3,004 results match your criteria: "Hemophilia Type A"
J Allergy Clin Immunol Pract
December 2024
EUCAN Medical Affairs, Takeda Pharmaceuticals International AG, Glattpark-Opfikon (Zürich), Switzerland.
Background: Hereditary angioedema (HAE) is a rare genetic disease characterized by recurrent episodes of cutaneous or subcutaneous edema. There is clinical need for treatments that reduce the rate of HAE attacks in patients.
Objectives: Primary objectives were to evaluate the effectiveness of lanadelumab on attack free rate (AFR; proportion of patients who had zero HAE attacks), and on every two weeks (Q2W) and every four weeks (Q4W) adjustments on AFR.
Haemophilia
December 2024
Institute of Experimental Hematology and Transfusion Medicine, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
Introduction: Maintaining the balance between procoagulant and anticoagulant factors is essential for effective haemostasis. Emerging evidence suggests a modulation of bleeding tendency by factors in the anticoagulant and fibrinolytic systems.
Aim: This study investigates the clinical and laboratory characteristics of a family with combined von Willebrand disease (VWD) and antithrombin (AT) deficiency.
Haemophilia
December 2024
Department of Pediatrics, Nara Medical University, Kashihara, Japan.
Introduction: Acquired haemophilia A (AHA) is characterized by the development of autoantibodies against factor VIII, reducing its activity and potentially resulting in bleeding.
Aim: To assess the characteristics of people with AHA undergoing rehabilitation and/or with low activities of daily living (ADL) scores, thereby characterizing unmet needs in the management of AHA and informing treatment optimization.
Methods: ORIHIME II, the largest epidemiological and treatment survey of AHA in Japan, is a descriptive, retrospective, observational study conducted using health claims data from April 2008 to October 2021.
Clin Appl Thromb Hemost
December 2024
Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.
Background: Prophylaxis with a von Willebrand factor (VWF) concentrate is recommended in von Willebrand disease (VWD) patients with a history of frequent and severe bleeds. Despite nosebleeds being a frequent manifestation of VWD, few studies have investigated the efficacy of factor prophylaxis in preventing nosebleeds in patients with severe VWD.
Methods: This post-hoc analysis of a prospective, 12-month, phase 3 study assessed the efficacy of wilate in the prevention of nosebleeds in 33 patients aged ≥6 years with severe type 1, type 2 or type 3 VWD.
Cureus
November 2024
Neurological Surgery, Hospital Jose Eleuterio Gonzalez, Universidad de Nuevo Leon, Monterrey, MEX.
The treatment of indirect carotid-cavernous fistula (CCF) poses a unique challenge. Currently, endovascular interventions remain the principal treatment option with high cure rates and acceptable safety profiles. The anatomical characteristics of individual cases determine the optimal vascular access routes (transvenous vs.
View Article and Find Full Text PDFThromb J
December 2024
Hemophilia Care and Research Center, Tri-Service General Hospital, Taipei, Taiwan.
Zhonghua Nei Ke Za Zhi
December 2024
Department of Medical Imaging, Henan Provincial People's Hospital; Fuwai Central China Cardiovascular Hospital (Central China Fuwai Hospital of Zhengzhou University),Zhengzhou450003, China.
Haemophilia
November 2024
Department of Pediatrics, Division of Pediatric Hematology and Oncology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Introduction: Patients with haemophilia (PWH) often have difficulty accessing dental services.
Aim: To determine the accessibility of dental care for PWH and to examine their perceptions of how coronavirus type-2 (CoV-2) disease (COVID-19) has affected their ability to access dental treatments following the pandemic.
Methods: The questionnaire survey was conducted between July 2022 and December 2022 at haemophilia treatment centres in Hungary.
Arch Med Res
November 2024
Unidad de Investigacion Médica en Trombosis, Hemostasia y Aterogénesis, Instituto Mexicano del Seguro Social, Mexico City, Mexico. Electronic address:
Background: Von Willebrand disease (VWD), is the most common inherited bleeding disorder worldwide, but its diagnosis is complicated, expensive, and poorly evaluated in several countries.
Objective: To report our long-term experience with the diagnosis of VWD based on a cost-effective strategy.
Methods: We studied 802 Mexican patients, men and women, children, and adults, with clinical suspicion of VWD.
Adv Ther
November 2024
Hematology Department, S. Bortolo Hospital, Vicenza, Italy.
BMC Health Serv Res
November 2024
Centre for Haematology, Imperial College London, London, UK.
Res Pract Thromb Haemost
October 2024
Department of Pediatric Hematology, Amsterdam University Medical Centers location University of Amsterdam, Amsterdam, the Netherlands.
Background: Inhibitor eradication to restore factor (F)VIII efficacy is the treatment goal for persons with severe hemophilia A (HA) and inhibitors. Immune tolerance induction (ITI) is demanding and successful in about 70% of people. Until now, it has remained difficult to quantify the probability of ITI success or failure, complicating the decision to initiate or not initiate ITI.
View Article and Find Full Text PDFGiven the prevalence of hematological conditions, surgeries, and trauma incidents, hemostats-therapeutics designed to control and arrest bleeding-are an important tool in patient care. The prophylactic and therapeutic use of hemostats markedly enhances survival rates and improves the overall quality of life of patients suffering from these conditions. Since their inception in the 1960s, hemostats have witnessed remarkable progress in terms of the active ingredients utilized, therapeutic outcomes, demonstrated efficacy, and the storage stability.
View Article and Find Full Text PDFHaematologica
November 2024
Division of Hematology/Oncology, Icahn School of Medicine, Mount Sinai, New York, NY.
The treatment landscape for haemophilia continues to rapidly develop, and expectations for future treatment success are high. There is limited information on the challenges to accessing new and innovative therapies. The aim of this study was to explore challenges with accessing haemophilia treatment from the perspective of healthcare professionals (HCPs).
View Article and Find Full Text PDFExpert Rev Hematol
December 2024
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Westmead, New South Wales, Australia.
Thromb Res
October 2023
Department of Pharmacy, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 10045, China. Electronic address:
Int J Surg Case Rep
October 2023
Department of Orthopedics and Traumatology, Hospital Universitario Fundación Valle del Lili, Cali, Colombia. Electronic address:
Introduction: Acquired hemophilia type A is a rare autoimmune disease characterized by bleeding episodes ranging from mild to severe, leading to significant morbidity and mortality. One of the various presentations is compartment syndrome secondary to a spontaneous hematoma.
Case Presentation: A 95-year-old woman arrived at the emergency department with a one-week history of progressive pain in the right leg, without a previous history of trauma.
Int Immunopharmacol
December 2024
Department of Hematology, Fujian Institute of Hematology, Fujian Provincial Key Laboratory of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China; Medical Technology and Engineering College of Fujian Medical University, Fuzhou, Fujian, China; Key Laboratory of Clinical Laboratory Technology for Precision Medicine (Fujian Medical University), Fujian Province University, Fuzhou, China. Electronic address:
The development of anti-factor VIII (FVIII) neutralizing antibodies (inhibitors) remains challenging complication in hemophilia A (HA) patients undergoing prophylactic FVIII replacement therapy. The pathogenesis of FVIII inhibitor formation remains unclear. Chemokine CXCL13, a key ligand for follicular helper T cells (TFHs), in the context of inhibitor development were assessed in the present study.
View Article and Find Full Text PDFWomens Health Rep (New Rochelle)
September 2024
Division of Hematology-Oncology, Department of Pediatrics, University of Michigan Medical School, Ann Arbor, Michigan, USA.
J Pak Med Assoc
October 2024
Centre for Hereditary Blood Diseases, Basra Maternity and Children Hospital.
Objective: To evaluate the level of care available for haemophilia patients.
Methods: The descriptive, retrospective analytical study was conducted from December 15, 2020, to March 1, 2021, after approval from the Mustansiriyah University, Baghdad, Iraq, and comprised data from 3 haemophilia treating centres in Iraq participating in the World Bleeding Disorders Registry. The data collected related to patients with haemophilia A and B enrolled in the registry since March 2018, and included age at diagnosis, type of haemophilia, disease severity, age at first bleed and at first joint bleed, type of replacement therapy and outcome.
Healthcare (Basel)
October 2024
Orthopedics and Traumatology Clinic, IRCCS Policlinico San Matteo Foundation, 27100 Pavia, Italy.
Background: Hemophilia type A and B is associated with spontaneous bleeding in muscle tissues and joints. Acute hemarthrosis, representing 70-80% of all bleedings in severe hemophilia patients, is extremely painful. When surgical procedures are needed in hemophiliac patients, perioperative management should be planned with a multidisciplinary team.
View Article and Find Full Text PDFHaemophilia
November 2024
Department of Hematology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Res Pract Thromb Haemost
August 2024
Division of Hematology, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Front Pediatr
September 2024
Indiana Hemophilia & Thrombosis Center, Indianapolis, IN, United States.