The effects of an acute Tai Chi on emotional memory and prefrontal cortex activation: a fNIRS study.

Objective: Acute exercise has the potential to influence emotional memory and cortical hemodynamics, but the specific effects depend on the type of exercise. This study aimed to determine whether acute Tai Chi practice enhances emotional memory and prefrontal cortex activation compared to cycling and a control condition.

Methods: Using a within-subjects crossover design, 36 healthy university students completed three interventions: Tai Chi, cycling, and a resting control condition.

Amides Enable Room-Temperature CO Conversion: Simple Organic Molecules Challenging Metal Catalysts.

The conversion of carbon dioxide (CO) into valuable chemicals has been intensively pursued for sustainable chemistry. It is highly desirable to achieve the conversion under ambient conditions using organocatalysts instead of precious or pollutive metal catalysts. Herein, we disclose a new class of organocatalysts for direct C(sp)-H carboxylation with CO.

Identification and Application of the Heptad Repeat Domain in the CPR5 Protein for Enhancing Plant Immunity.

Plant resistance to pathogens can be significantly enhanced through genetic modification, thereby reducing the reliance on chemical pesticides. CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5 (CPR5) serves as a key negative regulator of plant immunity. Here we explored the functional domains of the CPR5 protein with the goal of dampening its activity to bolster plant immunity.

Identification of degradation risk areas and delineation of key ecological function areas in Qinling region.

As a critical component of the geographical divide between the northern and southern regions of China, the ecological stability of the Qinling region has profound implications for ecological balance within China and across East Asia. However, the degradation risk areas of the Qinling region remain unclear, and there are gaps in the delineation of key ecological protection areas. This study examines the improvement and decline in the Qinling region from 2000 to 2023 in terms of ecosystem patterns, quality, and functions.

The SnRK1-JMJ15-CRF6 module integrates energy and mitochondrial signaling to balance growth and the oxidative stress response in Arabidopsis.

Mitochondria support plant growth and adaptation via energy production and signaling pathways. However, how mitochondria control the transition between growth and stress response is largely unknown in plants. Using molecular approaches, we identified the histone H3K4me3 demethylase JMJ15 and the transcription factor CRF6 as targets of SnRK1 in Arabidopsis.

Associations of three diagnostic glycemic measures with all-cause and cardiovascular mortality in people not on antidiabetic medications: A prospective cohort study.

Objective: This study aimed to investigate the value of three diagnostic glycemic measures, i.e., 2-hour plasma glucose (2hPG) during 75-g oral glucose tolerance test, fasting plasma glucose (FPG), and glycated hemoglobin (HbA1c), in predicting risk of all-cause and cardiovascular mortality after adjusting for the influence of these glycemic measures on each other.

Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection.

The biofilm acts as a protective layer for Streptococcus suis (S. suis), contributing to the development of drug resistance and chronic infections. Autoinducer 2 (AI-2) quorum sensing represents the primary regulatory pathway governing biofilm formation in S.

The immunogenicity of PRV ΔgE/TK/UL49.5 three-gene-deleted vaccine in mice.

Background: Pseudorabies (PR) caused by the re-emerging of pseudorabies virus (PRV) variant has outbroken among PRV vaccine immunized swine in many pig farms, which has caused serious social and economic consequences since the end of 2011. The PRV UL49.5 protein can inactivate the transporter associated with antigen processing (TAP), thereby downregulating the cell surface expression of swine leukocyte antigen class I (SLA-I) to evade host immune surveillance.

Divergence of alpine plant populations of three Gentianaceae species in the Qinling sky Island.

Background: Known for their unique biodiversity, the Qinling Mountains are considered the only area in which alpine biomes occur in central China. Given that the alpine biomes are particularly sensitive to global warming, understanding how alpine plants respond to climatic fluctuations is essential for the evolution and conservation of biodiversity. To address this issue, three alpine species of the Gentianaceae (Gentiana crassuloides, G.

Genome-wide identification, characterization, and expression analysis of BZR transcription factor family in Gerbera hybrida.

Background: The BZR family genes encode plant-specific transcription factors as pivotal regulators of plant BR signaling pathways, critically influencing plant growth and development.

Results: In this study, we performed a genome-wide investigation of the BZR family gene in gerbera to identify the key components of the BR pathway that may function in petal growth. The identified BZR genes, named GhBEH1-7 (GhBEH1, GhBEH2, GhBEH3, GhBEH4, GhBEH5, GhBEH6, GhBEH7), are distributed across chromosomes 3, 5, 10, 11, 12, 14 and 15.

Chest CT characterization of children with necrotizing pneumonia due to Mycoplasma pneumoniae infection.

We summarize the chest CT manifestations and prognoses of children with Mycoplasma pneumoniae pneumonia combined with necrotizing pneumonia. We retrospectively analyzed the chest CT manifestations and prognoses of 155 cases of necrotizing pneumonia in children due to Mycoplasma pneumoniae infection and compared the differences in clinical features and laboratory indices between the group with unilateral monolobar necrosis of the lungs (Group A) and the group with unilateral multilobar and bilateral necrosis (Group B). The chest CT findings of the children in both groups revealed that the area of lung necrosis was confined to the unilateral monolobe in 124 children.

A Novel Agricultural Remote Sensing Drought Index (ARSDI) for high-resolution drought assessment in Africa using Sentinel and Landsat data.

Drought poses a significant threat to agricultural productivity in Africa due to climate variability and water scarcity. To improve drought monitoring using high-resolution remote sensing data, this paper proposes a novel Agricultural Remote Sensing Drought Index (ARSDI). Imagery from Sentinel-1(S-1), Sentinel-2 (S-2), and Landsat 8 was utilized to develop a drought monitoring system for 2017-2023, during which Egypt and Kenya experienced significant drought events.

Innovative logic "AND" gate gene circuits for bladder cancer treatment: preclinical study.

In the evolving field of precision oncology, the synthesis of gene circuits that specifically target cancer cells while preserving normal tissue marks a significant breakthrough. However, traditional approaches typically concentrate on single-gene targets, lacking the directed recognition and control among the intricate networks of signaling pathways. Our study presents a synthetic gene circuit, the Logic "AND" Gate Dual-Target Genetic Circuit (LAG-DTGC), which integrates multiple signals to achieve comprehensive reprogramming of various signaling pathways in bladder cancer (BC) cells.

Efficacy and safety of switching from entecavir to tenofovir alafenamide in chronic hepatitis B patients with low-level viremia: a real-world 48-week extension study.

Chronic hepatitis B (CHB) patients receiving entecavir (ETV) treatment might develop low-level viremia (LLV), which is proven to be associated with worse clinical outcomes, such as risk of drug-related mutations, progression to cirrhosis, and even hepatocellular carcinoma. This real-world prospective study evaluated the efficacy and safety of switching from ETV to tenofovir alafenamide fumarate (TAF) in CHB patients with LLV. From August 2020 to August 2023, 351 ETV-experienced CHB patients with LLV were enrolled from eight hospitals.

Transition-metal-free phosphorylation of polyfluoroarenes with P(O)H compounds.

Herein, a base-promoted C-P(O) bond formation method has been developed for the phosphorylation of polyfluoroarenes through selective C-F bond cleavage. The high selectivity and mild, transition-metal-free conditions of this method underscore its potential for sustainable synthesis applications. This method expands the scope of polyfluoroarene functionalization, providing a valuable tool for incorporating phosphorus motifs in complex aromatic frameworks.

Design, synthesis, and anti-inflammatory activity of 2H-1,4-benzoxazin-3(4H)-one derivatives modified with 1,2,3-triazole in LPS-induced BV-2 cells.

Given the potent anti-inflammatory properties of the 1,2,3-triazole structure and the wide use of 2H-1,4-benzoxazin-3(4H)-one in developing treatments for neurodegenerative diseases, a series of 2H-1,4-benzoxazin-3(4H)-one derivatives were synthesized by introducing a 1,2,3-triazole moiety. Screening for anti-inflammatory activity in microglial cells revealed that compounds e2, e16, and e20 exhibited the most promising effects without significant cytotoxicity. These compounds effectively reduced LPS-induced NO production and significantly decreased the transcription levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α.

Advances in Synthetic Lethality in Potential Oncology Therapeutic Approaches.

Synthetic lethality represents a novel paradigm in molecular targeted cancer therapy. In synthetic lethality, perturbation of one gene alone does not hinder cell viability, yet simultaneous perturbation of both genes results in a loss of cellular viability. The presence of gene mutations in cancer cells, as opposed to normal cells, provides an opportunity for targeted therapies that mimic the effects of the second genetic mutation, enabling selective eradication of cancer cells.

Electrochemical Difunctionalization of Alkenes.

Owing to their wide utilizations in synthesis and their products prevalence in numerous natural products, pharmaceuticals and functional materials, the alkene difunctionalization methods for the selective transformations of the olefins are important and have attracted much attention form the synthetic chemists. Among them, the electrochemical alkene difunctionalization reaction is particularly promising and has becoming a potent and sustainable tool for the selective transformations of alkenes into vicinal difunctionalized structures in organic synthesis through simultaneous incorporation of two functional groups. Herein, we summarize recent progress in the electrochemical alkene difunctionalization reactions according to the alkene difunctionalization types as well as the category of the radicals over the past five years.

A new prognostic model based on serum apolipoprotein AI in patients with HBV-ACLF and acutely decompensated liver cirrhosis.

Background/aim: To investigate the prognostic value of circulating apolipoprotein AI (apoAI) levels and develop a new prognostic model in individuals with acute-on-chronic liver failure (ACLF) and acute decompensation (AD) of liver cirrhosis caused by hepatitis B virus (HBV) infection.

Methods: Baseline levels of serum lipids were measured, and data concerning the presence of complications were collected from 561 HBV-ACLF and AD patients. Survival analysis was conducted by log-rank test.

Multi-scale comparison of the formation mechanisms in landscape genes of traditional villages.

The relationship between traditional village landscape genes and the geographical environment is closely intertwined, exhibiting notable spatial differences and cultural characteristics during scale transformations. To effectively elucidate the formation mechanisms of these landscape genes, it is essential to construct a multi-scale analytical framework that integrates multiple dimensions. This paper address these challenges by expanding the sample selection range and combining both qualitative and quantitative analyses of landscape genes across various scales.

Fault analysis and fault degree evaluation via an improved ResNet method for aircraft hydraulic system.

The hydraulic system is crucial for the safety of the aircraft, which is the key to ensuring the safety of both the aircraft and passengers. It is necessary to study and analyze the normal and fault mode of the system to provide a way for evaluating the fault degree of the hydraulic system. Therefore an improved ResNet based fault degree evaluation method was proposed to evaluate the fault degree of the aircraft hydraulic system.

The Oncopromoting Gene RBM6 Inhibits Prostate Tumour Cell Migration During Epithelial-to-Mesenchymal Transition.

RBM6, implicated in the progression of multiple tumour types but unexplored in prostate tumours, was found to indicate potential therapeutic implications due to its elevated expression in prostate tumours. To elucidate its molecular function, scratch tests, transwell migration and invasion assays were conducted, with PCR and western blot analyses verifying molecular regulatory relationships. RNA pulldown and RNA immunoprecipitation tests were also employed to investigate underlying mechanisms.

Application of gas chromatography-ion mobility spectrometry in tea (Camellia sinensis): A comprehensive review.

Gas chromatography-ion mobility spectrometry (GC-IMS) technology boasts several salient features, including fast detection, portability, simple sample preparation, and nondestructive detection, making it a highly appealing tool in tea research. By harnessing its prowess in detecting and analyzing volatile compounds present in tea, GC-IMS has found numerous applications within the broad realm of tea studies. These applications encompass discerning geographical origins, analyzing aroma profiles, classifying tea grades, distinguishing harvest seasons, monitoring aroma variations during processing, and storage, differentiating tea varieties and categories.

Soil Decomposer Can Regulate the Legacy Effect of Photodegradation on Forest Marcescent Litter Decomposition, but Emerging Microplastics Disrupt This.

Photodegradation-photochemical mineralization of standing litters-often exerts a legacy effect aiding biodegradation in soil (PLE), which is overlooked in deciduous forests containing marcescent leaves. Meanwhile, increasing anthropogenic microplastics have deposited in forests, how they would affect the PLE on subsequent litter bio-decomposition is currently unknown. Here, we employed an ultraviolet-accelerated aging chamber to replicate the abiotic photodegradation process of a naturally marcescent tree, , then manipulated mesocosm bio-incubations to quantify how decomposers (microbial alone or with soil animals) and microplastic contamination would interactively affect the PLE.