Comparative study between high and low dose methylene blue infusion in septic cancer patients: a randomized, blinded, controlled study.

Purpose: Septic shock is a common threat, and is the primary cause of death in almost all critical care units. Mortality of septic shock remains exceedingly high. The early use of methylene blue (MB) in different doses as adjunctive to vasopressors has promising results.

N-Acetyl cysteine exhibits antimicrobial and anti-virulence activity against Salmonella enterica.

Salmonella enterica is a common foodborne pathogen that causes intestinal illness varying from mild gastroenteritis to life-threatening systemic infections. The frequency of outbreaks due to multidrug-resistant Salmonella has been increased in the past few years with increasing numbers of annual deaths. Therefore, new strategies to control the spread of antimicrobial resistance are required.

Ln-MOF in production of durable antimicrobial and UV-Protective fluorescent cotton fabric for potential application in military textiles.

Industrialization of military textiles faces many challenges and some requirements such as durability, protection and suitability for hostile environment must be provided. Herein, fluorescent protective cotton with ultraviolet radiation (UVR)-protection and antimicrobial property was currently prepared via the immobilization of lanthanide-metal organic framework (Ln-MOF). Cotton fabrics were primarily activated via cationization process with 3-Chloro-2-hydroxypropyltrimethyl ammonium chloride to obtain the cationized cotton (Q-cotton).

Integrating Wi-Fi, Li-Fi, and BPL Technologies for a Secure Indoor Communication System.

In today's digital age, there is an increasing demand for integrated wireless and wired technologies; however, there is a difficulty in achieving secure and reliable communications within buildings and facilities. This paper presents a proposal for maintaining the infrastructure while expanding it to implement communication technologies with high transmission and reception speeds and high levels of data confidentiality to enhance the operational efficiency of organizations. Three main technologies have emerged as promising solutions for this purpose: Wi-Fi, Li-Fi, and BPL.

Personalized treatment approaches in hepatocellular carcinoma.

Personalized medicine is an emerging field that provides novel approaches to disease's early diagnosis, prevention, treatment, and prognosis based on the patient's criteria in gene expression, environmental factors, lifestyle, and diet. To date, hepatocellular carcinoma (HCC) is a significant global health burden, with an increasing incidence and significant death rates, despite advancements in surveillance, diagnosis, and therapeutic approaches. The majority of HCC lesions develop in patients with liver cirrhosis, carrying the risks of mortality associated with both the tumor burden and the cirrhosis.

Two-stage multi-objective framework for optimal operation of modern distribution network considering demand response program.

To improve the inadequate reliability of the grid that has led to a worsening energy crisis and environmental issues, comprehensive research on new clean renewable energy and efficient, cost-effective, and eco-friendly energy management technologies is essential. This requires the creation of advanced energy management systems to enhance system reliability and optimize efficiency. Demand-side energy management systems are a superior solution for multiple reasons.

Efficacy and Safety of Continuous vs Intermittent Linezolid Infusion in Critically Ill Patients with Septic Shock.

Unlabelled: The synthetic antimicrobial agent Linezolid effectively penetrates many tissues and exhibits effectiveness against drug-resistant Gram-positive bacteria. This agent's pharmacokinetic qualities cast doubt on the need for intravenous treatment in cases of serious illness. For its time-dependent action to have an impact, serum levels must stay above the minimum inhibitory concentration throughout the dosage interval.

Harnessing the power of microbial fuel cells as pioneering green technology: advancing sustainable energy and wastewater treatment through innovative nanotechnology.

The purpose of this review is to gain attention about intro the advanced and green technology that has dual action for both clean wastewater and produce energy. Water scarcity and the continuous energy crisis have arisen as major worldwide concerns, requiring the creation of ecologically friendly and sustainable energy alternatives. The rapid exhaustion of fossil resources needs the development of alternative energy sources that reduce carbon emissions while maintaining ecological balance.

Design and synthesis of antiproliferative 2-oxoindolin-3-ylidenes incorporating urea function with potential VEGFR-2 inhibitory properties.

Targeted therapy is preferable over other therapeutics due to its limitation of drawbacks and better pharmaceutical outcomes. VEGF and its receptors have been observed to be hyper-activated in many cancer types and are considered promising targets for assigning anticancer agents. The current study is directed towards synthesis of novel antiproliferative 2-oxoindolin-3-ylidenes incorporating urea function with VEGFR-2 properties.

Comparative effectiveness of school-based obesity prevention programs for children and adolescents: a systematic review and network meta-analysis.

Introduction: While many randomized controlled trials (RCTs) have demonstrated the positive effects of school-based programs in reducing body fat among children and teenagers, there is no conclusive evidence to indicate that one approach is superior to another, largely due to the lack of direct and indirect comparisons. This study evaluated the relative effectiveness of various school-based obesity prevention initiatives in improving body mass index (BMI) among children and adolescents using network meta-analysis.

Methods: Searches included four databases focusing on articles published in English between the years 2002 and 2024.

Internal Fixation for Unstable Distal Ulnar Fractures by 2.7 mm Semitubular Hook Plate.

The purpose of this study is to investigate the outcomes of the use of a 2.7 mm semitubular hook plate for internal fixation of unstable metaphyseal ulnar fractures. Between January 2015 and July 2019, 30 consecutive patients with a recent unstable distal ulnar fracture were included in this prospective case series.

Leveraging AHP and transfer learning in machine learning for improved prediction of infectious disease outbreaks.

Infectious diseases significantly impact both public health and economic stability, underscoring the critical need for precise outbreak predictions to effictively mitigate their impact. This study applies advanced machine learning techniques to forecast outbreaks of Dengue, Chikungunya, and Zika, utilizing a comprehensive dataset comprising climate and socioeconomic data. Spanning the years 2007 to 2017, the dataset includes 1716 instances characterized by 27 distinct features.

Dementia health matters: Influence of literacy, fears, and endorsements on dementia risk mitigation and screening among community-dwelling older adults.

Background: Up to one-third of dementia cases may be preventable, with evidence suggesting that modifying lifestyle and health behaviors can significantly lower the risk of developing dementia. However, motivating older adults to adopt and sustain these changes poses a considerable challenge, particularly when facing the specter of dementia.

Aim: To explore the interaction effect between dementia fear and dementia literacy on the perceived ability of community-dwelling older adults to reduce dementia risk and engage in dementia screening.

Effectiveness of Mindfulness-Based Interventions for Reducing Anxiety Among Women With Breast Cancer.

After receiving a diagnosis of breast cancer, patients may experience negative physical, mental, and psychological symptoms. When excessive and uncontrollable, anxiety can become a pathological disorder. Mindfulness-based interventions (MBIs) are psychological approaches that incorporate practices individuals can use to promote awareness, nonjudgmental acceptance, and present-moment focus.

Environmentally Friendly Nanoporous Polymeric Gels for Sustainable Wastewater Treatment.

Environmentally friendly nanoporous gels are tailor-designed and employed in the adsorption of toxic organic pollutants in wastewater. To ensure the maximum adsorption of the contaminant molecules by the gels, molecular modeling techniques were used to evaluate the binding affinity between the toxic organic contaminants such as methylene blue (MB) and Congo red (CR) and various biopolymers. To generate nanopores in the matrix of the polymeric gels, salt crystals were used as porogen.

Phytochemical profiling and fractionation of extract versus silver nanoparticle-modified extract: assessment of photoprotective, anti-hemolytic, antibacterial, and anti-inflammatory properties.

Introduction: This study investigates the synthesis of silver nanoparticles (Ag NPs) using Helianthemum lippii extract and evaluates their photoprotective, anti-hemolytic, antibacterial, and anti-inflammatory properties compared to various extract fractions, including total aqueous extract (AE), flavonoid monoglycosides (FMG), flavonoid diglycosides/triglycosides (FDG/FTG), tannins (TN), and anthocyanins (AC). Helianthemum lippii is rich in bioactive compounds such as caffeic acid, p-coumaric acid, and gallic acid, known for their therapeutic potential. This study aims to determine whether embedding these phytochemicals into Ag NPs enhances their biomedical applications compared to the natural extract fractions.

Influence of ethephon and soil treatments on the essential oil composition of sweet fennel and its biological activities.

The manipulation of cultivation conditions in addition to environmental changes is a key factor affecting the growth, secondary metabolites production, and the biological activity of the plant. Our study aims to evaluate the impact of foliar spray of ethephon, water stress, organic and inorganic fertilizers on the cytotoxic and antimicrobial activities of the fruit oil of Foeniculum vulgare, Miller, var. dulce and its vegetative growth and oil composition.

Unveiling the impact of pipe materials on water hammer in pressure pipelines: an experimental and numerical study.

Water hammer (WH) is a phenomenon characterized by the rapid opening or closing of valves or pumps in pipelines, resulting in a disruptive noise, intense vibrations, and potential damage to pipes, fittings, structures, and even human safety. While WH arresters are commonly employed to mitigate this issue in smaller plumbing systems, alternative solutions are required for larger applications like power plants. Researchers have proposed the utilization of pipe materials with a low modulus of elasticity in areas prone to WH events, as these materials possess the capability to absorb a significant portion of the resulting vibrations.

In-vivo and in-vitro assessment of curcumin loaded bile salt stabilized nanovesicles for oral delivery.

Background: Bile salts enriched nanovesicles (bilosomes) have been attention worthy in the past few years due to their distinctive effect on the enhancement of drug delivery through various physiological administration routes. Oral delivery of multifunctioning phytochemical curcumin has faced a lot of difficulties due to its scarce solubility and poor oral bioavailability.

Objective: The current investigation aimed to develop curcumin loaded bilosomes for improvement of oral curcumin bioavailability with maximum efficiency and safety.

Genetic Diversity and Drought Stress Tolerance of a Global Collection of Pearl Millet at Germination and Early Seedling Growth Stages.

Pearl millet {Pennisetum glaucum (L.) R. Br} is a C4 panicoid cereal millet crop grown in arid and semi-arid regions in Africa and Asia for food and fodder.