Manometric findings in children with eosinophilic esophagitis and persistent post-remission dysphagia.

Objectives: Dysphagia is a frequent symptom of active eosinophilic esophagitis (EoE), but at times it persists despite attaining histologic healing and lack of fibro-stenotic changes. We aimed to describe the manometric findings in this subset of patients.

Methods: A retrospective review of charts between 2013 and 2023 at a tertiary pediatric gastroenterology center, treating roughly 1500 EoE patients per year.

Environmental factors influencing red knot () departure times of relocation flights within the non-breeding period.

Deciding when to depart on long-distance, sometimes global, movements can be especially important for flying species. Adverse weather conditions can affect energetic flight costs and navigational ability. While departure timings and conditions have been well-studied for migratory flights to and from the breeding range, few studies have focussed on flights within the non-breeding season.

Revisiting the species list of freshwater fish in Israel based on DNA barcoding.

Israel's region forms a continental bridge; hence, the freshwater fish fauna in Israel consists of unique populations of species that originated from Africa, Asia, or Europe and are often endemic or at the edge of their distribution range. Worldwide, fish biodiversity suffers significantly from pressures and disturbances of freshwater habitats, especially in arid regions, such as in parts of Israel. Biodiversity conservation requires efficient tools for monitoring changes in populations.

SNG100, a novel topical treatment for moderate atopic dermatitis, in patients aged 6 years or older: A randomised, double-blind, active-controlled trial.

Background: Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. It is associated with significant itch and impaired quality of life. Systemic treatments are efficient but associated with side effects.

Life-threatening bronchospasm induced by an angiotensin-converting enzyme inhibitor in a chronically ventilated patient: Diagnostic pitfalls and literature review.

Cough- and asthma-like symptoms are common adverse reactions to angiotensin-converting enzyme inhibitors (ACEi). However, attributing these symptoms to the use of ACEi might be masked by clinical confounders. We report a 68-year-old female residing in a long-term acute-care facility for patients requiring prolonged invasive mechanical ventilation treated for years with ACEi.

Single- Versus Dual-Chamber Implantable Cardioverter-Defibrillator for Primary Prevention of Sudden Cardiac Death in the United States.

Background Routine addition of an atrial lead during an implantable cardioverter-defibrillator (ICD) implantation for primary prevention of sudden cardiac death, in patients without pacing indications, was not shown beneficial in contemporary studies. We aimed to investigate the use and safety of single- versus dual-chamber ICD implantations in these patients. Methods and Results Using the National Inpatient Sample database, we identified patients with no pacing indications who underwent primary-prevention ICD implantation in the United States between 2015 and 2019.

Fear of predators alters herbivore regulation of soil microbial community function.

Fear of predation can affect important ecosystem processes by altering the prey traits expression that, in turn, regulates the quantity and quality of nutritional inputs to soil. Here, we aimed to assist in bridging a knowledge gap in this cascading chain of events by exploring how risk of spider predation may affect grasshopper prey performances, and the activity of various microbial extracellular enzymes in the soil. Using a mesocosms field-experiment, we found that grasshoppers threatened by spider predation ate less, grew slower, and had a higher body carbon to nitrogen ratio.

Titanium complexes affect biofilm formation.

Biofilms are surface or interface-associated communities of bacterial cells, embedded in a self-secreted extracellular matrix (ECM). Cells in biofilms are 100-1000 times more resistant to antibiotic treatment relative to planktonic cells due to various reasons, including the ECM acting as a diffusion barrier to antibiotic molecules, the presence of persister cells that divide slowly and are less susceptible to cell-wall targeting drugs, and the activation of efflux pumps in response to antibiotic stress. In this study we tested the effect of two titanium(iv) complexes that have been previously reported as potent and non-toxic anticancer chemotherapeutic agents on cells in culture and in biofilm forming conditions.

Archaeomagnetism in the Levant and Mesopotamia Reveals the Largest Changes in the Geomagnetic Field.

Our understanding of geomagnetic field intensity prior to the era of direct instrumental measurements relies on paleointensity analysis of rocks and archaeological materials that serve as magnetic recorders. Only in rare cases are absolute paleointensity data sets continuous over millennial timescales, in sub-centennial resolution, and directly dated using radiocarbon. As a result, fundamental properties of the geomagnetic field, such as its maximum intensity and rate of change have remained a subject of lively discussion.

I hate you when I am anxious: Anxiety during the COVID-19 epidemic and ideological hostility.

Most previous studies that examined the effect of anxiety on hostility towards a distinct group have focused on cases in which we hate those we are afraid of. The current study, on the other hand, examines the relationship between anxiety in one domain and hostility towards a distinct group that is not the source of that anxiety. We focus here on symptoms of anxiety during the COVID-19 pandemic, which have become increasingly frequent, and show that the implications of such mental difficulties are far-reaching, posing a threat to relationships between ideological groups.

The Late Middle Pleistocene mammalian fauna of Oumm Qatafa Cave, Judean Desert: taxonomy, taphonomy and palaeoenvironment.

The Middle Pleistocene archaeological record of the southern Levant has proven key to understanding human evolution and intercontinental faunal biogeography. Knowledge of archaeological sites of that period in the southern Levant is biased, with most Middle Pleistocene localities in the Mediterranean areas in the north, despite the mosaic of environments that mark the entire region. A key Middle Pleistocene location in the Judean Desert - on the eastern margin of the Mediterranean zone - is the site of Oumm Qatafa, excavated in the early 1900s, which yielded a faunal collection spanning an estimated time period of 600-200 kya.

Planetary, inertia-gravity and Kelvin waves on the -plane and -plane in the presence of a uniform zonal flow.

A linear wave theory of the Rotating Shallow-Water Equations (RSWE) is developed in a channel on the midlatitude -plane or -plane in the presence of a uniform mean zonal flow that is balanced geostrophically by a meridional gradient of the fluid surface height. Here we show that this surface height gradient is a potential vorticity (PV) source that generates Rossby waves even on the -plane similar to the generation of these waves by PV sources such as the -effect, shear of the mean flow and bottom topography. Numerical solutions of the RSWE show that the resulting Rossby, Poincaré and "Kelvin-like" waves differ from their counterparts without mean flow in both their phase speeds and meridional structures.

Anthropogenic Aerosols Modulated 20th-Century Sahel Rainfall Variability Via Their Impacts on North Atlantic Sea Surface Temperature.

The Sahel rainfall has a close teleconnection with North Atlantic sea surface temperature (NASST) variability, which has separately been shown to be affected by aerosols. Therefore, changes in regional aerosols emission could potentially drive multidecadal Sahel rainfall variability. Here we combine ensembles of state-of-the-art global climate models (the CESM and CanESM large ensemble simulations and CMIP6 models) with observational data sets to demonstrate that anthropogenic aerosols have significantly impacted 20th-century detrended Sahel rainfall multidecadal variability through modifying NASST.

Use of artificial intelligence as a didactic tool to improve ejection fraction assessment in the emergency department: A randomized controlled pilot study.

Objectives: Incorporating artificial intelligence (AI) into echocardiography operated by clinicians working in the emergency department to accurately assess left-ventricular ejection fraction (LVEF) may lead to better diagnostic decisions. This randomized controlled pilot study aimed to evaluate AI use as a didactic tool to improve noncardiologist clinicians' assessment of LVEF from the apical 4-chamber (A4ch) view.

Methods: This prospective randomized controlled pilot study tested the feasibility and acceptability of the incorporation of AI as a didactic tool by comparing the ability of 16 clinicians who work in the emergency department to assess LVEF before and after the introduction of an AI-based ultrasound application.

Introduction of quorum sensing elements into bacterial bioreporter circuits enhances explosives' detection capabilities.

A possible solution for the standoff detection of buried landmines is based on the use of microbial bioreporters, genetically engineered to emit a remotely detectable optical signal in response to trace amounts of explosives' signature chemicals, mostly 2,4-dinitrotoluene (DNT). Previously developed DNT sensor strains were based on the fusion of a DNT-inducible gene promoter to a reporting element, either a fluorescent protein gene or a bacterial bioluminescence gene cassette. In the present study, a different approach was used: the DNT-inducible promoter activates, in , the quorum-sensing and genes of .

Peer feedback decreases impulsive choice in adolescents with and without attention-deficit/hyperactivity disorder.

Background: Impulsivity is a core feature of attention-deficit/hyperactivity disorder (ADHD). Previous work using the delay discounting task to assess impulsivity reveals that adolescents with ADHD tend to prefer a smaller-immediate reward over a larger-delayed reward, and this relates to problematic choices in daily life. To gain a better understanding of daily decision-making in adolescence, it is important to examine the social context, as peers have a major influence on decisions.

Forcing Convection to Aggregate Using Diabatic Heating Perturbations.

Tropical deep convection can aggregate into large clusters, which can have impacts on the local humidity and precipitation. Sea surface temperature (SST) gradients have been shown to organize convection, yet there has been little work done to investigate the impact of diabatic heating perturbations in the atmosphere on the aggregation of convection. Here we investigate how anomalous diabatic heating of the atmospheric column, through an idealized aerosol plume, affects the existence and mechanisms of convective aggregation in non-rotating, global radiative-convective equilibrium simulations.

Normative data for ages 18-45 for ocular motor and vestibular testing using eye tracking.

Objective: Eye tracking technology has been employed in assessing ocular motor and vestibular function following vestibular and neurologic conditions, including traumatic brain injury (TBI). Assessments include tests that provide visual and motion (rotation) stimuli while recording horizontal, vertical, and torsional eye movements. While some of these tests have shown diagnostic promise in previous studies, their use in clinical practice is limited by the lack of normative data.

An analysis of social determinants of health and structural competency training in global emergency medicine fellowship programs in the United States.

Background: Clinicians must be aware of the structural forces that affect their patients to appropriately address their unique health care needs. This study aimed to assess the participation of global emergency medicine (GEM) fellowship programs in formal social determinants of health (SDH) and structural competency (SC) training to evaluate the existence and procedures of such programs.

Methods: A cross-sectional study conducted with a short, online survey with questions regarding the presence of curriculum focused on SDH, SC, educational metrics, and the desire for further formal training in this domain was sent to all 25 GEM fellowship directors through the Global Emergency Medicine Fellowship Consortium (GEMFC) email listserv.

Diffuse pulmonary calcifications: A case series and review of literature.

Pulmonary calcifications are usually incidental asymptomatic findings discovered on x-rays or computed tomography scans that can be easily overlooked, and their significance undermined, especially in a seemingly asymptomatic person. Calcifications can be a marker of chronicity or disease severity, and thus have diagnostic value. Rarely, calcification can be the direct cause of morbidity.

Cognitive and behavioral radicalization: A systematic review of the putative risk and protective factors.

Background: Two of the most central questions in radicalization research are, (1) why do some individuals radicalize when most of those from the same groups or exposed to similar conditions do not? and (2) why do radicalized individuals turn to radical violence while the majority remain inert? It has been suggested that the answer to both questions lie in the cumulative and interactive effects of a range of risk factors. While risk assessment and counter-radicalization take a risk-protective factor approach, there is widespread debate as to what these factors are and which are most important.

Objectives: This review has two primary objectives.

A unique sonographic presentation of prenatal volvulus associated with malrotation.

This is a unique case of prenatal diagnosis of bowel malrotation suspected by an abnormal course of the duodenum. Early detection of volvulus was enabled, leading to timely intervention and a favorable outcome.