Multi-Targeting Phytochemicals for Alzheimer's Disease.

Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate in neurons in the form of tangles. The pathophysiological pathway of AD consists of Aβ-amyloid peptides, tau proteins, and oxidative stress in neurons and increased neuro-inflammatory response. Food and Drug Administration in the United States has authorized various drugs for the effective treatment of AD, which include galantamine, rivastigmine, donepezil, memantine, sodium oligomannate, lecanemab, and aducanumab.

Multimetal exposure: Challenges in diagnostics, prevention, and treatment.

Extensive use of heavy metals has posed a serious concern for ecosystem and human too. Heavy metals are toxic in nature and their accumulation in human body causes serious disorders such as neurological disease, cardiac disease, gastrointestinal problems, skin disorders, reproductive disease, lungs diseases, and so on. Furthermore, heavy metals not only affect the human health but also have a negative impact on the economy.

Antiobesity Drug Discovery Research: Models for Shortening the Drug Discovery Pipeline.

Obesity is a growing global health problem, leading to various chronic diseases. Despite standard treatment options, the prevalence of obesity continues to rise, emphasizing the need for new drugs. methods of drug discovery research provide a time and cost-saving platform to identify new antiobesity drugs.

Isolation and identification of and its application in textile industries.

A light pink-coloured, rod-shaped, gram-negative bacterium isolated from an unproductive crude oil production area was considered as a sample for this study. The 16S rRNA gene sequence identified the isolate as . Comparing the standard colour measurement values set by the International Commission on Illumination (CIE) method confirms the colourant produced by the biomass of this microorganism as a 'light pink' colouration.

Contamination profile of DDT and HCH in surface sediments and their spatial distribution from North-East India.

Contamination status and spatial distribution of DDTs and HCHs were investigated in sediments collected from ponds and riverine system from districts Nagaon and Dibrugarh, North East India. A total of 113 surface sediment samples were collected from both the districts including 43 from ponds/wetlands and 70 from rivers/streams. Based on dry weight (dw), the mean concentration of ∑HCH and ∑DDT in sediments were found to be 287 ng/g (71.

In vitro micropropagation in Polygonatum verticillatum (L.) All. an important threatened medicinal herb of Northern India.

An ideal micropropagation method of Polygonatum verticillatum has been developed using stem disc explants. Multiple shoots were initiated from stem disc explants on Murashige and Skoog (MS) medium fortified with different concentrations (0.25-10.

Contamination levels and spatial distribution of organochlorine pesticides in soils from India.

Organochlorine pesticides, dichlorodiphenyltrichloroethane (DDT) and hexachlorocyclohexane (HCH), are potential chemical pollutants extensively used for agriculture and vector control purposes due to low cost and high effectiveness. Concentrations of HCH and DDT were determined in 175 surface soil samples from different agricultural fields, fallow and urban lands of districts Nagaon and Dibrugarh, Assam, India. The mean concentrations of total HCH and total DDT were 825 ng/g (range: 98-1945 ng/g) and 903 ng/g (range: 166-2288 ng/g) in district Nagaon while 705 ng/g (range: 178-1701 ng/g) and 757 ng/g (range: 75-2296 ng/g) in district Dibrugarh, respectively.

Organochlorine pollutants in human blood and their relation with age, gender and habitat from North-east India.

Organochlorine pesticides (OCPs) have been beneficial to man and environment but their inadvertent use has caused considerable harm to human health. Despite the proliferation of different types of pesticides, organochlorines such as HCH and DDT still account for two third of the total consumption in India because of their low cost and versatility in action again various pests. Since, Assam, a state in North-eastern part of India is an endemic area with perennial transmission where mosquito borne diseases are serious health problems; these pesticides are still being used in huge quantities in vector control as well as in agriculture.

Assessment of organochlorine pesticides in human milk and risk exposure to infants from North-East India.

Despite the worldwide ban on use of persistent organochlorine pesticides, their usage continued until recently in India, for vector-borne disease eradication programs and agricultural purposes. The concentrations of organochlorine contaminants, DDT and HCH, have been determined in human breast milk from Dibrugarh and Nagaon districts of Assam state, North-East India. The results demonstrated that the mean levels of total DDT were 3210 ng/g lipid wt.