Evaluation of Vincamine Loaded with Silver Nanoparticles as a New Potential Therapeutic Agent Against Ehrlich's Solid Carcinoma in Mice.

Vincamine, a monoterpenoid indole alkaloid with vasodilatory properties, is extracted from the leaves of . The present study aimed to determine the potential anticancer effects of vincamine loaded in silver nanoparticles (VCN-AgNPs) in mice with Ehrlich solid carcinoma (ESC). After tumor transplantation, the mice were divided into five groups: ESC, ESC+Cisplatin (CPN; 5 mg/kg), ESC+VCN (40 mg/kg), ESC+AgNPs (6 mg/kg), and ESC+VCN-AgNPs (20 mg/kg).

Antioxidant, Anti-Alzheimer's, anticancer, and cytotoxic properties of peanut oil: , in silico, and GC-MS analysis.

Introduction: Peanut oil is valued for its mild flavor, rich phytochemical content, therapeutic potential, and associated health benefits. This study aims to analyze the chemical composition, antioxidant properties, and anti-Alzheimer's potential of Algerian peanut oil using both experimental and computational approaches. The goal is to evaluate its suitability for pharmaceutical applications, particularly for its antioxidant, anti-Alzheimer, and anticancer properties.

Design of a square-horn hybrid plasmonic nano-antenna array using a flat lens for optical wireless applications with beam-steering capabilities.

This paper introduces a Hybrid Plasmonic Nano-Antenna (HPNA) with a gradient-index dielectric flat lens modeled with different materials to enhance and steer the radiation in a particular direction based on a phase shift array. Firstly, the design of hybrid plasmonic Nano-Antenna (NA) is introduced and analyzed considering different horn-shapes such as diamond, hexagonal, circular, rectangular, and square shapes. The commercial software Computer Simulation Technology-Microwave Studio (CST-MWS) is used to analyze the radiation characteristics of the plasmonic NAs at the standard telecommunication wavelength of 1,550 nm.

Comparative effectiveness of lifestyle interventions on children's body composition management: A systematic review and network meta-analysis.

Purpose: This study aimed to provide comparative evidence on the effectiveness of various lifestyle interventions on body composition management for preschool and school-aged children.

Methods: PubMed (MEDLINE), Embase, CINAHL, and Web of Science were systematically searched for this network meta-analysis. Randomized controlled studies (RCTs) that included children aged 4-12 years with no physical or mental conditions; performed at least 1 type of lifestyle intervention; reported change in body mass index (BMI), BMI z-score, or body fat percentage (BFP); and were published between January 2010 and August 2023 were included.

Percutaneous Coronary Intervention for Atherosclerotic Coronary Artery Disease After Arterial Switch Operation: A Case Report.

Late coronary complications after an arterial switch operation (ASO) may occur due to vessel kinking, compression resulting from growth of the great vessels, ostial fibro-intimal thickening after reimplantation or possibly secondary to accelerated atherosclerosis. Given that many of these patients are asymptomatic, adult ASO survivors require special attention and an individualised approach to the early detection of coronary artery disease. Most previously reported cases of coronary artery disease after an ASO have been managed surgically.

Sociodemographic Predictors of Keratoconus (Severity, Treatment, and Progression) in a Tertiary Center in New York City.

Purpose: To identify sociodemographic factors as predictors of keratoconus severity, progression, disease outcomes, and appropriate management in a tertiary care ophthalmology institute in the New York City metropolitan area.

Methods: This is a retrospective chart review. Patients with keratoconus presenting at a tertiary eye institute in an urban setting seen between 2015 and 2022 were included.

A deep learning approach for ovarian cancer detection and classification based on fuzzy deep learning.

Different oncologists make their own decisions about the detection and classification of the type of ovarian cancer from histopathological whole slide images. However, it is necessary to have an automated system that is more accurate and standardized for decision-making, which is essential for early detection of ovarian cancer. To help doctors, an automated detection and classification of ovarian cancer system is proposed.

Understanding Voriconazole Metabolism: A Middle-Out Physiologically-Based Pharmacokinetic Modelling Framework Integrating In Vitro and Clinical Insights.

Background And Objective: Voriconazole (VRC), a broad-spectrum antifungal drug, exhibits nonlinear pharmacokinetics (PK) due to saturable metabolic processes, autoinhibition and metabolite-mediated inhibition on their own formation. VRC PK is also characterised by high inter- and intraindividual variability, primarily associated with cytochrome P450 (CYP) 2C19 genetic polymorphism. Additionally, recent in vitro findings indicate that VRC main metabolites, voriconazole N-oxide (NO) and hydroxyvoriconazole (OHVRC), inhibit CYP enzymes responsible for VRC metabolism, adding to its PK variability.

Energy management and demand side management framework for nano-grid under various utility strategies and consumer's preference.

This research proposes a day-ahead scheduling utilizing both demand side management (DSM), and Energy Management (EM) in a grid-tied nanogrid comprises of photovoltaic, battery, and diesel generator for optimizing the generation cost and the energy not supplied (at grid-outage). Wider terminology is introduced to combine both load controllability (considered in traditional DSM), and interval capability to accommodate additional loads defined as flexible, non-flexible, and semi-flexible intervals. Moreover, the user selection for EM or combined operation of EM with DSM at different degrees of interval flexibility is defined as user preference.

Mitoepigenetics pathways and natural compounds: a dual approach to combatting hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is a leading liver cancer that significantly impacts global life expectancy and remains challenging to treat due to often late diagnoses. Despite advances in treatment, the prognosis is still poor, especially in advanced stages. Studies have pointed out that investigations into the molecular mechanisms underlying HCC, including mitochondrial dysfunction and epigenetic regulators, are potentially important targets for diagnosis and therapy.

Optimizing data transmission in 6G software defined networks using deep reinforcement learning for next generation of virtual environments.

Data transmission of Virtual Reality (VR) plays an important role in delivering a powerful VR experience. This increasing demand on both high bandwidth and low latency. 6G emerging technologies like Software Defined Network (SDN) and resource slicing are acting as promising technologies for addressing the transmission requirements of VR users.

Synergistic Effect of Arbuscular Mycorrhizal Fungi and Germanium on the Growth, Nutritional Quality, and Health-Promoting Activities of L.

Arbuscular mycorrhizal fungi (AMF) and the antioxidant germanium (Ge) are promising tools for boosting bioactive compound synthesis and producing healthier foods. However, their combined effect remains unexplored. This study demonstrates the synergistic impact of AMF and Ge on the growth, metabolite accumulation, biological activities, and nutritional qualities of L.

Extract as a Potential Anticoccidial Agent: Evidence of Its MUC2 Regulatory Impact in Murine Jejunum.

is a parasite that causes coccidiosis in a variety of animals, leading to nutritional imbalances, issues with food digestion and absorption, low weight, and intestinal inflammation of varying degrees in its hosts. Anticoccidial medication resistance has become a significant obstacle to disease control efforts, leading to a renewed focus on discovering novel chemicals for alternative therapeutic approaches. The purpose of this study was to determine the efficacy of extract (HpE) in treating eimeriosis in mice.

Modeling of methane emissions from waste disposal sites at selected Egyptian governorates and potential energy production from waste-to-energy projects.

Waste and energy sectors have significant contributions to the greenhouse gas (GHG) emissions caused primarily by the population expansion. Waste-to-Energy (WtE) is introduced to address the issue raised by both sectors simultaneously through utilization of the potential energy stored in municipal solid waste (MSW) as well as offsetting GHG emissions. Limited research have been conducted in Egypt to assess the current situation of MSW management and associated methane emissions.

Efficacy, safety, and impact on procedural outcomes of local anesthesia in endoscopic submucosal dissection: a systematic review and meta-analysis.

Background: Endoscopic submucosal dissection (ESD) has revolutionized the treatment of early stage gastrointestinal cancers. However, ESD can be associated with increased postprocedural pain and higher complication rates. This systematic review and meta-analysis evaluated the efficacy and safety of local anesthesia.

Evaluation of insulin-like growth factor-1 in apparently healthy infants and prepubertal Egyptian children with different nutritional statuses.

Objectives: to estimate insulin-like growth factor-1 (IGF-1) levels in apparently healthy infants and prepubertal children and compare results among different nutritional statuses.

Methods: Our cross-sectional work is a sub-study of a screening project for anemia and nutritional status. We included 252 apparently healthy infants and children with a mean age of 3.