assessed the interrelationship between RENT3B expression and survival using PrognoScan, GEPIA, and Kaplan-Meier plotter.