2 results match your criteria: "Heidelberg Institute of Radiation Oncology and National Center for Radiation Oncology[Affiliation]"
Biosensor Cell-Fit-HD for correlation of single-cell fate and microscale energy deposition in complex ion beams.
STAR Protoc
December 2022
Division of Molecular and Translational Radiation Oncology and Clinical Cooperation Unit Translational Radiation Oncology, German Cancer Research Center (DKFZ) and Heidelberg University Hospital, 69120 Heidelberg, Germany; National Center for Tumor Diseases, German Cancer Consortium, Heidelberg Institute of Radiation Oncology and National Center for Radiation Oncology, 69120 Heidelberg, Germany. Electronic address:
We present a protocol for the biosensor Cell-Fit-HD. It enables long-term monitoring and correlation of single-cell fate with subcellular-deposited energy of ionizing radiation. Cell fate tracking using widefield time-lapse microscopy is uncoupled in time from confocal ion track imaging.
View Article and Find Full Text PDFBiosensor for deconvolution of individual cell fate in response to ion beam irradiation.
Cell Rep Methods
February 2022
Division of Molecular and Translational Radiation Oncology and Clinical Cooperation Unit Translational Radiation Oncology, German Cancer Research Center (DKFZ) and Heidelberg University Hospital, 69120 Heidelberg, Germany.
Article Synopsis
- - Scientists usually use a test called a clonogenic survival assay to see how radiation affects cells, but it doesn’t account for differences between individual cells and how radiation hits them.
- - Researchers created a new tool called "Cell-Fit-HD" that helps study how each cell reacts to radiation by looking at it closely with a microscope.
- - This new method can help learn more about how radiation works on tiny levels, which might improve treatments and studies related to radiation in medicine.