Evaluation of diagnostic performances of Pro-neurotensin and Heart-type fatty acid binding protein as reliable biomarkers for cardiovascular diseases.

Aim: In 2019, cardiovascular diseases accounted for 32% of global deaths. So, early detection of cardiac disorders is crucial. The study aimed to examine the suitability of Pro-neurotensin and Heart-type fatty acid binding protein as dependable biomarkers for cardiac patients with Heart failure as a primary diagnosis.

Examining the associations between emotionally charged reactions toward climate change and self-care, quality of life among older adults, coping mechanisms, and pro-environmental practices.

Aim: To examine the associations between emotionally charged reactions to climate change, self-care, quality of life among older adults, coping mechanisms, and pro-environmental practices.

Background: Older adults often face unique challenges in coping with climate change and its detrimental effect on self-care and quality of life. They may be particularly vulnerable to this pressing global issue.

Fusing CNNs and attention-mechanisms to improve real-time indoor Human Activity Recognition for classifying home-based physical rehabilitation exercises.

Physical rehabilitation plays a critical role in enhancing health outcomes globally. However, the shortage of physiotherapists, particularly in developing countries where the ratio is approximately ten physiotherapists per million people, poses a significant challenge to effective rehabilitation services. The existing literature on rehabilitation often falls short in data representation and the employment of diverse modalities, limiting the potential for advanced therapeutic interventions.

Unraveling the role of LncRNAs in glioblastoma progression: insights into signaling pathways and therapeutic potential.

Glioblastoma (GBM) is one of the most aggressive types of brain cancer, characterized by its poor prognosis and low survival rate despite current treatment modalities. Because GBM is lethal, clarifying the pathogenesis's underlying mechanisms is important, which are still poorly understood. Recent discoveries in the fields of molecular genetics and cancer biology have demonstrated the critical role that non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), play in the molecular pathophysiology of GBM growth.

Fluorescent antimicrobial hydrogel based on fluorophore N-doped carbon dots originated from cellulose nanocrystals.

The current study represents a unique fabrication strategy for preparation of fluorescent hydrogels via incorporation of fluorescent quantum dots (QDs) as fluorophore entities into chitosan as a gelling matrix. QDs identified as carbon quantum dots (CQDs) & nitrogen containing carbon quantum dots (NCQDs) were preliminary synthesized from cellulose nanocrystals (CNCs) and cationic cellulose nanocrystals (CCNCs), respectively. Cationic CNCs was prepared via chemical grafting with poly-di-allyl dimethyl ammonium chloride (CNCs-g-poly-DADMAC) through free chain polymerization reaction.

The efficacy of behavioral sleep intervention on sleep problems among children with attention-deficit hyperactivity disorder: A randomized controlled trial.

Background: Attention-deficit hyperactivity disorder (ADHD), affecting 5% of global children, presents inattention, hyperactivity, and impulsivity. Sleep problems, prevalent in 70% of cases, exacerbate long-term psychosocial challenges.

Aim: This study aimed to assess the efficacy of behavioral sleep intervention in alleviating sleep problems, enhancing quality of life (QoL), and reducing ADHD symptom severity among children diagnosed with ADHD.

Bio-fabrication of biologically active copper nanocomposite.

Green routes for nucleation of nanostructures are recently applied for the biomedical applications, due to their affinity and feasibility. For instance, copper nanostructures are applicable for inhibition of microbial infections and ulcers. Hereby, this work is aimed at investigation for the possible contribution of Sidr honey (SH) in the formation of copper based-nanocomposites (Cu@SH).

Optimizing energy-efficient grid performance: integrating electric vehicles, DSTATCOM, and renewable sources using the Hippopotamus Optimization Algorithm.

The rapid increase in renewable energy integration and electric vehicle (EV) adoption creates significant challenges for the stability and efficiency of power distribution networks. This study addresses the need for optimized placement and sizing of Electric Vehicle Charging Stations (EVCSs), photovoltaic (PV) systems, and Distribution Static Compensators (DSTATCOMs) to enhance grid performance. The motivation for this work arises from the fluctuating nature of renewable energy generation and the unpredictable demands of EV charging, which strain existing infrastructure.

A New Guiding Suturing Technique for Reshaping of the Antihelix in Patients with Prominent Ears.

Background: Prominent ears are the most common congenital anomaly of the head and neck. A complete understanding of the definition of prominent ears is necessary. The present retrospective study described guiding sutures to hold the antihelix in a temporary corrected position before placing the permanent Mustardé sutures.

Estrogen: the forgotten player in metaflammation.

Metaflammation is low-grade inflammation triggered by chronic metabolic imbalance and caused by dysregulated metabolites in metabolic inflammatory syndrome (MIS), which includes four diseases: obesity, type 2 diabetes mellitus (T2DM), atherosclerosis (AS), and nonalcoholic fatty liver diseases (NAFLD, recently proposed to be replaced by metabolic dysfunction-associated steatotic liver disease, MASLD). These diseases exhibit apparent sex dimorphism as regards MIS. Estrogen not only plays a crucial role in gender differences in adults but also possesses an anti-inflammatory effect on many metabolic diseases.

Cervical cancer screening uptake in Arab countries: a systematic review with meta-analysis.

Background: Cervical cancer, though one of the most common cancers affecting women globally, holds immense potential for prevention through screening. Therefore, we conducted this meta-analysis to assess the rate of cervical cancer screening in Arab countries and identify barriers among those who did not participate.

Methods: A comprehensive search was conducted from January 1st to June 1st,2024, including all observational studies that reported cervical cancer screening uptake in any Arab country.

Cranial reconstruction utilizing polymeric implants in two different designs: finite element investigation.

Introduction: Impact loads applied to the human head can result in skull fractures or other injuries that require a craniectomy. The removed portion is replaced with biological or synthetic materials using cranioplasty surgery. Titanium has been the material of choice for cranial implants due to its superior properties and biocompatibility; however, its issues have prompted the search for substitute materials (e.

Volatiles extracted from Melaleuca Rugulosa (Link) Craven leaves: comparative profiling, bioactivity screening, and metabolomic analysis.

Background: Melaleuca species (family Myrtaceae) are characterized by their wide-ranging applications as antimicrobials and in skin-related conditions. Herein, we estimated the volatile profile and biological significance of M. rugulosa (Link) leaves for the first time supported by a dereplication protocol.

Thermo-fluid characteristics and exergy analysis of a twisted tube helical coil.

In the present investigation, the exergy of an innovative technique involving the integration of curved helical tubes with twisted passages was experimentally presented. This technique aims to improve the thermofluid characteristics by involving the swirl intensity of fluid flow in a twisted tube helical coil (TTHC). Six identical geometries with different pitch ratios Υ of 36 mm, 54 mm, and ∞ (smooth/no twisted) were experimentally explored at two different inner tube profiles of triangular and square cross-sections in counter flow arrangements.

Energy saving analysis for pump-motor set in water purification plant using variable speed drive.

The induction motor is known to be the most reliable motor in the industry and is also the most energy-consuming load worldwide. It is noticeable in some production areas that the use of a high-capacity induction motor is not required at some operating times, and therefore it is important to control the speed of the induction motor to suit the operating requirements and obtain highly efficient performance. This paper presents a case study of a drinking water purification plant that uses a variable speed drive (VSD) as a speed controller for one of its induction motors to drive the pump.

Sustainable nanocellulose coating for EPS geofoam extracted from agricultural waste.

Expanded polystyrene (EPS) geofoam blocks are gaining acceptance across industries due to their low density, insulation properties, strength, compressibility, and shock absorption under dynamic loads. The effective application of EPS is impeded by restrictions imposed by using conventional polymer-based synthetic geomembrane insulation ought for protection. Meanwhile, the production process of the geomembrane has detrimental environmental impacts, incurs high costs, and limits the utilization of EPS blocks in various applications.

Depression in geriatrics: a systematic review and meta-analysis of prevalence and risk factors in Egypt.

Background: Depression is the most common psychiatric disorder in older adults, even though it is commonly misdiagnosed and undertreated, leading to exacerbations of preexisting medical conditions and even a higher mortality rate. In the present systematic review with meta-analysis, we quantify the magnitude of depression and its associated risk factors among the older adult population in Egypt.

Methods: A thorough literature search was performed from 2010 up to October 2023.

Exploring the complexity, treatment challenges, and outcomes in pediatric nodular lymphocyte predominant Hodgkin lymphoma: a perspective from a low-middle-income country.

Background: In children, nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is an uncommon subtype of Hodgkin lymphoma. Given the lack of data on the best chemotherapy regimen, there is a knowledge gap in best management.

Methods: This retrospective study included all pediatric patients with NLPHL diagnosed and treated at the Children's Cancer Hospital, Egypt (2007-2018).

CYP3A4*1B and CYP3A5*3 SNPs significantly impact the response of Egyptian candidates to high-intensity statin therapy to atorvastatin.

Background: A single nucleotide polymorphism (SNP) is a variation in the DNA sequence that results from the alteration of a single nucleotide in the genome. Atorvastatin is used to treat hypercholesterolemia. It belongs to a class of drugs called statins, which lower elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C).

Molecular docking and molecular dynamics of hypoxia-inducible factor (HIF-1alpha): towards potential inhibitors.

HIF-1α is a primary regulator in the adaptation of cancer cells to hypoxia. The aim was to find out new inhibitors of the HIF-1α. A molecular dynamic (MD) simulation performed on HIF-1α showed stable dynamic features.

Anti‑phenolic glycolipid‑I seropositivity among household contacts of leprosy patients in Egypt.

Leprosy is a chronic, debilitating disease lacking a definitive diagnostic biomarker. Serum anti-phenolic glycolipid-I (PGL-I) IgM antibody level is considered an important diagnostic and prognostic marker for leprosy patients. However, there is limited evidence on the role of anti-PGL-I IgM antibody level as early predictive biomarker of subclinical infection among Egyptian household contacts of leprosy patients.

A Modified Johnson Cook Model-Based Kalman Filter Method to Determine the Hot Flow Behavior of Sustainable AA6082 Al Alloy.

AA6082 alloys play a significant role in advancing sustainable development goals (SDGs) by contributing to environmental sustainability, economic growth, and social well-being. These alloys are highly recyclable and align with SDG 12 by promoting resource efficiency and reducing waste. Their application in lightweight vehicles and improving energy efficiency in construction supports SDG 9 and SDG 11, as they help reduce carbon emissions and enhance the sustainability of urban environments.