12 results match your criteria: "Henri Poincaré University Nancy[Affiliation]"

Purpose: In an update of the randomized, open-label, phase III European Mantle Cell Lymphoma (MCL) Elderly trial (ClinicalTrials.gov identifier: NCT00209209), published in 2012, we aimed to confirm results on long-term outcome focusing on efficacy and safety of long-term use of rituximab maintenance.

Patients And Methods: Five hundred sixty patients with newly diagnosed MCL underwent a first random assignment between rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) and rituximab, fludarabine, and cyclophosphamide (R-FC) induction, followed by a second random assignment in 316 responders between rituximab and interferon alfa maintenance, to be continued until progression.

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New mechanisms and targets for IBD Therapy: translational gastroenterology comes of age.

Curr Drug Targets

November 2013

Inserm U954 and Department of Gastroenterology, Nancy University Hospital, Henri Poincaré University Nancy 1, Allée du Morvan, 54 511 Vandoeuvre-lès-Nancy, France.

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Article Synopsis
  • Genomewide association studies link the FUT2 461G→A polymorphism to plasma vitamin B-12 levels and Helicobacter pylori infection susceptibility.
  • The study involved 1282 participants from Europe and West Africa, measuring vitamin B-12 and related metabolic markers while analyzing the relationship with the FUT2 polymorphism and H. pylori serology.
  • Results indicate that the FUT2 461 A/A genotype correlates with higher vitamin B-12 levels and that H. pylori presence does not affect these levels across different genotypes.
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Meta-analysis: hyperhomocysteinaemia in inflammatory bowel diseases.

Aliment Pharmacol Ther

November 2011

INSERM U954, Cellular and Molecular Pathology in Nutrition, Henri Poincaré University Nancy 1, and University Hospital of Nancy, Vandoeuvre-lès-Nancy, France.

Background: The magnitude of association between homocysteine metabolism and inflammatory bowel diseases (IBD) remains unknown, whereas the association between hyperhomocysteinaemia and thrombosis remains controversial in IBD.

Aim: To conduct a systematic review and meta-analysis to examine these issues.

Methods: The literature search was conducted using MEDLINE database and international conference abstracts from January 1966 to April 2011 and included all studies that evaluated plasma homocysteine level in IBD.

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Epilepsy is responsible for falls that are not systematically associated with seizures and that therefore suggest postural impairment. There are very few studies of postural control in patients with epilepsy and none of them focus on temporal lobe epilepsy (TLE), although part of the vestibular cortex is located in the temporal cortex. The aim of this study was to evaluate the characteristics of postural control in a homogeneous population of patients with complex partial TLE.

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The use of azathioprine in Crohn's disease during pregnancy and in the post-operative setting: a worldwide survey of experts.

Aliment Pharmacol Ther

March 2011

INSERM U954, Henri Poincaré University Nancy 1, University Hospital of Nancy, Allée du Morvan 54, Vandoeuvre-lès-Nancy, France.

Background: Although thiopurines are considered safe in humans, they are still pregnancy FDA category D drugs. Prevention of post-operative recurrence is a challenge in clinical practice in Crohn's disease. The European Crohn's and Colitis Organisation consensus states that thiopurines should be considered in high-risk patients.

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Manganese superoxide dismutase plays a role in breast tumor cell growth, which depends on its constitutive expression. However, the mechanisms responsible for the regulation of constitutive SOD2 gene expression at different malignant phenotype in breast cancers remain to be determined. The present study reports the identification and characterization of a DNA sequence located in the proximal promoter of the SOD2 gene, which forms a complex with a nuclear protein from breast tumor MCF-7 cells.

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Background: A poor postural stability in older people is associated with an increased risk of falling. The posturographic tool has widely been used to assess balance control; however, its value in predicting falls remains unclear.

Objective: The purpose of this prospective study was to determine the predictive value of posturography in the estimation of the risk of recurrent falls, including a comparison with standard clinical balance tests, in healthy non-institutionalized persons aged over 65.

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Developmental biology of urodele amphibians in microgravity conditions.

Adv Space Biol Med

December 2003

Laboratory of Experimental Biology-Immunology, EA 3442: Genetic, Signaling, Differentiation, Henri Poincaré University-Nancy 1, B.P. 239, 54506 Vandoeuvre-lès-Nancy, France.

Among the urodele amphibians, only Cynops pyrrhogaster and Pleurodeles waltl, two species of the Salamandridae family, were used in space experiments. The advantages for using urodeles reside (i) in reproduction: a few months after natural breeding, females can lay eggs in absence of males after a hormonal treatment, because spermatozoa were preserved in the cloacal pelvic glands of matted females, (ii) in the rate of development which is slower in Cynops and Pleurodeles than in the anuran Xenopus, (iii) in their physiological properties: they can live in a closed water container or in a moisturized environment, and they can fast during several days. Moreover, urodeles have an important phylogenetic interest.

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The effect of antihypertensive treatment on the development of large-artery remodeling in young animals has been widely studied, but reversal of established changes in older hypertensive animals has been largely ignored, although the latter represents a better paradigm for the human condition. We studied the effect of treatment with captopril plus hydrochlorothiazide, from 3 months onward, on geometry and wall stress of the thoracic aorta of adult (9 months, maturation) and old (15 months, senescence) spontaneously hypertensive rats; normotensive Wistar-Kyoto rats were used as controls. At 3 months of age, blood pressure, medial cross-sectional area, and internal diameter were higher in spontaneously hypertensive rats than in Wistar-Kyoto rats.

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Effect of boric acid solution on cartilage metabolism.

Biochem Biophys Res Commun

May 1997

Laboratory of Medical Biochemistry-School of Medicine, University Nancy I, Henri Poincare, Vandoeuvre, France.

Pelvic cartilage of chick embryo was used to demonstrate that presence of boron in culture medium decreases synthesis of proteoglycans, collagen and total proteins but on the other hand increases the release of these macromolecules. However, when glucose concentration in culture medium is brought to 22mM, the synthesis decrease is no longer observed, whereas release increase persists. Proteins released into the culture medium included heat shock proteins (70 hsp) and tumor necrosis factor alpha (TNF alpha).

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