2 results match your criteria: "Henry Ford Hospital and Henry Ford Health Sciences Center[Affiliation]"
Effect of GGC (glycine) repeat length polymorphism in the human androgen receptor on androgen action.
Prostate
February 2005
Vattikuti Urology Institute, Henry Ford Hospital and Henry Ford Health Sciences Center, One Ford Place, Detroit, MI 48202, USA.
Background: The human androgen receptor (AR) contains glutamine (CAG) and glycine (GGC) repeat length polymorphisms. Normal glutamine repeat length affects androgen action, but an effect of normal glycine repeat length has not been studied.
Methods: To determine whether glycine/GGC repeat length affects AR function, we constructed AR cDNA expression vectors with different GGC repeat lengths in the physiological range (13-17 GGCs).
Effect of a short CAG (glutamine) repeat on human androgen receptor function.
Prostate
January 2004
The Vattikuti Urology Institute, Henry Ford Hospital and Henry Ford Health Sciences Center, Detroit, Michigan 48202-3450, USA.
Background: The human androgen receptor (AR) gene contains an uninterrupted CAG repeat that is polymorphic in length in the general population (range, 11-31 CAG's; median, 21). The CAG repeat encodes a glutamine repeat in the N-terminal transactivation domain of the AR protein. We previously reported that a 17-CAG AR gene was much more common in a cohort of men with prostate cancer (8.
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