7 results match your criteria: "Helios St. Johannes Hospital Duisburg[Affiliation]"

Background: Cancer immunotherapy has revolutionized melanoma treatment, but the high number of non-responders still emphasizes the need for improvement of therapy. One potential avenue for enhancing anti-tumor treatment is through the modulation of coagulation and platelet activity. Both have been found to play an important role in the tumor microenvironment, tumor growth and metastasis.

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Hydrochlorothiazide and increased risk of atypical fibroxanthoma and pleomorphic dermal sarcoma.

J Dtsch Dermatol Ges

April 2024

Department of Dermatology, Venereology, and Allergology, Helios St. Elisabeth Hospital Oberhausen, University of Witten-Herdecke, Oberhausen, Germany.

Article Synopsis
  • Hydrochlorothiazide (HCTZ) is linked to a higher risk of skin cancers such as Atypical fibroxanthoma (AFX) and pleomorphic sarcoma (PDS) compared to squamous cell carcinoma (SCC) and basal cell carcinoma (BCC).
  • A study analyzed data from 146 AFX/PDS patients and 438 SCC/BCC controls over a seven-year period, finding that HCTZ use was significantly more common among AFX/PDS patients (44.5% vs. 25.3%).
  • The findings suggest that HCTZ may be a risk factor for developing AFX/PDS, with diabetes mellitus also linked to an increased risk.
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The updated S2k guideline deals with the diagnosis and therapy of localized scleroderma (LoS). LoS represents a spectrum of sclerotic skin diseases in which, depending on the subtype and localisation, structures such as adipose tissue, muscles, joints, and bones may also be affected. Involvement of internal organs or progression to systemic sclerosis does not occur.

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