A case of acquired syphilis in an infant through mouth-to-mouth transmission of prechewed food.

Background: Patients with syphilis are the only source of infection, which can be transmitted through sexual contact and mother-to-child and blood transmission, and rarely through contaminants. The clinical manifestations of syphilis are complex and variable, and can be easily misdiagnosed. This article reports a case of syphilis in a child with "psoriasis"-like lesions who was fed pre-chewed food.

Study on the apoptosis of human melanoma cells induced by solanine in vitro and its mechanisms.

Melanoma (malignant melanoma, MM) is a highly aggressive tumor, ranking as the third most common cutaneous malignancy and characterized by high metastatic potential, high mortality rates, and poor prognosis. Solanine, a major steroidal alkaloid found in potatoes, has widely reported anticancer benefits, though its inhibitory effects on melanoma cells are less studied. This study aimed to observe the effects of solanine on the proliferation, apoptosis, and related apoptotic proteins in melanoma A375 and A2058 cells and to investigate its possible anti-tumor mechanisms.

A time series study of the association between extreme temperature and ozone on varicella incidence.

This study aimed to discuss the effects of extreme temperatures and ozone on the incidence of varicella in Shijiazhuang City from 2014 to 2022, which provides new ideas for preventing public health events. METHODS We collected varicella cases in Shijiazhuang, China, from 2014 to 2022 and evaluated the relationship between temperature extremes and ozone on varicella incidence by building distributional lag nonlinear models. The analysis was stratified by age and sex, with 19,188 varicella cases reported.

CircAKR1B10 interacts with EIF4A3 to stabilize AURKA and promotes IL-22-induced proliferation, migration and invasion in keratinocytes.

Circular RNAs (circRNAs) are demonstrated to be involved in psoriasis progression. CircRNAs can act as RNA-binding protein (RBP) sponges. Here, we investigated the action of circAKR1B10 in psoriasis, and explored the potential proteins interacted with circAKR1B10.

Genetic analysis of seven patients with inherited ichthyosis and Nagashima‑type palmoplantar keratoderma.

Inherited ichthyosis comprises a series of heterogeneous dermal conditions; it mainly manifests as widespread hyperkeratosis, xerosis and scaling of the skin. At times, overlapping symptoms require differential diagnosis between ichthyosis and several other similar disorders. The present study reports seven patients with confirmed or suspected to be associated with ichthyosis by conducting a thorough clinical and genetic investigation.