The efficacy of Veliparib in combination with chemotherapy in the treatment of lung cancer: systematic review and meta-analysis.

Objective: This meta-analysis aims to examine the effectiveness of veliparib, a poly ADP-ribose polymerase inhibitor, in combination with chemotherapy in treating bronchogenic carcinoma.

Methods: PubMed, Cochrane, Scopus, and Web of Science were searched for eligible randomized controlled trials comparing veliparib plus chemotherapy to standard chemotherapy in adult lung cancer patients, until July 2023. The main outcomes were overall survival (OS) and progression-free survival (PFS).

Observation of the decay.

Using proton-proton collision data corresponding to an integrated luminosity of collected by the CMS experiment at , the decay is observed for the first time, with a statistical significance exceeding 5 standard deviations. The relative branching fraction, with respect to the decay, is measured to be , where the first uncertainty is statistical, the second is systematic, and the third is related to the uncertainties in and .

Energy management system for multi interconnected microgrids during grid connected and autonomous operation modes considering load management.

This study focuses on improving power system grid performance and efficiency through the integration of distributed energy resources (DERs). The study proposes an artificial intelligence (AI) based effective approach for economic dispatch and load management for three linked microgrids (MGs) that operate in both grid-connected and autonomous modes. A day-ahead scheduling method is suggested to calculate the optimal set points for various energy sources in MGs considering various system constraints for safe operation.

Dexmedetomidine Versus Fentanyl on Time to Extubation in Patients with Morbid Obesity Undergoing Laparoscopic Sleeve Gastrectomy.

Background: Sleeve gastrectomy (SG) is an effective method for managing obesity. While opioids are used for their hemodynamic stability and their ability to reduce intraoperative stress, they also have reported side effects. Dexmedetomidine (DEX), an α2 adrenergic receptor agonist, is noted for its analgesic and anesthetic-sparing effects, leading to a higher quality of recovery.

Mechanical performance and dimensional stability of Washingtonia/Kenaf fibres-based epoxy hybrid composites.

In this study, Washingtonia fibres (AW) and Kenaf fibres (KF) were utilized as environmentally friendly fillers to improve the quality of the resin matrix. The mechanical, morphological, and physical properties of the WA/KF biocomposites were assessed throughout this research. The mechanical tests (tensile strength and moduli, elongation at break, flexural strength along with moduli, and the impact properties) were carried out.

Efficacy and safety of combined topical ethinylestradiol with minoxidil versus topical minoxidil in female pattern hair loss. A trichoscopic randomized controlled clinical study.

Background: Female pattern hair loss (FPHL) is widely common and negatively impacts the quality of life. FPHL is more challenging to treat than male pattern hair loss with minoxidil being the gold standard treatment. Several studies used 17α-estradiol solution for treating FPHL with variable results either alone or combined with minoxidil.

Validity of Airway Ultrasound in Correlation with Cormack-Lehane Grading in Obese Patients: A Cross-Sectional Study.

Background: Ultrasound (US) of the upper airway has the potential to be a valuable addition to traditional clinical evaluation methods.

Objectives: This work aimed to assess the validity of US in correlation with Cormack-Lehane grading (CLG) in obese patients.

Methods: This cross-sectional work was performed on 78 patients ranging in age between 21 and 60 years, both genders with the American Society of Anesthesiologists (ASA) II-III individuals and body mass index (BMI) 30 kg/m² or more, under general anesthesia with endotracheal tube placement.

Anthelmintic Activity of Carica papaya Leaf Extracts: Insights from In Vitro and In Silico Investigations.

Introduction: Helminthiasis remains a major global health concern. Exploring natural alternatives due to drug resistance and synthetic drug side effects has become increasingly urgent.

Method: This study investigates the anthelmintic potential of Carica papaya leaf extracts (CPLE) against Allolobophora caliginosa, along with elucidating the underlying structural alterations and molecular interactions.

Urchin-like WO Particles Form Honeycomb-like Structured PLA/WO Nanocomposites with Enhanced Crystallinity, Thermal Stability, Rheological, and UV-Blocking and Antifungal Activity.

The development of poly(lactic acid) (PLA) nanocomposites incorporating urchin-like WO particles through a cost-effective solution-casting method has led to significant enhancements in structural, thermal, optical, and rheological properties. The incorporation of these WO particles up to 7 wt% resulted in the formation of an irregular honeycomb-like morphology with broad pore sizes ranging from 14.1 to 24.

Synthesis, Anti-Cancer Activity, Cell Cycle Arrest, Apoptosis Induction, and Docking Study of Fused Benzo[]chromeno[2,3-]pyrimidine on Human Breast Cancer Cell Line MCF-7.

Breast cancer is the predominant form of cancer among women and ranks as the second most prevalent cancer globally, affecting both developed and less developed countries. Presently, accessible cancer treatment methods either employ recently created, secure, and efficient chemotherapeutic medications or directly target innovative pathways that cause apoptosis. One of the indirect strategies for treating this fatal illness has mostly depended on its essential role in cell cycle arrest and apoptosis induction, as well as the antagonistic interaction between the Bcl-2 and Mcl-1 proteins, in order to avert major health repercussions.

Amputated life-testing based on extended Dagum percentiles for type of group inspection plans: optimal sample sizes, termination time ratios analysis.

This paper introduces a novel approach to life-testing using Extended Dagum (EXD) percentiles within the framework of group inspection plans. The methodology focuses on optimizing sample sizes and analyzing termination time ratios to enhance the reliability of quality control procedures. By leveraging the flexibility of the EXD distribution, the proposed approach accurately models complex survival data, accommodating heavy-tailed characteristics often encountered in practice.

A new class of Lindley distribution: System reliability, simulation and applications.

This paper presents a new probability distribution called the DUS Lindley distribution, created by applying the DUS transformation to the traditional Lindley distribution. The study provides an in-depth analysis of the distribution's statistical properties. These properties include a variety of statistical measures such as the probability density function, cumulative distribution function, failure rate, survival function, reverse hazard function, Mills ratio, mean residual life, mean past life, moments, conditional moments, characteristic function, order statistics, entropy measures, likelihood ratio test and Lorenz and Bonferroni curves.

Species-specific ecotoxicity of platinum nanoparticles to two cyanobacteria.

Platinum nanoparticles (PtNPs) are one of the widely used NPs, which contribute to potential risks to the aquatic ecosystem. However, PtNPs toxicity in phytoplankton remains inadequately understood, with significant gaps in knowledge regarding their biochemical bases and species-specific responses. Herein, we investigated the impact of PtNPs on two cyanobacterial species (Anabaena laxa and Nostoc muscorum) to explore the harmful pathways triggered by PtNPs in cyanobacteria, which may help in selecting appropriate biomarkers for PtNPs pollution in aquatic environments.

Group acceptance sampling plan based on truncated life tests for Type-I heavy-tailed Rayleigh distribution.

This study on the Type-I heavy-tailed Rayleigh (TI-HTR) distribution is a special case of Type-I heavy-tailed (TI-HT) family of distributions was studied. The characteristics were derived, including the moment and its measures, quantile function, reliability measures, and other statistical properties as well as parameter estimation using the maximum likelihood method and penalized likelihood estimation. The behavior of its various functions were shown graphically.

Synthesis and characterization of some new Schiff base azo disperse dyes based on chromene moiety for simultaneous dyeing and antimicrobial finishing.

New azo Schiff base disperse dyes based on a chromene moiety were synthesized by reacting (2-amino-7-hydroxy-4-(4-methoxyphenyl)-4 H-chromene-3 carbonitrile) and(2-amino-4-(3,4-dimethoxyphenyl)-7-hydroxy-4 H-chromene-3-carbonitrile), with vanillin and ninhydrin, producing new chromene Schiff base derivatives, which in turn were coupled with 2-chloro-4-nitroaniline diazonium salt to give new 4 azo disperse dyes (1-4). The structures of the prepared dyes were confirmed using elemental analysis, HNMR spectroscopy, mass spectrometry, and IR. The synthesized dyes were applied to polyester and nylon fabrics using different dyeing techniques: high temperature- high pressure, and ultrasonic dyeing methods.

Subclinical left ventricular dysfunction and laboratory predictor of activity in children with ulcerative colitis: A single-centre study.

Aim: We aimed to detect subclinical cardiac impairment in children with ulcerative colitis (UC) and test the association between absolute monocytic count (AMC) and lymphocyte-to-monocyte ratio (LMR) with disease activity.

Methods: A group of children with UC and a comparable group as healthy controls were included. All children underwent history-taking, clinical examination and blood testing for complete blood counts with white blood cell differentials, LMR and erythrocyte sedimentation rate (ESR).

Rethinking polyiodides: the role of electron-deficient multicenter bonds.

Despite a bicentennial history, the interest in polyiodides and related systems still flourishes. The chemical puzzle provided by the intricate nature of chemical bonding in these polyanions remains challenging these days. The advent of the halogen bond and the spreading interest in supramolecular interactions of halogen-based systems promoted further recent interest.

Cassia alata: Helminth and Bacteria Fighter.

Introduction: The concurrent presence of helminthiasis and bacterial diseases imposes a dual burden, worsening the challenges associated with each condition independently. This cohabitation intensifies the economic impact, creating a compounding effect on public health and economic well-being.

Method: Phytochemical analysis of Cassia alata Extract (CAE) using infrared spectroscopy has revealed the presence of various functional groups.

Synergistic effects of thermally reduced graphene oxide/zinc oxide composite material on microbial infection for wound healing applications.

Infections originating from pathogenic microorganisms can significantly impede the natural wound-healing process. To address this obstacle, innovative bio-active nanomaterials have been developed to enhance antibacterial capabilities. This study focuses on the preparation of nanocomposites from thermally reduced graphene oxide and zinc oxide (TRGO/ZnO).

Explainable AI and optimized solar power generation forecasting model based on environmental conditions.

This paper proposes a model called X-LSTM-EO, which integrates explainable artificial intelligence (XAI), long short-term memory (LSTM), and equilibrium optimizer (EO) to reliably forecast solar power generation. The LSTM component forecasts power generation rates based on environmental conditions, while the EO component optimizes the LSTM model's hyper-parameters through training. The XAI-based Local Interpretable and Model-independent Explanation (LIME) is adapted to identify the critical factors that influence the accuracy of the power generation forecasts model in smart solar systems.