Efficacy of comprehensive nursing in patients with pneumoconiosis and its influence on quality of life.

Objective: To investigate the efficacy of comprehensive nursing for patients with pneumoconiosis and its influence on patients' quality of life (QoL).

Methods: Sixty-two patients with pneumoconiosis diagnosed and treated in the Henan Provincial Institute for Occupational Health (Henan No. 3 Provicial People's Hospital) from October 2018 to October 2019 were included in this retrospective study.

Influence of Silica Exposure for Lung Silicosis Rat.

Objective: To investigate the influence of silica exposure on the expression of connective tissue growth factor (CTGF), transforming growth factor beta-1 (TGF-1), and platelet-derived growth factor (PDGF) in lung silicosis rat.

Methods: Wistar rats were divided into an experimental group and a control group. In the experimental group, rats were exposed to silica by intratracheal instillation.

[Effect of occupational stress on depression in gas field workers].

To explore the occurrence level of depressive symptoms and it's influencing factors among gas field workers. In October 2018, a cross-sectional study was conducted in 1726 gas field workers from a gas field by using cluster sampling method. Questionaire was used to evaluate the individual factors, depressive symptoms, occupational stress factors and stress regulatory factors.

[Correlation between social support and occupational stress among gas production workers in the field].

To investigate the level of social support and its correlation with occupational stress among gas production workers in the field. In October 2018, the cluster sampling method was used to perform a cross-sectional survey for 1726 gas production workers in the field, and related data of these workers were collected, including age, education level, marital status, level of social support, and related factors for occupational stress. A Spearman's rank correlation analysis was used to investigate the correlation between social support and occupational stress, and the levels of occupational stress-related factors were compared between the groups with different social support scores.

[Association between single nucleotides polymorphism of catalase gene and susceptibility to noise-induced hearing loss in occupational population].

Objective: To investigate the relationship between single nucleotides polymorphism of catalase(CAT) gene and susceptibility to noise-induced hearing loss(NIHL) in occupational noise exposed population.

Methods: A case-control study of 1∶1 was conducted to select 286 workers with binaural high frequency average hearing threshold ≥40 dB(HL), from 2006 to 2015 in a cohort study of occupational noise exposure workers in Henan Province. According to the type of work, the age difference was not more than 5 years and the length of exposure to noise was not more than 2 years.

[Analysis on the effect of sound insulation reconstruction in operation room of steel rolling production line in a steel plant].

To investigate the effect of sound insulation improvement on the noise exposure of workers in the operation room of hot rolling line for wide and heavy plate. From September 2019 to September 2017, based on the occupational health Survey, the data of 25 fixed operation rooms and workers in operation rooms of a steel rolling production line were collected retrospectively, the noise exposure levels before and after the improvement of sound insulation were statistically analyzed. The noise exposure value of the workers, the qualified rate of 0 Grade 8 hours equivalent noise (L(EX, 8 h)) ≤85 dB (A) and the qualified rate of the design limit value of the operation room were all higher than those before the modification, the difference was statistically significant (<0.

[Sleep quality and occupational stress relationship analysis of field gas recovery workers].

To explore the relationship between sleep quality and occupational stress in field gas recovery workers. In October 2018, cluster sampling method was adopted to conduct cross-sectional survey on 1726 field workers in a gas production oilfield. The individual characteristics, occupational stress factors, stress regulation factors, stress response and sleep quality, social support and coping strategies were evaluated by occupational stress measurement tools and job content questionnaire.

[Association between GSTP1 gave polymorphisms and susceptibility to noise-induced hearing loss].

To investigate the association between the single nucleotide polymorphisms (SNPS) at rs1695 and rs6591256 in glutathione S-transferase P1 (GSTP1) gene and susceptibility to noise-induced hearing loss in Chinese Han workers exposed to noise. A 1: 2 matched nested case-control study was performed, which based on the cohort of 6297 workers exposed to noise in an iron and steel plant in Henan, China, who were followed up from January 1, 2006 to December 31, 2015. According to the criteria of binaural average high-frequency hearing threshold ≥40 dB, a total of 292 workers were enrolled as hearing loss group; after the adjustment for sex, type of work, age (difference≤5 years) , and working years of noise exposure (difference≤2 years) , according to the criteria of binaural average high-frequency hearing threshold <35 dB, and the speech frequency hearing threshold of any ear at any frequency band ≤25 dB, a total of 584 workers were enrolled as control group.

[Prediction of KCNQ4gene polymorphism varies with CNE or noise exposure duration on the Risk of NIHL-Cox model analysis based on cohort study].

The purpose of this study was to explore the association between gene in the potassium recycling pathway 4 (KCNQ4) polymorphisms and the susceptibility to noise-induced hearing loss (NIHL) , and analysis the effect of cumulative noise exposure (CNE) and noise exposure duration on this association. A nested case-control study with 1∶1 matched was used based on the cohort of noise exposure in a steel factory. A total of 286 cases were selected as the group of hearing loss and 286 controls were chosen according to the matching standards of same gender, same type of work, age difference ≤ 5 years, noise exposure duration ≤ 2 years.

[Association between GSTP1 gene polymorphisms and susceptibility to noise-induced hearing loss].

To investigate the association between the single nucleotide polymorphisms (SNPS) at rs1695 and rs6591256 in glutathione S-transferase P1 (GSTP1) gene and susceptibility to noise-induced hearing loss in Chinese Han workers exposed to noise. Using the 1: 1 nested case-control study and taking 6297 workers exposed to noise in a steel plant in Henan province as the cohort study population in July 2019, we screened those who have been exposed to noise for ≥3 years and whose binaural high frequency (3000, 4000, 6000 Hz) average hearing threshold is ≥40 dB (A) into the case group. The control group was selected according to the matching criteria of the same sex, same type of work, and the age difference was not more than 5 years old, and the working age difference was not more than 2 years.

[Relationship research among CDH23 gene and the risk of noise-induced hearing loss].

To explore the relationship among CDH23 gene variation and the risk of noise-induced hearing loss (NIHL) . The nested case-control study was performed and this study followed a cohort of 6297 noise-exposed workers in a steel factory of Henan province in China from January 1, 2006 to December 31, 2015. In July 2019, subjects whose average hearing threshold were more than 40 dB in high frequency were defined as the case group, and subjects whose average hearing threshold were less than 35 dB in high frequency and less than 25 dB in speech frequency were defined as the control group.

[Relationship between depressive symptoms and occupational stress in locomotive drivers].

To explore relationship between depressive symptoms and occupational stress in locomotive drivers. By using cluster sampling method, a cross-sectional study was conducted in 1413 train drivers (including passenger train drivers301, freight train drivers 683, passenger shunting train drivers350, and high speed train drivers79) from a railway bureau. The individual factors, depression, occupational stress, strains, personalities, coping strategy and social support were measured using occupational stress instruments, job content questionnaire and effort-reward imbalance questionnaire.

[Change of occupational stress from 1996 to 2012 among train engine drivers].

To analyze the change of level of occupational stress between 1996 and 2012 among train engine drivers. the cross-section investigation was conducted by using cluster sampling method, subjects included 1 116 and 1 002 passenger train engine drivers and freight train engine drivers respectively in 1996 and in 2012;occupational stressors, strains, personalities, buffering factors and individual factors were investigated by using Occupational Stress Instruments. Unconditional logistic regression analyses were performed to estimate the associations between job stressors, personalities, buffering factors and individual factors and strains.

[Self-esteem and Occupational Stress Relationship Analysis of 1413 Train Drivers in a Railway Bureau].

To investigate self-esteem status of train drivers. By using cluster sampling method, a cross-sectional study was conducted in 1 413 train drivers (including passenger train drivers 301, freight train drivers683, passenger shunting train drivers350, and high speed train drivers79) from a railway bureau. The occupational stressors, strains, self-esteem and personalities were measured using occupational stress instruments and effort-reward imbalance questionnaire.

[Relationship between GRM7 gene polymorphisms and the susceptbility to noise-induced hearing loss].

Objective: To investigate the relationship between metabolic glutamate receptor 7 gene( GRM7) polymorphisms and the susceptibility to noise-induced hearing loss( NIHL) in Chinese Han occupational population.

Methods: Using a nested case-control study with a 1 ∶ 1 matching, a total of 277 cases of contacting noise workers were selected from a cohort in a steel factory. According to the matching criteria: the same sex, the same type of work, the age difference ≤ 5 years, contact noise length ≤ 2 years, 277 controls were selected.

Effect of GRM7 polymorphisms on the development of noise-induced hearing loss in Chinese Han workers: a nested case-control study.

Background: Noise-induced hearing loss (NIHL) is a complex, irreversible disease caused by the interaction of genetic and environmental factors. In recent years, a great many studies have been done to explore the NIHL susceptibility genes among humans. So far, high powerful detections have been founded that genes of potassium ion channel genes (KCNQ4 and KCNE1), catalase (CAT), protocadherin 15 (PCDH15), myosin 14 (MYH14) and heart shock protein (HSP70) which have been identified in more than one population may be associated with the susceptibility to NIHL.

[Sleep quality and occupational stress relationship analysis of 1413 train drivers in a railway bureau].

To investigate sleep quality status of train drivers. By using cluster sampling method, a cross-sectional study was conducted in 1413 train drivers (including passenger train drivers 301, freight train drivers 683, passenger shunting train drivers 350, and high speed train drivers 79) from a railway bureau. The occupational stressors, strains, personalities and sleep quality were measured using occupational stress instruments and effort-reward imbalance questionnaire.

The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population.

Noise-induced hearing loss (NIHL) is a complex disease caused by interactions between environmental and genetic factors. This study investigated whether genetic variability in protocadherin related 15 (PCDH15) underlies an increased susceptibility to the development of NIHL in a Chinese population. The results showed that compared with the TT genotype of rs11004085, CT/CC genotypes were associated with an increased risk of NIHL [adjusted odds ratio (OR) = 2.

[Influencing factors for job satisfaction in train drivers in a railway bureau: an analysis of 1413 cases].

To investigate the influencing factors for job satisfaction in train drivers. In March 2012, cluster sampling was used to conduct a cross-sectional survey in 1413 male train drivers (including 301 passenger train drivers, 683 freight train drivers, 350 passenger shunting train drivers, and 79 high-speed train drivers) from a locomotive depot of a railway bureau. The occupational stress instruments, job content questionnaire, and effort-reward imbalance questionnaire were used to analyze job satisfaction, occupational stress factors, stress reaction, individual characteristics, coping strategies, and social support.

[Association between serum magnesium ion level and risk of noise-induced hearing loss].

To investigate the association between serum magnesium ion level and risk of noise-induced hearing loss (NIHL) . Acohort study was performed for 7 445 workers exposed to noise in the steelmaking and steel rolling workshops of an iron and steel enterprise in Henan Province, China. The follow-up time was from January 1, 2006 to December 31, 2015.

[Social support and occupational stress relationship analysis of 1 413 train drivers in a railway bureau].

To investigate the social support status of train drivers. Using cluster sampling, a cross-sectional study was conducted in 1 413 male train drivers (including 301 passenger train drivers, 683 freight train drivers, 85 guest scheduling train drivers, 265 cargo adjustable drivers, and 79 high-speed train drivers) from a railway bureau depot. The survey included individual factors, social support, occupational stressors, strains, personalities, and coping strategy using occupational stress instruments and effort-reward imbalance questionnaire.

Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study.

Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. To explore the relationship between single nucleotide polymorphisms (SNPs) in heat shock protein 70 (HSP70) genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility to NIHL in Han Chinese workers exposed to noise, a case-control association study was carried out with 286 hearing loss cases and 286 matched with gender, age, type of work, and exposure time, drawn from a population of 3790 noise-exposed workers.

[Investigation into the relationship between mitochondrial 12 S rRNA gene, tRNA gene and cytochrome oxidase Ⅱ gene variations and the risk of noise-induced hearing loss].

To explore the relationship between mitochondrial 12 S rRNA gene variation, tRNA gene variation and cytochrome oxidase Ⅱ gene point mutations and the risk of noise-induced hearing loss (NIHL). A nested case-control study was performed that followed a cohort of 7 445 noise-exposed workers in a steel factory in Henan province, China, from January 1, 2006 to December 31, 2015. Subjects whose average hearing threshold was more than 40 dB(A) in high frequency were defined as the case group, and subjects whose average hearing threshold was less than 35 dB(A) in high frequency and less than 25 dB (A) in speech frequency were defined as the control group.

Effects of occupational exposure to carbon black on peripheral white blood cell counts and lymphocyte subsets.

The International Agency for Research on Cancer has classified carbon black (CB) as a possible (Group 2B) human carcinogen. Given that most CB manufacturing processes result in the emission of various types of chemicals, it is uncertain if the adverse health effects that have been observed in CB-exposed workers are related to CB specifically or are due to other exposures. To address this issue, we conducted a cross-sectional molecular epidemiology study in China of 106 male factory workers who were occupationally exposed to pure CB and 112 unexposed male workers frequency-matched by age and smoking status from the same geographic region.