Secondary metabolites of Alternaria alternate appraisal of their SARS-CoV-2 inhibitory and anti-inflammatory potentials.

This study identifies the secondary metabolites from Alternaria alternate and evaluates their ACE-2: Spike RBD (SARS-CoV-2) inhibitory activity confirmed via immunoblotting in human lung microvascular endothelial cells. In addition, their in vitro anti-inflammatory potential was assessed using a cell-based assay in LPS-treated RAW 264.7 macrophage cells.

Natural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance.

Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements in cancer therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, and targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate cancer (PCa) is unfavorable since it is a perilous and lethal malignancy.

Hybrid multi-objective optimization of µ-synthesis robust controller for frequency regulation in isolated microgrids.

Frequency regulation in isolated microgrids is challenging due to system uncertainties and varying load demands. This study presents an optimal µ-synthesis robust control strategy that regulates microgrid frequency while enhancing system performance and stability-a proposed fixed-structure approach for selecting performance and robustness weights, informed by subsystem frequency analysis. The controller is optimized using multi-objective particle swarm optimization (MOPSO) and multi-objective genetic algorithm (MOGA) under inequality constraints, employing a Pareto front to identify optimal solutions.

Exploring the anticancer activities of Sulfur and magnesium oxide through integration of deep learning and fuzzy rough set analyses based on the features of Vidarabine alkaloid.

Drug discovery and development is a challenging and time-consuming process. Laboratory experiments conducted on Vidarabine showed IC 6.97 µg∕mL, 25.

Curcumin mimics of potential chemoprevention with NQO1 induction properties.

Chemoprevention is one of the accessible strategies for preventing, delaying or reversing cancer processing utilizing chemical intervention of carcinogenesis. NAD(P)H quinone oxidoreductase 1 (NQO1) is a xenobiotic metabolizing cytosolic enzyme/protein with important functional properties towards oxidation stress, supporting its ability in detoxification/chemoprotective role. A set of 3,5-diylidene-4-piperidones (as curcumin mimics) bearing alkyl sulfonyl group were synthesized with potential NQO1 induction properties.

Is CT pulmonary angiography overutilized in the evaluation of patients with suspected pulmonary embolism? A retrospective study.

Introduction: Despite the high mortality rate of acute untreated pulmonary embolism (PE) at 30%, diagnosing PE is challenging. While the prevalence of PE has decreased in recent years, the overuse of computed tomography pulmonary angiography (CTPA) remains a concern. The National Institute for Health and Care Excellence (NICE) provides guidelines using the Wells score for PE assessment.

Angiotensin-Converting Enzyme 2 (G8790A) Gene Polymorphism as a Risk Factor for COVID-19 in Egyptian Children and Adolescents.

Objective: Recently, angiotensin-converting enzyme 2 (ACE2) gene has emerged as a potential candidate gene for susceptibility to SARS-CoV-2 infection. We investigated whether ACE2 G8790A (rs2285666) polymorphism could be a genetic marker for susceptibility to COVID-19 and disease severity in Egyptian children and adolescents.

Methods: This was a prospective case-control study included 580 cases diagnosed with COVID-19, and 580 matched control children and adolescents.

Assessing the safety and effectiveness of endoscopic ultrasound for pediatric hepato-pancreatico-biliary disorders: a systematic review.

Background: Endoscopic ultrasound (US) has been established as a safe diagnostic tool for adults, but its use in children remains underexplored. The rising prevalence of pediatric hepato-pancreato-biliary disorders requires a closer examination of its utility. In this systematic review, we aimed to evaluate the efficacy, safety, and clinical impact of endoscopic US in the pediatric population, concentrating on its diagnostic accuracy and therapeutic applications.

Role of long non-coding RNAs and natural products in prostate cancer: insights into key signaling pathways.

Prostate cancer (PC) ranks among the most prevalent cancers in males. Recent studies have highlighted intricate connections between long non-coding RNAs (lncRNAs), natural products, and cellular signaling in PC development. LncRNAs, which are RNA transcripts without protein-coding function, influence cell growth, programmed cell death, metastasis, and resistance to treatments through pathways like PI3K/AKT, WNT/β-catenin, and androgen receptor signaling.

Empowering nurse leaders: readiness for AI integration and the perceived benefits of predictive analytics.

Introduction: Artificial Intelligence (AI) is increasingly being integrated into healthcare, particularly through predictive analytics that can enhance patient care and operational efficiency. Nursing leaders play a crucial role in the successful adoption of these technologies.

Aim: This study aims to assess the readiness of nursing leaders for AI integration and evaluate their perceptions of the benefits of AI-driven predictive analytics in healthcare.

New geographic information system based sustainability metric for isolated photovoltaic systems.

The integration of photovoltaic (PV) technologies is vital for achieving sustainable energy solutions in isolated systems. However, A critical challenge that remains is maintaining the sustainability of these systems under the fluctuating conditions of solar irradiance, which is key for isolated energy systems. This study hypothesizes that the sustainability of PV systems can be accurately assessed through a new metric that incorporates performance consistency, variability, and resilience, using real-time energy production data alongside GIS-based solar radiation models.

Anemia in pregnancy: a systematic review and meta-analysis of prevalence, determinants, and health impacts in Egypt.

Background: The WHO considers anemia in pregnancy a severe public health issue when prevalence surpasses 40%. In response, we conducted a systematic review and meta-analysis to examine anemia among pregnant women in Egypt, focusing on its prevalence, determinants, and associated complications.

Methods: We conducted a systematic literature search for studies published between January 1, 2010, and August 18, 2024, to identify studies from Egypt reporting on anemia in pregnant women, including its prevalence, associated determinants, and complications.

Morphometrics and First Ultrastructural Characterizations of Intra-Erythrocytic Stages of So-Called Haemogregarina damiettae Ramadan et al. (1996) With Special Reference to Its Cytopathological Effects on the Infected Erythrocytes.

The current study provides the first ultrastructural observations on the intraerythrocytic stages of so-called Haemogregarina damiettae and their cytopathological effects on the infected erythrocytes (IEs) in addition to the recording of new morphometric data. The intraerythrocytic stages are attributed to the immature forms or trophozoites (Ts), and mature gamonts (Gs). Ts are typically bowling-bottle shaped with nucleus (TN) occupying its globose part, while Gs are typically banana- shaped.

Blood cancer prediction model based on deep learning technique.

Blood cancer is among the critical health concerns among people around the world and normally emanates from genetic and environmental issues. Early detection becomes essential, as the rate of death associated with it is high, to ensure that the rate of treatment success is up, and mortality reduced. This paper focuses on improving blood cancer diagnosis using advanced deep learning techniques like ResNetRS50, RegNetX016, AlexNet, Convnext, EfficientNet, Inception_V3, Xception, and VGG19.

Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation.

This study was designed to assess the effect of brentuximab vedotin on several breast cancer cell lines in terms of promoting apoptosis and managing cancer progression. Additionally, the study investigated the potential of repurposing this drug for new therapeutic reasons, beyond its original indications. The study evaluates the cytotoxic effects of Brentuximab vedotin across five cell lines: normal human skin fibroblasts (HSF), three breast cancer cell lines (MCF-7, MDA-MB-231, and T-47D), and histiocytic lymphoma (U-937).

Enhanced bone cement for fixation of prosthetic joint utilizing nanoparticles.

Bone cement is commonly utilized to secure prosthetic joints in the body because of its robust fixation, stability, biocompatibility, and immediate load-bearing capability. However, issues such as loosening, leakage, and insufficient bioactivity can lead to its failure. Therefore, improving its mechanical, physical, and biological properties is crucial for enhancing its efficiency.

Epidemiological pattern of dengue fever in Afghanistan in the period 2021-22.

Dengue fever is considered as an emerging disease in Afghanistan. Since the first outbreak was reported in 2019, other outbreaks have been reported in the following years. The current study aims to describe the epidemiological features and clinical manifestations of suspected and confirmed cases of dengue fever detected by the National Disease Surveillance and Response (NDSR) Department of the Ministry of Public Health (MoPH) during 2021 and 2022 to prevent further spread and minimize its impact on the country's health system and on the limited number of health workers.

Harnessing miRNAs: A Novel Approach to Diagnosis and Treatment of Tuberculosis.

Mycobacterium tuberculosis (Mtb) complex, responsible for tuberculosis (TB) infection, continues to be a predominant global cause of mortality due to intricate host-pathogen interactions that affect disease progression. MicroRNAs (miRNAs), essential posttranscriptional regulators, have become pivotal modulators of these relationships. Recent findings indicate that miRNAs actively regulate immunological responses to Mtb complex by modulating autophagy, apoptosis, and immune cell activities.

Expert-Based Narrative Review on Compression UltraSonography (CUS) for Diagnosis and Follow-Up of Deep Venous Thrombosis (DVT).

Deep venous thrombosis (DVT) is a pathological condition that develops when a thrombus forms within the deep venous system. Typically, it involves the lower limbs and, less frequently, the upper extremities or other unusual districts such as cerebral or splanchnic veins. While leg DVT itself is rarely fatal and occasionally can lead to limb-threatening implications, its most fearsome complication, namely pulmonary embolism, is potentially fatal and significantly contributes to increased healthcare costs and impaired quality of life in affected patients and caregivers.

Minimum-Run Resolution IV Design for Optimized Bio Removal of Fe Using Aqueous Extract and Its Extract-Coated Silver Nanoparticles.

Biosorbents have demonstrated considerable potential for the remediation of metals in aqueous environments. An aqueous extract of L. (EiE) and its extract-coated silver nanoparticles have been prepared and employed for the removal of iron.

Survival of patients with non-viral hepatocellular carcinoma treated with trans-arterial chemoembolization: A multicenter cohort study.

Background And Study Aims: Few studies have considered patients treated with trans-arterial chemoembolization (TACE) for non-viral-induced hepatocellular carcinoma (HCC), with some reporting that those patients may have larger tumors, emphasizing the need for determination of the factors affecting survival in such patients. This work aims to study the characteristics and survival of patients with non-viral related HCC treated with TACE.

Patients And Methods: This is a multicenter observational study.

Cordycepin alleviates metabolic dysfunction-associated liver disease by restoring mitochondrial homeostasis and reducing oxidative stress via Parkin-mediated mitophagy.

The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) keeps rising with only a few drugs available. The present study aims to investigate the effects and mechanisms of cordycepin on MASLD. Male C57BL/6 mice were induced with a 90-day high-fat diet (HFD) and intraperitoneal administration with streptozotocin to establish MASLD murine model.

Rational Synthesis of Highly Fluorescent N, S Co-Doped Carbon Dots Using Biogenic Creatinine for Cu Analysis in Drinking Water.

Herein, highly fluorescent sulfur and nitrogen co-doped carbon dots (N, S-CDs) had been employed as a fluorescent probe to analyze Cu in drinking water. The biogenic creatinine is known to form a stable complex with Cu; hence, it was rationally selected as a bioinspired nitrogen substrate for the first time to enhance N, S-CDs selectivity towards Cu. Moreover, the literature was surveyed to guide the selection of sulfur and carbon sources to optimize N, S-CDs quantum yield (QY), so thiourea and disodium edetate are co-carbonized with biogenic creatinine at 270°C for 40 min and characterized using different techniques.

Finite element investigation for improving chest wall reconstruction process using ceramic and polymeric implants.

Car accidents, infections caused by bacteria or viruses, metastatic lesions, tumors, and malignancies are the most frequent causes of chest wall damage, leading to the removal of the affected area. After excision, artificial bone or synthetic materials are used in chest wall reconstruction to restore the skeletal structure of the chest. Chest implants have traditionally been made from metallic materials like titanium alloys due to their biocompatibility and durability.

Electrochemical study of anti-platelets tirofiban HCl in dosage form using nanomaterials modified sensors: developed and green assessed by eco-scale and complex-GAPI approach.

Tirofiban hydrochloride is used to inhibit platelet aggregation, which has a significant impact on the treatment of congestive heart failure the most common cause of death according to WHO. Therefore, its quantification in pharmaceutical dosage form is critical. In this work, an electrochemical method for the determination of tirofiban HCl in pharmaceutical dosage form was developed and validated.