1 results match your criteria: "Heidelberg University and the German Cancer Research Center (DKFZ-ZMBH Alliance) Heidelberg[Affiliation]"
The Rac1 regulator ELMO1 controls vascular morphogenesis in zebrafish.
Circ Res
July 2010
Center for Biomedicine and Medical Technology Mannheim, Research Division Vascular Biology of the Medical Faculty Mannheim, Heidelberg University and the German Cancer Research Center (DKFZ-ZMBH Alliance) Heidelberg, Mannheim, Germany.
Article Synopsis
- Angiogenesis is regulated by the Rac1 GTPase through the ELMO1/DOCK180 complex, which acts as a guanine nucleotide exchange factor for Rac1 during cell migration.
- In zebrafish studies, silencing elmo1 significantly disrupted vascular development, affecting various vessels and the thoracic duct.
- Netrin-1 and its receptor Unc5B were found to activate the ELMO1/DOCK180 complex, leading to Rac1 activation and proper vessel formation.