Risk factors for relaparotomy after a cesarean delivery: a case-control study.

Background: Relaparotomy following a cesarean delivery (CD) is an infrequent complication, with inconsistency regarding risk factors and indications for its occurrence. We therefore aimed to determine risk factors and indications for a relaparotomy following a CD at a single large tertiary center.

Methods: A retrospective case-control single-center study (2013-2023).

Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects.

Recombinant cytokines have limited anticancer efficacy mostly due to a narrow therapeutic window and systemic adverse effects. IL18 is an inflammasome-induced proinflammatory cytokine, which enhances T- and NK-cell activity and stimulates IFNγ production. The activity of IL18 is naturally blocked by a high-affinity endogenous binding protein (IL18BP).

To know or not to know: Effect of third-trimester sonographic fetal weight estimation on outcomes of large-for-gestational age neonates.

Objective: The aim of the present study was to evaluate the impact of late third-trimester sonographic estimation of large for gestational age fetuses on pregnancy management and selected fetal and maternal adverse outcomes.

Methods: A retrospective cohort study was conducted in a tertiary, university-affiliated medical center between 2015 and 2019. All singleton large-for-gestational-age neonates born during this period were included.

[ADJUSTING THE DAYS OF BLEEDING AND PURITY FOR A BRIDE BEFORE THE WEDDING. THE RELIGIOUS FEMALE GYNECOLOGISTS CONFERENCE WAS HELD ON THE 15TH OF JULY 2021 IN JERUSALEM, AND AN ONLINE UPDATE CONFERENCE WAS HELD ON NOVEMBER 5TH 2022].

ADJUSTING THE DAYS OF BLEEDING AND PURITY FOR A BRIDE BEFORE THE WEDDING. THE RELIGIOUS FEMALE GYNECOLOGISTS CONFERENCE WAS HELD ON THE 15TH OF JULY 2021 IN JERUSALEM, AND AN ONLINE UPDATE CONFERENCE WAS HELD ON NOVEMBER 5TH 2022.

Women's attitudes towards disclosure of genetic information in pregnancy with varying levels of penetrance.

Background: Chromosomal-microarray-analysis (CMA) may reveal susceptibility-loci (SL) of varied penetrance for autism-spectrum-disorder (ASD) and other neurodevelopmental conditions. Attitudes of women/parents to disclosure of SL during pregnancy are understudied.

Methods: A multiple-choice questionnaire was distributed to postpartum women.

A clinical predictive model for live birth in women of advanced age undergoing PGT cycles.

Purpose: The trend of delaying childbirth has resulted in a growing number of advanced-aged women who are opting for preimplantation genetic testing (PGT) to screen for monogenic diseases or structural chromosomal rearrangements (PGT-M and PGT-SR). This increase in demand necessitates the development of a clinical predictive model for live birth outcomes in these women. Therefore, the objective of this study is to construct a comprehensive predictive model that assesses the likelihood of achieving a successful live birth in advanced-aged women undergoing PGT-M and PGT-SR treatments.

Clinical significance of true umbilical cord knot: a propensity score matching study.

Objective: True umbilical cord knot (TUCK) is a rare finding that often leads to intensified surveillance and patient anxiety. This study sought to evaluate the incidence, risk factors, and obstetric and neonatal outcomes of TUCK.

Methods: A retrospective cohort study was conducted at a tertiary university medical center in 2007-2019.

THE EFFECT OF INTERNAL LIMITING MEMBRANE PEELING ON THE INNER RETINAL LAYERS IN PATIENTS WITHOUT MACULAR PATHOLOGIC CONDITION.

Background: To examine the effect of internal limiting membrane peeling on the inner retinal layers in patients without macular pathological condition.

Methods: A prospective nonrandomized trial of patients undergoing pars plana vitrectomy with internal limiting membrane peeling for pathologic condition outside the macula was performed. Optical coherence tomography including macular ganglion cell layer, inner plexiform layer, and peripapillary retinal nerve fiber layer imaging was performed before surgery, 1, 3, and 6 months postoperatively, and at the end of follow-up (ranges between 4 and 17 months).

Risk psychosocial factors associated with postpartum depression trajectories from birth to six months.

Purpose: The purpose of this study was to assess the trajectory of women's depressive symptoms during the first six months postpartum, identify risk factors (sociodemographic, obstetric and personality) associated with classes, and examine associations between classes and postpartum PTSD at two months and bonding at six months.

Methods: The final sample included 212 women who gave birth in the maternity wards of a large tertiary health center that were approached at 1-3 days, two months, and six months postpartum and completed a demographic questionnaire and measures of neuroticism (BFI) and postpartum depression (EPDS), postpartum PTSD (City Birth Trauma Scale) and bonding (PBQ). Obstetric data were taken from the medical files.

Long-term risk of adnexal operation after vaginal hysterectomy for pelvic organs prolapse repair.

Objective: To determine if women who undergo vaginal hysterectomy for pelvic floor prolapse repair without concomitant opportunistic bilateral salpingo-oophorectomy are at increased risk of further complications related to the remaining adnexa later in life.

Study Design: The database of a tertiary university medical center was searched for all women who underwent vaginal hysterectomy as part of the treatment for pelvic organ prolapse, without opportunistic adnexectomy, from 2006 to 2015 to provide adequate time for long-term evaluation. Demographic and clinical data including surgeries performed during the long-term follow-up were collected from all medical insurer electronic medical records.

Is Oxytocin Administration During Childbirth Associated With Increased Risk for Postpartum Posttraumatic Stress Symptoms?: A Preliminary Investigation.

Introduction: Synthetic oxytocin is one of the most regularly administered medications to facilitate labor induction and augmentation. The present study examined the associations between oxytocin administration during childbirth and postpartum posttraumatic stress symptoms (PTSS).

Materials And Methods: In a multicenter longitudinal study, women completed questionnaires during pregnancy and at 2 months postpartum ( N = 386).

Predicting adverse perinatal outcomes among gestational diabetes complicated pregnancies using neural network algorithm.

Objective: The primary aim of this study is to utilize a neural network model to predict adverse neonatal outcomes in pregnancies complicated by gestational diabetes (GDM).

Design: Our model, based on XGBoost, was implemented using Python 3.6 with the Keras framework built on TensorFlow by Google.

Outcome of subsequent pregnancies in women with prior uterine rupture.

Objective: To report maternal and neonatal outcomes of subsequent pregnancies in a series of women with a prior uterine rupture.

Methods: The records of all 103,542 deliveries (22,286 by cesarean section) performed in a single tertiary medical center from 2009 to 2021 were reviewed. Women with a prior uterine rupture, defined as a separation of the entire thickness of the uterine wall, with extrusion of fetal parts and intra-amniotic contents into the peritoneal cavity documented in the operative report of the previous cesarean delivery or laparotomy, were identified for inclusion in the study.

Congenital diaphragmatic hernia: quality improvement using a maximal lung protection strategy and early surgery-improved survival.

Unlabelled: To evaluate the effectiveness of a novel protocol, adopted in our institution, as a quality improvement project for congenital diaphragmatic hernia (CDH). A maximal lung protection (MLP) protocol was implemented in 2019. This strategy included immediate use of high-frequency oscillatory ventilation (HFOV) after birth, during the stay at the Neonatal Intensive Care Unit (NICU), and during surgical repair.

Association between Hidradenitis Suppurativa and Abnormalities in Semen Parameters and Sexual Function: A Pilot Study.

Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting patients of reproductive age. Although HS shares risk factors with male infertility, only 1 epidemiological study has evaluated this association. To further evaluate this potential association, findings on semen and hormonal analysis, testicular ultrasound, and the International Index of Erectile Function (IIEF-15) were compared between 28 men attending a tertiary HS clinic during the period April 2019 to April 2021, and 44 healthy controls, spouses of infertile women undergoing semen evaluation before in vitro fertilization.

[DECISION-MAKING FACILITATION MODEL IN UNCERTAINTY - GENETIC COUNSELING FOR PATHOGENIC AMNIOCENTESIS CMA RESULTS].

Two approaches exist in clinical genetics - an approach that advocates non-directive genetic counseling and an approach of assisted patient decision-making. Genetic counseling for patients in the era of technological progress, a significant and rapid increase in existing knowledge and the availability of genetic information presents patients with difficult dilemmas under emotional burden with insufficient tools to support decision-making. This article presents a decision-making facilitation model for geneticists, using an example case of genetic counseling for a pathogenic chromosomal microarray result from fetal DNA after amniocentesis, with an unknown fetal clinical significance.

Risk of thrombocytopenia in neonates of thrombocytopenic mothers.

Objective: Maternal thrombocytopenia during pregnancy may occur due to several possible etiologies, with potential neonatal impact. The aim of the present study was to investigate whether there is a correlation between maternal and neonatal platelet count among women with thrombocytopenia during pregnancy.

Methods: A cross-sectional retrospective study (2012-2019) was conducted at a tertiary medical center.

Perinatal outcomes following uterine rupture during a trial of labor after cesarean: A 12-year single-center experience.

Objective: To determine perinatal outcomes following uterine rupture during a trial of labor after one previous cesarean delivery (CD) at term.

Methods: A retrospective single-center study examining perinatal outcomes in women with term singleton pregnancies with one prior CD, who underwent a trial of labor after cesarean (TOLAC) and were diagnosed with uterine rupture, between 2011 and 2022. The primary outcome was a composite maternal outcome, and the secondary outcome was a composite neonatal outcome.

Social support as a differential moderator of the association between optimism, birth satisfaction, and postpartum acute stress symptoms of fathers and mothers.

Objective: Childbirth can be a stressful event that leads to the development of acute stress. However, little is known about postpartum acute stress among mothers and even less among fathers. The current study aims to expand the understanding of postpartum acute stress symptoms by examining associations with dispositional optimism, subjective birth satisfaction, and social support in a moderated-mediation model.

Fetal surgery using fetoscopic endoluminal tracheal occlusion for severe congenital diaphragmatic hernia: a single-center experience.

Purpose: To provide a comprehensive report of the experience gained in the prenatal treatment of congenital diaphragmatic hernia (CDH) using fetoscopic endoluminal tracheal occlusion (FETO) following its implementation at a newly established specialized fetal medicine center.

Methods: Mothers of fetuses with severe CDH were offered prenatal treatment by FETO.

Results: Between 2018 and 2021, 16 cases of severe CDH underwent FETO.

Hebrew validation of the postpartum bonding questionnaire: a study of mothers and fathers.

Objective: The Postpartum Bonding Questionnaire (PBQ) is a self-report questionnaire designed to screen disorders of the mother-infant relationship. The PBQ was adapted to several countries, though there is no agreement on the accepted number of items and factors. This study aimed to assess the validity and reliability of the Hebrew version for both mothers and fathers.