2 results match your criteria: "Heidelberg University Childrens Hospital[Affiliation]"
Expression of immune checkpoint molecules on adult and neonatal T-cells.
Immunol Res
April 2023
Department of Neonatology, Tübingen University Children's Hospital, Tübingen, Germany.
Article Synopsis
- Neonates are more susceptible to serious bacterial infections and post-inflammatory diseases like bronchopulmonary dysplasia (BPD) and periventricular leukomalacia (PVL) compared to adults, potentially due to an inability to effectively manage inflammation.
- The study investigates the behavior of neonatal T-cells, revealing that they have a higher proliferation rate and increased activation markers compared to adult T-cells when stimulated, but show lower levels of immune-checkpoint molecules (ICMs), particularly PD-L1.
- This reduced expression of PD-L1 in neonatal T-cells, especially after exposure to pathogens like Group B Streptococcus, may contribute to their heightened risk of developing post-inflammatory conditions.
Re: "Do Not Act Fast and Furious".
Pediatr Infect Dis J
February 2022
Department of Neonatology, Heidelberg University Childrens Hospital, Heidelberg, Germany.