2 results match your criteria: "Helmsley Electrophysiology Center (M.N.[Affiliation]"
Ablating Myocardium Using Nanosecond Pulsed Electric Fields: Preclinical Assessment of Feasibility, Safety, and Durability.
Circ Arrhythm Electrophysiol
July 2024
Helmsley Electrophysiology Center (M.N., K.W., I.K., V.Y.R., J.S.K.), Icahn School of Medicine at Mount Sinai, New York.
Article Synopsis
- This study examines a new catheter-based technique using nanosecond pulsed electric fields for cardiac ablation in pigs, focusing on its effectiveness at targeting both cell membranes and intracellular organelles.
- The research involved 25 pigs, assessing the impact of different ablation durations (low-dose and high-dose) on various heart sites, with evaluations conducted over various survival periods.
- Results showed that all targeted veins were successfully isolated, lesion depth was significant, and while there were some transient effects on the phrenic nerve and esophagus, most animals healed well over time with minimal long-term damage.
Preclinical Study of Pulsed Field Ablation of Difficult Ventricular Targets: Intracavitary Mobile Structures, Interventricular Septum, and Left Ventricular Free Wall.
Circ Arrhythm Electrophysiol
June 2024
Helmsley Electrophysiology Center (M.N., K.W., I.K., V.Y.R., J.S.K.).
Background: Endocardial catheter-based pulsed field ablation (PFA) of the ventricular myocardium is promising. However, little is known about PFA's ability to target intracavitary structures, epicardium, and ways to achieve transmural lesions across thick ventricular tissue.
Methods: A lattice-tip catheter was used to deliver biphasic monopolar PFA to swine ventricles under general anesthesia, with electroanatomical mapping, fluoroscopy and intracardiac echocardiography guidance.