Metabolic reprogramming and astrocytes polarization following ischemic stroke.

Astrocytes are critical for maintaining neuronal activity. Activation of astrocytes, occurs within minutes from ischemic stroke onset due to ischemic causes and subsequent inflammatory damage. Activated astrocytes, also known as reactive astrocytes, are divided into two different phenotypes: A1 (pro-inflammatory) and A2 (anti-inflammatory) astrocytes.

Application of lanthanum-modified silk fibroin/polyvinyl alcohol film for highly selective defluoridation in brick tea infusion.

To mitigate the risk associated with water-soluble fluoride in tea and to have less influence on the contents of tea infusion, a highly selective lanthanum modified silk fibroin (SF) and polyvinyl alcohol (PVA) composite film (SF/PVA-La) was prepared to remove fluoride from brick tea infusion. Notably, SF/PVA-La could remove about 48 % of the fluoride from in brick tea infusion within 30 min. Importantly, the reduction in total tea polyphenols in brick tea did not exceed 10 %, and the reduction in caffeine was only 0.

Anti-Inflammatory Effects of Hydrogen Sulfide in Axes Between Gut and Other Organs.

Hydrogen sulfide (HS), a ubiquitous small gaseous signaling molecule, plays a critical role in various diseases, such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), ischemic stroke, and myocardial infarction (MI) reducing inflammation, inhibiting oxidative stress, and cell apoptosis. Uncontrolled inflammation is closely related to pathological process of ischemic stroke, RA, MI, and IBD. Solid evidence has revealed the axes between gut and other organs like joint, brain, and heart, and indicated that HS-mediated anti-inflammatory effect against IBD, RA, MI, and ischemic stroke might be related to regulating the functions of axes between gut and other organs.

Effect analysis of repeated transcranial magnetic stimulation combined with fluoxetine in the treatment of first-episode adolescent depression.

Objectives: This study aims to evaluate the efficacy of repeated transcranial magnetic stimulation (rTMS) combined with fluoxetine in enhancing the early antidepressant response in first-episode adolescent depression cases, providing insights for patient diagnosis and treatment.

Methods: One hundred and thirty-five adolescents experiencing their first depressive episode were randomly assigned to either a sham group treated with fluoxetine or to low or high repetitive transcranial magnetic stimulation (rTMS) groups receiving both rTMS and fluoxetine. Therapeutic effects were assessed by comparing changes in Hamilton Depression Scale (HAMD-17) scores, cognitive function scores from the Wisconsin Card Sorting Test (WCST), and Clinical Global Impression-improvement (CGI-I) scores, along with recording adverse reactions.

The Roles of RhoA/ROCK/NF-κB Pathway in Microglia Polarization Following Ischemic Stroke.

Ischemic stroke is the leading cause of death and disability worldwide. Nevertheless, there still lacks the effective therapies for ischemic stroke. Microglia are resident macrophages of the central nervous system (CNS) and can initiate immune responses and monitor the microenvironment.

Neuroinflammation and Post-Stroke Depression: Focus on the Microglia and Astrocytes.

Post-stroke depression (PSD), a frequent and disabling complication of stroke, has a strong impact on almost thirty percent of stroke survivors. The pathogenesis of PSD is not completely clear so far. Neuroinflammation following stroke is one of underlying mechanisms that involves in the pathophysiology of PSD and plays an important function in the development of depression and is regarded as a sign of depression.

Autonomous motivation, social support, and physical activity in school children: moderating effects of school-based rope skipping sports participation.

Purpose: Recent studies have shown that physical activity (PA) levels are low among children and adolescents globally. In order to reverse this trend, PA interventions are increasingly favoured. The school setting is the ideal place to address the issues that many children face.

Crosstalk Among Glial Cells in the Blood-Brain Barrier Injury After Ischemic Stroke.

Blood-brain barrier (BBB) is comprised of brain microvascular endothelial cells (ECs), astrocytes, perivascular microglia, pericytes, neuronal processes, and the basal lamina. As a complex and dynamic interface between the blood and the central nervous system (CNS), BBB is responsible for transporting nutrients essential for the normal metabolism of brain cells and hinders many toxic compounds entering into the CNS. The loss of BBB integrity following stroke induces tissue damage, inflammation, edema, and neural dysfunction.

Weighted residual network for SAR automatic target recognition with data augmentation.

Introduction: Decades of research have been dedicated to overcoming the obstacles inherent in synthetic aperture radar (SAR) automatic target recognition (ATR). The rise of deep learning technologies has brought a wave of new possibilities, demonstrating significant progress in the field. However, challenges like the susceptibility of SAR images to noise, the requirement for large-scale training datasets, and the often protracted duration of model training still persist.

Flavonoids and ischemic stroke-induced neuroinflammation: Focus on the glial cells.

Ischemic stroke is one of the most cases worldwide, with high rate of morbidity and mortality. In the pathological process of ischemic stroke, neuroinflammation is an essential process that defines the functional prognosis. After stroke onset, microglia, astrocytes and the infiltrating immune cells contribute to a complicated neuroinflammation cascade and play the complicated roles in the pathophysiological variations of ischemic stroke.

Metabolite profiling and identification of enzymes responsible for the metabolism of hirsutine, a major alkaloid from .

The metabolism of hirsutine was determined using liver microsomes and human recombinant cytochrome P450 enzymes. Under the current conditions, a total of 14 phase I metabolites were tentatively identified.Ketoconazole showed significant inhibitory effect on the metabolism of hirsutine.

Zhisou powder displays therapeutic effect on chronic bronchitis through inhibiting PI3K/Akt/HIF-1α/VEGFA signaling pathway and reprograming metabolic pathway of arachidonic acid.

Ethnopharmacological Relevance: Zhisou Powder (ZP), one of the most common prescriptions in traditional Chinese medicine, has been widely used in the treatment of acute or chronic bronchitis and chronic cough. The ZP was composed of Ziwan (Aster tataricus L. f.

The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation.

It is widely known that ischemic stroke is the prominent cause of death and disability. To date, neuroinflammation following ischemic stroke represents a complex event, which is an essential process and affects the prognosis of both experimental stroke animals and stroke patients. Intense neuroinflammation occurring during the acute phase of stroke contributes to neuronal injury, BBB breakdown, and worse neurological outcomes.

HS-RhoA/ROCK Pathway and Glial Cells in Axonal Remyelination After Ischemic Stroke.

Ischemic stroke is one of the main reasons of disability and death. Stroke-induced functional deficits are mainly due to the secondary degeneration of the white matter characterized by axonal demyelination and injury of axon-glial integrity. Enhancement of the axonal regeneration and remyelination could promote the neural functional recovery.

Copper Phosphide Nanowires as High-Performance Catalysts for Urea-Assisted Hydrogen Evolution in Alkaline Medium.

Water electrolysis represented a promising avenue for the large-scale production of high-purity hydrogen. However, the high overpotential and sluggish reaction rates associated with the anodic oxygen evolution reaction (OER) posed significant obstacles to efficient water splitting. To tackle these challenges, the urea oxidation reaction (UOR) emerged as a more favorable thermodynamic alternative to OER, offering both the energy-efficient hydrogen evolution reaction (HER) and the potential for the treating of urea-rich wastewater.

The spatiotemporal profile of and functional identification of genes under exogenous MeJA using comparative transcriptomics and genomics.

Introduction: Alkaloids are one of the main medicinal components of species. alkaloids are mainly composed of terpene alkaloids. Jasmonic acid (JA) induce the biosynthesis of such alkaloids, mainly by enhancing the expression of JA-responsive genes to increase plant resistance and increase the content of alkaloids.

Sodium New Houttuyfonate Effectively Improves Phagocytosis and Inhibits the Excessive Release of Inflammatory Factors by Repressing TLR4/NF-Кb Pathway in Macrophages.

Background: Sodium new houttuyfonate (SNH) is an adduct of houttuyfonate, which is the main component of the common Chinese medicinal plant . SNH has been widely used in antibacterial and anti-inflammatory treatments in clinics. However, the exact antimicrobial mechanism of SNH is still unclear, despite its mild direct antimicrobial activity Objectives: The aim of this study is to investigate the effect and possible mechanism of SNH on macrophages against bacteria .

Facilitating interface charge transfer via constructing NiO/NiCoO heterostructure for oxygen evolution reaction under alkaline conditions.

Designing high-activity electrocatalysts to enhance the slow multielectron-transfer process of the oxygen evolution reaction (OER) is of great importance for hydrogen generation. Here, we employ hydrothermal and subsequent heat-treatment strategies to acquire nanoarrays-structured NiO/NiCoO heterojunction anchored Ni foam (NiO/NiCoO/NF) as efficient materials for catalyzing the OER in an alkaline electrolyte. Density functional theory (DFT) results demonstrate that NiO/NiCoO/NF exhibits a smaller overpotential than those of single NiO/NF and NiCoO/NF owing to interface-triggered numerous interface charge transfer.

Robust FeCoP nanoparticles grown on a rGO-coated Ni foam as an efficient oxygen evolution catalyst for excellent alkaline and seawater electrolysis.

Electrochemical water splitting is a potential green hydrogen energy generation technique. With the shortage of fresh water, abundant seawater resources should be developed as the main raw material for water electrolysis. However, since the precipitation reaction of chloride ions in seawater will compete with the oxygen evolution reaction (OER) and corrode the catalyst, seawater electrolysis is restricted by the decrease in activity, low stability, and selectivity.

MOF-derived nitrogen-doped porous carbon nanofibers with interconnected channels for high-stability Li/Na battery anodes.

Heteroatom-doped porous carbon materials have been widely used as anode materials for Li-ion and Na-ion batteries, however, improving the specific capacity and long-term cycling stability of ion batteries remains a major challenge. Here, we report a facile based metal-organic framework (MOFs) strategy to synthesize nitrogen-doped porous carbon nanofibers (NCNFs) with a large number of interconnected channels that can increase the contact area between the material and the electrolyte, shorten the diffusion distance between Li/Na and the electrolyte, and relieve the volume expansion of the electrode material during cycling; the doping of nitrogen atoms can improve the conductivity and increase the active sites of the carbon material, can also affect the microstructure and electron distribution of the electrode material, thereby improving the electrochemical performance of the material. As expected, the obtained NCNFs-800 exhibited excellent electrochemical performance with high reversible capacity (for Li battery anodes: 1237 mA h g at 100 mA g after 200 cycles, for Na battery anodes: 323 mA h g at 100 mA g after 150 cycles) and long-term cycling stability (for Li battery anodes: 635 mA h g at 2 A g after 5000 cycles, for Na battery anodes: 194 mA h g at 2 A g after 5000 cycles).

A novel CDK8 inhibitor with poly-substituted pyridine core: Discovery and anti-inflammatory activity evaluation in vivo.

As an ideal anti-inflammatory target, cyclin-dependent kinase 8 (CDK8) has gradually attracted the attention of researchers. CDK8 inhibition up-regulates Interleukin-10 (IL-10) expression by enhancing the transcriptional activity of activator protein-1 (AP-1), and augmenting IL-10 abundance is a viable strategy for the treatment of inflammatory bowel disease (IBD). In this research, through structure-based drug design and dominant fragment hybridization, a series of poly-substituted pyridine derivatives were designed and synthesized as CDK8 inhibitors.

Heterogeneous Ni-MoN nanosheet-assembled microspheres for urea-assisted hydrogen production.

Electrocatalytic water splitting is a promising technology for sustainable hydrogen (H) production; however, it is restricted by the kinetically sluggish anodic oxygen evolution reaction (OER). Replacing OER with urea oxidation reaction (UOR) with low thermodynamic potential can simultaneously improve the energy efficiency of H production and purify urea-containing wastewater. Here we report a facile assembly-calcination two-step method to synthesize heterogeneous Ni-MoN nanosheet-assembled microspheres (Ni-MoN NAMs).

HS-mediated inhibition of RhoA/ROCK pathway and noncoding RNAs in ischemic stroke.

Ischemic stroke is one of major causes of disability. In the pathological process of ischemic stroke, the up-regulation of Ras homolog gene family, member A (RhoA) and its downstream effector, Ras homolog gene family (Rho)-associated coiled coil-containing kinase (ROCK), contribute to the neuroinflammation, blood-brain barrier (BBB) dysfunction, neuronal apoptosis, axon growth inhibition and astrogliosis. Accumulating evidences have revealed that hydrogen sulphide (HS) could reduce brain injury in animal model of ischemic stroke via inhibiting the RhoA/ROCK pathway.

Probiotic Cocktail Alleviates Intestinal Inflammation Through Improving Gut Microbiota and Metabolites in Colitis Mice.

The modulation of the gut microbiome has been widely suggested as a promising therapeutic strategy for inflammatory bowel disease (IBD). Here, we established a novel probiotic cocktail to investigate its therapeutic role in acute colitis mice. During dextran sulfate sodium (DSS)-induced colitis, the mice were treated with the probiotic cocktail, fecal microbiota transplantation (FMT) from a healthy mice donor, or 5-aminosalicylic acid (5-ASA), respectively.