A new potential therapeutic approach for ALS: A case report with NGS analysis.

Rationale: Amyotrophic lateral sclerosis (ALS) poses a significant clinical challenge due to its rapid progression and limited treatment options, often leading to deadly outcomes. Looking for effective therapeutic interventions is critical to improve patient outcomes in ALS.

Patient Concerns: The patient, a 75-year-old East Asian male, manifested an insidious onset of right-hand weakness advancing with dysarthria.

Machine learning-directed electrical impedance tomography to predict metabolically vulnerable plaques.

The characterization of atherosclerotic plaques to predict their vulnerability to rupture remains a diagnostic challenge. Despite existing imaging modalities, none have proven their abilities to identify metabolically active oxidized low-density lipoprotein (oxLDL), a marker of plaque vulnerability. To this end, we developed a machine learning-directed electrochemical impedance spectroscopy (EIS) platform to analyze oxLDL-rich plaques, with immunohistology serving as the ground truth.

ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK.

The compliance of the extracellular matrix (ECM) regulates osteogenic differentiation by modulating extracellular signal-regulated kinase (ERK) activity. However, the molecular mechanism linking ECM compliance to the ERK-mitogen-activated protein kinase (MAPK) pathway remains unclear. Furthermore, RhoA has been widely implicated in integrin-mediated signaling and mechanotransduction.

Treatment of dry weather urban runoff in tidal saltwater marshes: A longitudinal study of the Talbert Marsh in southern California.

The scientific literature presents conflicting assessments of whether tidal saltwater wetlands reduce or increase fecal indicator bacteria (FIB) impairment of marine bathing waters. In this paper we describe the use of a two end-member salinity-mixing model to calculate FIB treatment efficiencies for the Talbert Marsh, a tidal saltwater wetland in Orange County, California. The mixing model utilized FIB and salinity measurements (n = 10 716) collected during a three-year longitudinal study of the Talbert Marsh.

All-fiber acousto-optic polarization monitor.

We describe the operational principle of and experimentally demonstrate a narrowband, wavelength-tunable polarization monitor based on a fiber acousto-optic tunable filter. Two orthogonally vibrating acoustic waves are used to create a variable polarizer that can be used to measure the state of polarization of an incident narrowband light source. The accuracy of the polarization monitor is measured at two different wavelengths in reference to a commercial polarimeter and is shown to be within 5%.