2 results match your criteria: "Hengyang Medical School University of South China Hengyang Hunan China.[Affiliation]"
Exosomal circ_0032704 confers sorafenib resistance to hepatocellular carcinoma and contributes to cancer malignant progression by modulating the miR-514a-3p/PD-L1 pathway.
Ann Gastroenterol Surg
May 2024
Department of Pathology, the First Affiliated Hospital, Hengyang Medical School University of South China Hengyang Hunan China.
Article Synopsis
- The study investigates how circ_0032704 contributes to sorafenib resistance in hepatocellular carcinoma (HCC).
- The researchers utilized various assays to analyze the expression of circ_0032704, miR-514a-3p, and PD-L1, finding that circ_0032704 promotes resistance by regulating PD-L1 via miR-514a-3p.
- Inhibiting circ_0032704 reduced drug resistance and cancer cell proliferation, suggesting its potential as a biomarker in HCC diagnostics.
Disruption of disulfide homeostasis during biological processes can have fatal consequences. Excess disulfides induce cell death in a novel manner, termed as "disulfidptosis." However, the specific mechanism of disulfidptosis has not yet been elucidated.
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