Dearomative spirocyclization of ynamides.

Spiro N-heterocycles, particularly aza-spiro piperidines, have shown significant promise in pharmaceutical applications due to their ability to enhance physicochemical properties. Despite their potential, the preparation of these complex structures poses significant challenges. To address this, we propose a one-pot dearomative spirocyclization reaction of ynamides.

Manometric findings in children with eosinophilic esophagitis and persistent post-remission dysphagia.

Objectives: Dysphagia is a frequent symptom of active eosinophilic esophagitis (EoE), but at times it persists despite attaining histologic healing and lack of fibro-stenotic changes. We aimed to describe the manometric findings in this subset of patients.

Methods: A retrospective review of charts between 2013 and 2023 at a tertiary pediatric gastroenterology center, treating roughly 1500 EoE patients per year.

Environmental factors influencing red knot () departure times of relocation flights within the non-breeding period.

Deciding when to depart on long-distance, sometimes global, movements can be especially important for flying species. Adverse weather conditions can affect energetic flight costs and navigational ability. While departure timings and conditions have been well-studied for migratory flights to and from the breeding range, few studies have focussed on flights within the non-breeding season.

Thyroid hormone dysfunction in MOGAD and other demyelinating diseases.

Background: Thyroid hormones play a critical role in both neuronal and glial cell functions. Multiple sclerosis (MS) has increased co-occurrence with autoimmune thyroid diseases, and recent studies have suggested a potential link between neuromyelitis optica spectrum disorder (NMOSD) and thyroid hormones. However, no previous studies have examined the relationship between thyroid hormones and myelin oligodendrocyte glycoprotein-associated demyelination (MOGAD).

Revisiting the species list of freshwater fish in Israel based on DNA barcoding.

Israel's region forms a continental bridge; hence, the freshwater fish fauna in Israel consists of unique populations of species that originated from Africa, Asia, or Europe and are often endemic or at the edge of their distribution range. Worldwide, fish biodiversity suffers significantly from pressures and disturbances of freshwater habitats, especially in arid regions, such as in parts of Israel. Biodiversity conservation requires efficient tools for monitoring changes in populations.

SNG100, a novel topical treatment for moderate atopic dermatitis, in patients aged 6 years or older: A randomised, double-blind, active-controlled trial.

Background: Atopic dermatitis (AD) is one of the most common inflammatory skin diseases. It is associated with significant itch and impaired quality of life. Systemic treatments are efficient but associated with side effects.

Life-threatening bronchospasm induced by an angiotensin-converting enzyme inhibitor in a chronically ventilated patient: Diagnostic pitfalls and literature review.

Cough- and asthma-like symptoms are common adverse reactions to angiotensin-converting enzyme inhibitors (ACEi). However, attributing these symptoms to the use of ACEi might be masked by clinical confounders. We report a 68-year-old female residing in a long-term acute-care facility for patients requiring prolonged invasive mechanical ventilation treated for years with ACEi.

Imprinting of nanoparticles in thin films: Quo Vadis?

Nanomaterials, and especially nanoparticles, have been introduced to almost any aspect of our lives. This has caused increasing concern as to their toxicity and adverse effects on the environment and human health. The activity of nanoparticles, including their nanotoxicity, is not only a function of the material they are made of but also their size, shape, and surface properties.

Stimuli-Responsive Hydrogel Microcapsules Harnessing the COVID-19 Immune Response for Cancer Therapeutics.

The combination of gene therapy and immunotherapy concepts, along recent advances in DNA nanotechnology, have the potential to provide important tools for cancer therapies. We present the development of stimuli-responsive microcapsules, loaded with a viral immunogenetic agent, harnessing the immune response against the Coronavirus Disease 2019, COVID-19, to selectively attack liver cancer cells (hepatoma) or recognize breast cancer or hepatoma, by expression of green fluorescence protein, GFP. The pH-responsive microcapsules, modified with DNA-tetrahedra nanostructures, increased hepatoma permeation by 50 %.

Single- Versus Dual-Chamber Implantable Cardioverter-Defibrillator for Primary Prevention of Sudden Cardiac Death in the United States.

Background Routine addition of an atrial lead during an implantable cardioverter-defibrillator (ICD) implantation for primary prevention of sudden cardiac death, in patients without pacing indications, was not shown beneficial in contemporary studies. We aimed to investigate the use and safety of single- versus dual-chamber ICD implantations in these patients. Methods and Results Using the National Inpatient Sample database, we identified patients with no pacing indications who underwent primary-prevention ICD implantation in the United States between 2015 and 2019.

Fear of predators alters herbivore regulation of soil microbial community function.

Fear of predation can affect important ecosystem processes by altering the prey traits expression that, in turn, regulates the quantity and quality of nutritional inputs to soil. Here, we aimed to assist in bridging a knowledge gap in this cascading chain of events by exploring how risk of spider predation may affect grasshopper prey performances, and the activity of various microbial extracellular enzymes in the soil. Using a mesocosms field-experiment, we found that grasshoppers threatened by spider predation ate less, grew slower, and had a higher body carbon to nitrogen ratio.

Titanium complexes affect biofilm formation.

Biofilms are surface or interface-associated communities of bacterial cells, embedded in a self-secreted extracellular matrix (ECM). Cells in biofilms are 100-1000 times more resistant to antibiotic treatment relative to planktonic cells due to various reasons, including the ECM acting as a diffusion barrier to antibiotic molecules, the presence of persister cells that divide slowly and are less susceptible to cell-wall targeting drugs, and the activation of efflux pumps in response to antibiotic stress. In this study we tested the effect of two titanium(iv) complexes that have been previously reported as potent and non-toxic anticancer chemotherapeutic agents on cells in culture and in biofilm forming conditions.

Archaeomagnetism in the Levant and Mesopotamia Reveals the Largest Changes in the Geomagnetic Field.

Our understanding of geomagnetic field intensity prior to the era of direct instrumental measurements relies on paleointensity analysis of rocks and archaeological materials that serve as magnetic recorders. Only in rare cases are absolute paleointensity data sets continuous over millennial timescales, in sub-centennial resolution, and directly dated using radiocarbon. As a result, fundamental properties of the geomagnetic field, such as its maximum intensity and rate of change have remained a subject of lively discussion.

The aspect ratio effect on the cytotoxicity of inert nano-particles flips depending on particle thickness, and is one of the reasons for the literature inconsistency.

The interaction of inert nano-particles with cells has significant effect on the potential cytotoxicity of the particles. The role of particle aspect ratio in the interaction with cells was largely studied in the literature; however non consistent conclusions were obtained. In the present study a detailed physical model is presented as well as a set of experimental work and a scan of literature data.

Topologically switchable and gated transcription machinery.

Topological barriers control in nature the transcription machinery, thereby perturbing gene expression. Here we introduce synthetically designed DNA templates that include built-in topological barriers for switchable, triggered-controlled transcription of RNA aptamers. This is exemplified with the design of transcription templates that include reversible and switchable topological barriers consisting of a Sr-ion-stabilized G-quadruplex and its separation by kryptofix [2.

I hate you when I am anxious: Anxiety during the COVID-19 epidemic and ideological hostility.

Most previous studies that examined the effect of anxiety on hostility towards a distinct group have focused on cases in which we hate those we are afraid of. The current study, on the other hand, examines the relationship between anxiety in one domain and hostility towards a distinct group that is not the source of that anxiety. We focus here on symptoms of anxiety during the COVID-19 pandemic, which have become increasingly frequent, and show that the implications of such mental difficulties are far-reaching, posing a threat to relationships between ideological groups.

Predictors of survival in elderly patients with coronavirus disease 2019 admitted to the hospital: derivation and validation of the FLAMINCOV score.

Objective: To identify predictors of 30-day survival in elderly patients with coronavirus disease 2019 (COVID-19).

Methods: Retrospective cohort study including patients with COVID-19 aged ≥65 years hospitalized in six European sites (January 2020 to May 2021). Data on demographics, comorbidities, clinical characteristics, and outcomes were collected.

The Late Middle Pleistocene mammalian fauna of Oumm Qatafa Cave, Judean Desert: taxonomy, taphonomy and palaeoenvironment.

The Middle Pleistocene archaeological record of the southern Levant has proven key to understanding human evolution and intercontinental faunal biogeography. Knowledge of archaeological sites of that period in the southern Levant is biased, with most Middle Pleistocene localities in the Mediterranean areas in the north, despite the mosaic of environments that mark the entire region. A key Middle Pleistocene location in the Judean Desert - on the eastern margin of the Mediterranean zone - is the site of Oumm Qatafa, excavated in the early 1900s, which yielded a faunal collection spanning an estimated time period of 600-200 kya.

Planetary, inertia-gravity and Kelvin waves on the -plane and -plane in the presence of a uniform zonal flow.

A linear wave theory of the Rotating Shallow-Water Equations (RSWE) is developed in a channel on the midlatitude -plane or -plane in the presence of a uniform mean zonal flow that is balanced geostrophically by a meridional gradient of the fluid surface height. Here we show that this surface height gradient is a potential vorticity (PV) source that generates Rossby waves even on the -plane similar to the generation of these waves by PV sources such as the -effect, shear of the mean flow and bottom topography. Numerical solutions of the RSWE show that the resulting Rossby, Poincaré and "Kelvin-like" waves differ from their counterparts without mean flow in both their phase speeds and meridional structures.

Biocatalytic cascades and intercommunicated biocatalytic cascades in microcapsule systems.

Biomolecule-loaded nucleic acid-functionalized carboxymethyl cellulose hydrogel-stabilized microcapsules (diameter 2 μm) are introduced as cell-like containments. The microcapsules are loaded with two DNA tetrahedra, T and T, functionalized with guanosine-rich G-quadruplex subunits, and/or with native enzymes (glucose oxidase, GOx, and/or β-galactosidase, β-gal). In the presence of K-ions and hemin, the T/T tetrahedra constituents, loaded in the microcapsules, assemble into a hemin/G-quadruplex bridged tetrahedra dimer DNAzyme catalyzing the oxidation of Amplex Red to Resorufin by generating HO.