1 results match your criteria: "Hematology Department of TCM Hospital of Zhejiang Province[Affiliation]"
[Study on matrine alleviating retinoic acid resistance in acute promyelocytic leukemia].
Zhonghua Xue Ye Xue Za Zhi
May 2011
Hematology Department of TCM Hospital of Zhejiang Province, Hangzhou 310006, China.
Objective: To explore the role of matrine (MAT) alleviating all-trans retinoic acid (ATRA) resistance in acute promyelocytic leukemia (APL) and its mechanism.
Methods: ATRA sensitive strain of APL (NB4) and resistant strain (NB4-R1, NB4-R2) were used in this study. The low toxic dosage of MAT was established by MTT test, and ATRA IC(50) of the cell strains (cultured with or without 0.