Deciphering progressive lesion areas in breast cancer spatial transcriptomics via TGR-NMF.

Identifying spatial domains is critical for understanding breast cancer tissue heterogeneity and providing insights into tumor progression. However, dropout events introduces computational challenges and the lack of transparency in methods such as graph neural networks limits their interpretability. This study aimed to decipher disease progression-related spatial domains in breast cancer spatial transcriptomics by developing the three graph regularized non-negative matrix factorization (TGR-NMF).

In Situ Growth of Metal-Organic Layer on Polyoxometalate-etching Cu2O to Boost CO2 Reduction with High Stability.

Low-cost Cu2O with a suitable band gap holds great potential for solar utilization. However severe photocorrosion and weak CO2 capture capability have significantly hindered their application in artificial photosynthesis. Herein, polyoxometalate (POM)-etching and in situ growth of metal-organic framework (MOF) can simultaneously incorporate electron-sponge and HKUST protective layer into Cu2O.

Interpreting the Additive Components of Multi-Species Distributional Aggregation: II. Species-Level Insights.

The conspecific encounter index can be further decomposed into two components, which represent two ecological processes.

Symmetry Breaking of FeN4 Moiety via Edge Defects for Acidic Oxygen Reduction Reaction.

Fe-N-C catalysts, with a planar D4h symmetric FeN4 structure, show promising as noble metal-free oxygen reduction reaction catalysts. Nonetheless, the highly symmetric structure restricts the effective manipulation of its geometric and electronic structures, impeding further enhancements in oxygen reduction reaction performance. Here, a high proportion of asymmetric edge-carbon was successfully introduced into Fe-N-C catalysts through morphology engineering, enabling the precise modulation of the FeN4 active site.

Dirhodium-Palladium Dual-Catalyzed [1 + 1 + 3] Annulation to Heterocycles Using Primary Amines or HO as the Heteroatom Sources.

The ever-increasing demand in chemical biology and medicinal research requires the development of new synthetic methods for the rapid construction of libraries of heterocycles from simple raw materials. In this context, the utilization of primary amines or HO as the simple - or -sources in the assembly of a heterocyclic ring skeleton is highly desirable from the viewpoint of atom- and step-economy. Herein, we describe a highly efficient three-component reaction of diazo, allylic diacetates, and commercially available anilines (or HO) to access structurally diverse pyrrolidine and tetrahydrofuran derivatives.

Metal- and Light-Free Decarboxylative Giese Addition Reaction Facilitated by Hantzsch Ester.

We have developed a novel strategy for decarboxylative radical addition reactions that employs ground-state reduced nicotinamide adenine dinucleotide (NADH) analogues under ambient and open-air conditions, facilitating the efficient formation of Csp-Csp bonds in a variety of substrates. This protocol is distinguished by its operational simplicity, mild reaction conditions, high efficiency, and the use of cost-effective starting materials. Furthermore, experimental studies have provided valuable insights into the reaction mechanism, elucidating the light-independent pathways that promote these transformations.

Mix-Charged Nanofiltration Membrane for Efficient Organic Removal from High-Salinity Wastewater: The Role of Charge Spatial Distribution.

The efficient removal of organic contaminants from high-salinity wastewater is crucial for resource recovery and achieving zero discharge. Nanofiltration (NF) membranes are effective in separating organic compounds and monovalent salts, but they typically exhibit an excessive rejection of divalent salts. Modifying the charge characteristics of NF membranes can improve salt permeation; however, the role of charge spatial distribution in governing salt transport behavior is not fully understood.

Design, Synthesis, and Biological Evaluation of 1,3,4-Thiadiazole Derivatives as Novel Potent Peptide Deformylase Inhibitors for Combating Drug-Resistant Gram-Positive and -Negative Bacteria.

The prevalence of drug-resistant bacteria is a major challenge throughout the world, especially with respect to Gram-negative bacteria, such as drug-resistant , which are regarded as the greatest bacterial threat to human health by the World Health Organization (WHO). In this work, 1,3,4-thiadiazole was introduced into the main skeleton of the classical peptidomimetic peptide deformylase (PDF) inhibitor in pursuit of highly efficient and broad-spectrum bacteriostatic drugs. Upon detailed structure-activity relationship study, PDF inhibitors that possess satisfactory activity against both Gram-positive and Gram-negative bacteria as well as a lower potential for methemoglobin toxicity were screened out.

Team Perspective Taking and Collective Thriving in College Students' Innovation Teams.

Team perspective taking is a process of team member empathy, motivation for other people's ideas and feelings, and the ability to understand objectively. It can have positive impacts on teams, but the question of whether team perspective taking positively affects the sense of collective thriving exhibited by the team has not been answered, and the intrinsic mechanism underlying this influence has not been revealed. To explore the impact of team perspective taking on the collective thriving of college student innovation teams, this study constructs a chain mediation model based on theories such as the socially embedded model of thriving.

The Relationship Between School Organizational Climate and Teachers' Organizational Citizenship Behaviors: The Mediating Role of Teaching Efficacy and Moderating Role of Optimistic Traits.

This study examined the relationship between school organizational climate and teachers' organizational citizenship behavior, as well as the mediating role of teaching efficacy and the moderating role of optimistic traits. This study was based on social information processing theory, resource conservation theory, and the broaden-and-build theory of positive emotions. We conducted a comprehensive survey of 500 educators from Chinese primary and secondary schools using the Organizational Citizenship Behavior Questionnaire, School Organizational Climate Scale, Sense of Teaching Efficacy Scale, and Optimistic Traits Questionnaire as assessment tools.

Spontaneous Catalytic Reaction of a Surfactant in the Interfacial Microenvironment of Colloidal Gold Nanoparticles.

The performance of nanomaterials is significantly determined by the interfacial microenvironment, in which a surfactant plays an essential role as the adsorbent, but its involvement in the interfacial reaction is often overlooked. Here, it was discovered that citrate and ascorbic acid, the two primarily used surfactants for colloidal gold nanoparticles (Au NPs), can spontaneously undergo catalytic reaction with trace-level nitrogenous residue under ambient environment to form oxime, which is subsequently cleaved to generate CN or a compound containing the -CN group. Such a catalytic reaction shows wide universality in both reactants, including various carbonaceous and nitrogenous sources, and metal catalysts, including Au, Ag, Fe, Cu, Ni, Pt, and Pd NPs.

DjsoxP-1 and Djsox5 are essential for tissue homeostasis and regeneration in Dugesia japonica.

Sox genes encode a family of transcription factors that regulate multiple biological processes during metazoan development, including embryogenesis, tissue homeostasis, nervous system specification, and stem cell maintenance. The planarian Dugesia japonica contains a reservoir of stem cells that grow and divide continuously to support cellular turnover. However, whether SOX proteins retain these conserved functions in planarians remains to be determined.

Potential magnetic structure in Eu3InAs3 revealed by magnetization and thermodynamic study.

We systematically investigate the magnetization and thermodynamic responses associated with antiferromagnetic (AFM) transitions in single crystals of the magnetic semiconductor Eu3InAs3. The linear thermal expansion measurements around the AFM transition temperatures, TN1 and TN2, indicate an expansion along the a axis and contraction along the b and c axes. The calculated ∆V/V(T) shows a continuous change at TN, indicating a second-order magnetic phase transition.

Chemical O-ADP-Ribosylations: Synthesis and Bioconjugation of ADPr-Peptides/Proteins from NAD.

ADP-ribosylation is a complex post-translational modification involved in key physiological processes and associated with various health and disease states. The growing interest in ADP-ribosylation necessitates straightforward and efficient synthetic methods for the preparation of ADP-ribosylated peptides/proteins. In this study, we report a facile reaction between nicotinamide adenine dinucleotide (NAD+) and alcohols promoted by a combination of ionic liquids, yielding up to 94% with α:β ratios ranging from 88:12 to 99:1 and a switchable configuration selectivity.

N,O Co-Doped Carbon Spheres Enable Stable Anode-Less Sodium Metal Batteries.

Anode-less sodium metal batteries (SMBs) suffer from the formation of Na dendrites and inactive Na on an anode substrate though showing advantages of high energy densities and low costs. Herein, N,O co-doped carbon spheres (NOCS), which are synthesized via a scalable polymerization and pyrolysis method, are employed as a thin and stable sodiophillic nucleation layer on the Cu foil. Combined with electrochemical measurements, Na deposition morphology observations and density functional theory calculations, it is revealed that the introduced N and O heteroatoms can greatly enhance the adsorption of Na on the carbon substrate and reduce the nucleation overpotential, thus forming sufficient seeding sites and guiding homogeneous Na deposition.

Toxic effects and mechanistic insights of cadmium telluride quantum dots on the homeostasis and regeneration in planarians.

The widespread application of quantum dots (QDs) in recent years has raised concerns about potential environmental and human health risks. Although the toxicity of cadmium telluride quantum dots (CdTe QDs) has been partially studied, their effects on stem cells, tissue regeneration, neurodevelopment, and neurobehavioral toxicity remain unclear. This study aimed to investigate the combined toxic effects and mechanisms of CdTe QDs on planarians at the individual, tissue, cellular, and molecular levels.

Adsorption properties and mechanisms of Cd by co-pyrolysis composite material derived from peanut biochar and tailing waste.

Cadmium (Cd) contamination in aquatic systems is a widespread environmental issue. In this study, a solid waste iron tailings and biochar hybrid (Fe-TWBC) was successfully synthesized derived from co-pyrolysis of peanut shell and tailing waste (Fe-TW). Characterization analyses showed that the metal oxides from solid waste iron tailings successfully loaded onto the biochar surface, with more functional groups in Fe-TWBC.

Visible-light-induced aerobic oxidative cyclization of nitroarenes with triethylamine using an organophotocatalyst.

Isoxazolidines are structurally important scaffolds in many natural products and bioactive compounds. Herein, we report a novel synthetic method for isoxazolidine derivatives through visible-light-induced photoredox cascade cyclization of nitroarenes with triethylamine under aerobic conditions. The resultant 5-hydroxyl isoxazolidine compounds were generally obtained in moderate yields with a broad range of compatible functionalities.

R(3780) Resonance Interpreted as the 1^{3}D_{1}-Wave Dominant State of Charmonium from Precise Measurements of the Cross Section of e^{+}e^{-}→Hadrons.

We report the precise measurements of the cross section of e^{+}e^{-}→hadrons at center-of-mass energies from 3.645 to 3.871 GeV.

Unlocking Chiral Sulfinimidoyl Electrophiles: Asymmetric Synthesis of Sulfinamides Catalyzed by Anionic Stereogenic-at-Cobalt(III) Complexes.

Asymmetric catalysis involving a sulfoxide electrophile intermediate presents an efficient methodology for accessing stereogenic-at-sulfur compounds, such as sulfinate esters, sulfinamides, , which have garnered increasing attention in modern pharmaceutical sciences. However, as the aza-analog of sulfoxide electrophiles, the asymmetric issues about electrophilic sulfinimidoyl species remain largely unexplored and represent a significant challenge in sulfur stereochemistry. Herein, we exhibit an anionic stereogenic-at-cobalt(III) complex-catalyzed asymmetric synthesis of chiral sulfinamides via chiral sulfinimidoyl iodide intermediates.

Photoinduced Regiodivergent and Enantioselective Cross-Coupling of Glycine Derivatives with Hydrocarbon Feedstocks.

Regiodivergent asymmetric synthesis represents a transformative strategy for the efficient generation of structurally diverse chiral products from a single set of starting materials, significantly enriching their enantiomeric composition. However, the design of radical-mediated regiodivergent and enantioselective reactions that can accommodate a wide range of functional groups and substrates has posed significant challenges. The obstacles primarily lie in switching the regioselectivity and achieving high enantiodiscrimination, especially when dealing with high-energy intermediates.

A Borenium-Borane Composite for Exhaustive Reduction of Oxo-Chemicals.

Borenium ions have attracted significant attention in organic transformations due to their strong Lewis acidity. The reported borenium ions are often stabilized by sterically demanding substituents and strong coordination bonds. Herein, we have synthesized a small steric borenium-equivalent NHBHOTf and subjected it to the exhaustive reduction of a carboxylic functional group to a methyl group, which shows broad functional group tolerance.