8 results match your criteria: "Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University)[Affiliation]"
Validation of an AI-Powered Automated X-ray Bone Age Analyzer in Chinese Children and Adolescents: A Comparison with the Tanner-Whitehouse 3 Method.
Adv Ther
September 2024
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Article Synopsis
- - The study evaluated a commercial AI-powered X-ray bone age analyzer's effectiveness compared to the Tanner-Whitehouse 3 (TW-3) method, finding that the AI system is both accurate and efficient in assessing bone age in children and adolescents.
- - It used radiographs from 900 patients across 30 centers in China, with six doctors independently assessing the images alongside the AI, which performed better on average than one of the raters and matched performance with others in terms of accuracy.
- - The AI analyzer achieved an impressive mean absolute error (MAE) of around 0.48 years for bone age estimates, suggesting it could enhance clinical workflow by significantly reducing the time required for evaluations.
Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study.
J Clin Endocrinol Metab
July 2023
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Context: The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited.
Objective: This study aimed to examine the effectiveness and safety of long-term PEG-rhGH in children with GHD in the real world, as well as to examine the effects of dose on patient outcomes.
Design: A prospective, observational, posttrial study (NCT03290235).
Polyethylene glycol recombinant human growth hormone in Chinese prepubertal slow-growing short children: doses reported in a multicenter real-world study.
BMC Endocr Disord
August 2022
Department of Endocrine and Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Centre for Children's Health, No.56 Nanlishi Road, Xicheng District, 100045, Beijing, China.
Background: To evaluate the effectiveness of individualized-dose polyethylene glycol recombinant human growth hormone (PEG-rhGH) for short stature.
Methods: This real-world study enrolled children with short stature in 19 hospitals throughout China. They were treated with PEG-rhGH for 6 months.
[Clinical efficacy of adaptive biofeedback training combined with oral administration of compound polyethylene glycol 4000-electrolyte powder in the treatment of children with outlet obstruction constipation: a prospective randomized controlled trial].
Zhongguo Dang Dai Er Ke Za Zhi
April 2022
Department of Gastroenterology, Henan Children's Hospital/Children's Hospital Affiliated to Zhengzhou University/Zhengzhou Children's Hospital/Zhengzhou Key Laboratory of Children's Digestive Diseases, Zhengzhou 450018, China.
Objectives: To study the clinical efficacy, advantages, and disadvantages of adaptive biofeedback training combined with oral administration of compound polyethylene glycol 4000-electrolyte powder in the treatment of children with outlet obstruction constipation (OOC).
Methods: A total of 168 children with OOC were enrolled in this prospective study. All the subjects were randomly divided into a test group and a control group based on the order of visiting time, 84 in each group.
Comparative docking studies to understand the binding affinity of nicotine with soluble ACE2 (sACE2)-SARS-CoV-2 complex over sACE2.
Toxicol Rep
October 2020
Department of Endocrinology and Metabolism, Genetics, Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University), No-33, Longhu Waihuan East Road, Zhengzhou, 450018, China.
The study aimed to validate the proficiency of nicotine binding with the soluble angiotensin-converting enzyme II receptor (sACE2) with or without SARS-CoV-2 in the context of its binding affinity. Modelled human sACE2 and the spike (S1) protein of Indian SARS-CoV-2 (INS1) docked with each other. On the other hand, nicotine docked with sACE2 in the presence or absence of SARS-CoV-2.
View Article and Find Full Text PDFSirolimus Therapy and Follow-up in a Patient with Severe Congenital Hyperinsulinism Following Subtotal Pancreatectomy.
J Clin Res Pediatr Endocrinol
February 2021
Henan Children’s Hospital (Children’s hospital affiliated to Zhengzhou University), Department of Endocrinology and Metabolism, Genetics, Zhengzhou, China
Congenital hyperinsulinism (CHI) is the most common cause of severe, persistent hypoglycemia in neonates and infants. If the patient does not respond to medical treatment the currently available treatment is subtotal pancreatectomy, but some patients still experience severe hypoglycemia after surgery. Sirolimus, a mammalian target of rapamycin inhibitor has recently been reported to be effective in the treatment of insulinoma and CHI patients.
View Article and Find Full Text PDFA novel missense COL10A1 mutation: c.2020G>A; p. Gly674Arg linked with the bowed legs stature in the Schmid metaphyseal chondrodysplasia-affected Chinese lineage.
Bone Rep
June 2020
Department of Endocrinology and Metabolism, Henan provincial key laboratory of children's genetics and metabolic diseases, Henan children's hospital (Children's hospital affiliated to Zhengzhou University), No-33, Longhu Waihuan East road, Zhengzhou 450018, China.
To evaluate the clinical-phenotypic characteristics of Schmid metaphyseal chondrodysplasia (SMCD) inflicted by a novel missense mutation of COL10A1 gene: c.2020G > A; p.Gly674Arg.
View Article and Find Full Text PDF[Advances in diagnosis and treatment of tumor lysis syndrome in children with hematological malignancies].
Zhonghua Er Ke Za Zhi
April 2019
Department of Hematology and Oncology, Beijing Children's Hospital, Capital Medical University, Beijing 100045, China.