Connecting the liquid fragility to the average weakest metal-oxygen bond of its crystal in oxides.

Glass and crystal are inherently different material states in terms of their structural and physical features; consequently, the direct quantitative connection between crystal and glass is lacking. Herein, we first show that the liquid fragility m, which is featured by the negative departure degree of viscosity with the temperature at the glass transition temperature (Tg), has a direct exponential correlation with the ratio of the average longest metal-oxygen and the average phosphorus, silicon, or boron-oxygen bond lengths of the crystal in various oxides including phosphates, silicates, and borates. Such a result can be rationalized by the fact that the fragility m in these glass-formers is associated with the total network rigidity determined by the weakest bond due to the "bucket effect" and the bond pair inheritance of glass from that of the crystal.

Integrative Lipid Pseudotargeted Metabolomics and Amino Acids Targeted Metabolomics Unravel the Therapeutic Mechanism of Rhizoma Paridis Saponins on Experimental Colitis of Damp-Heat Type.

Purpose: Inflammatory bowel disease (IBD) is a serious disease that affects the metabolism and inflammatory responses of human beings. From the perspective of traditional Chinese medicine, damp-heat syndrome is one of the main syndromes of IBD. Rhizoma Paridis, also known as the root of Paris polyphylla, a well-known herbal medicine used in China, is used to treat IBD with damp-heat syndrome (IBD-DH).

Enhancing the nutritional value and antioxidant properties of foxtail millet by solid-state fermentation with edible fungi.

Foxtail millet is typically dehulled before consumption or processing. However, foxtail millet bran also contains abundant phenolic compounds and other nutrients. Edible fungi have rich extracellular enzyme systems; are environmentally friendly and safe for consumption; and have been shown to effectively degrade lignin and cellulose.

Synergistic Modulation of Orientation and Steric Hindrance Induced by Alkyl Chain Length in Ammonium Salt Passivator Toward High-performance Inverted Perovskite Solar Cells and Modules.

Organic ammonium salts are extensively utilized for passivating surface defects in perovskite films to mitigate trap-assisted nonradiative recombination. However, the influence of alkyl chain length on the molecular orientation and spatial steric hindrance of ammonium salt remains underexplored, hindering advancements in more effective passivators. Here, a series of organic ammonium salts is reported with varying alkyl chain lengths to passivate surface defects and optimize band alignment.

Glucose Disorders in Patients With Pheochromocytoma/Paraganglioma: Profile and Influence Effects in a Large Cohort With 705 Patients.

Objective: Some patients with pheochromocytoma and paraganglioma (PPGL) suffer from glucose metabolic disorders. The aim was to investigate the relationship between glucose metabolic disorders and catecholamine levels in 705 patients with PPGL.

Methods: A retrospective analysis was conducted on the clinical data of 705 patients diagnosed with PPGL at Peking Union Medical College Hospital from 2018 to 2023.

A prospective multicenter birth cohort in China: pregnancy health atlas.

The China Prospective Multi-Center Birth Cohort Study was launched in 2022. In collaboration with medical centers in 12 cities, it aims to establish a high-quality, multidimensional cohort comprising 20,000 natural pregnancy and assisted reproductive families. As of June 26, 2024, 12,911 pregnant women have participated in this study, and 161,122 biological samples have been collected.

Neuronal basis of high frequency fMRI fluctuation: direct evidence from simultaneous recording.

Resting-state functional magnetic resonance imaging (RS-fMRI) has been extensively utilized for noninvasive investigation of human brain activity. While studies employing simultaneous recordings of fMRI and electrophysiology have established a connection between the low-frequency fluctuation (< 0.1 Hz) observed in RS-fMRI and the local field potential (LFP), it remains unclear whether the RS-fMRI signal exhibits frequency-dependent modulation, which is a well-documented phenomenon in LFP.

Guideline for the Prevention and Treatment of Metabolic Dysfunction-associated Fatty Liver Disease (Version 2024).

With the rising epidemic of obesity, metabolic syndrome, and type 2 diabetes mellitus in China, metabolic dysfunction-associated non-alcoholic fatty liver disease has become the most prevalent chronic liver disease. This condition frequently occurs in Chinese patients with alcoholic liver disease and chronic hepatitis B. To address the impending public health crisis of non-alcoholic fatty liver disease and its underlying metabolic issues, the Chinese Society of Hepatology and the Chinese Medical Association convened a panel of clinical experts to revise and update the "Guideline of prevention and treatment of non-alcoholic fatty liver disease (2018, China)".

Generation of a human induced pluripotent stem cell (iPSC) line from a patient with a CDKL5 gene mutation.

CDKL5(Cyclin-dependent kinase-like 5) encodes a kinase that may influence components of molecular pathways associated with MeCP2 and regulates axon outgrowth, dendritic morphogenesis, and synapse formation early in life. Here, we report an induced pluripotent stem cell (iPSC) line generated from an epilepsy patient harboring the CDKL5 c.2684C > T (p.

Why do patients with pheochromocytomas/paragangliomas exhibit significantly inconsistent elevation of catecholamines and their metabolites? a large Chinese cohort study.

Objectives: Inconsistent elevation of catecholamines (CAs) and metanephrines (MNs) was observed in pheochromocytomas/paragangliomas (PPGLs). This study aimed to explore its potential causes and report the diagnostic efficacy of MNs and CAs in a large Chinese PPGL cohort.

Methods: Clinical data and results of hormone tests were retrospectively collected.

Comparing conventional and action video game training in visual perceptual learning.

Action video game (AVG) playing has been found to transfer to a variety of laboratory tasks in visual cognition. More recently, it has even been found to transfer to low-level visual "psychophysics tasks. This is unexpected since such low-level tasks have traditionally been found to be largely "immune" to transfer from another task, or even from the same task but a different stimulus attribute, e.

Deciphering microbial assembly and coexistence in rivers subjected to long-term reclaimed water replenishment.

Reclaimed water recharge into rivers is an important supplementary approach to address water resource shortage in arid and semi-arid areas worldwide. However, the ecology impacts of reclaimed water recharge on the rivers are still unknown, especially for the microbial assemble and species coexistence in different seasons. Here, the evolution of microbiome and its response to different reasons in the Jialu River, which was subjected to long-term reclaimed water recharge, is investigated by using 16S rRNA gene sequencing and multivariate statistical methods.

Surface fluorination mediated electro-oxidative degradation of HFPO-DA on boron-doped diamond electrode.

Heptafluoropropylene oxide dimer acid (HFPO-DA), as an alternative to perfluorooctanoic acid (PFOA), has been shown to pose similar environmental and health risks as other perfluorinated compounds. The electrochemical-based advanced oxidation processes are promising techniques for the treatment of perfluorinated compounds, and the boron-doped diamond (BDD) anode could degrade HFPO-DA under mild conditions. However, the roles of radicals in the degradation and how to overcome the steric hindrance of the -CF branch on the carboxyl group were not yet clear.

Histone demethylase JMJ713 interaction with JMJ708 modulating H3K36me2, enhances rice heat tolerance through promoting hydrogen peroxide scavenging.

The Earth is currently undergoing rapid warming cause of the accumulation in greenhouse gas emissions into the atmosphere and the consequent rise in global temperatures. High temperatures can bring the effects on rice development and growth and thereby decrease rice yield. In this study, we have identified that both JMJ713 and JMJ708 possess distinct histone demethylase activities.

A novel ATP2A2 mutation in Darier and genotype phenotype: correlation analysis.

Background: Darier's disease (DD) is a skin disorder caused by mutations in the ATP2A2 gene. Researchers have been investigating the correlation between genotype and phenotype in DD. Understanding the genotype-phenotype relationship in DD can enhance our comprehension of the genetic background and phenotypic characteristics of the condition, as well as the relationship between its systemic and localized manifestations.

Visual search attentional bias modification reduced the attentional bias in socially anxious individuals.

Recent years have raised questions about the effectiveness of attentional bias modification (ABM) in individuals with social anxiety. In the current study, we employed a novel training method-ABM-positive-search training-to modify attentional bias in socially anxious individuals. The attentional bias was measured using the dot-probe task, and brain electrical activity was recorded.

Single cell analysis identified a basal cell transition state associated with the development and progression of bladder cancer.

Background: Bladder cancer (BC) is a prevalent malignancy characterized by significant cellular heterogeneity. While single-cell multi-omics studies have provided valuable insights, much of the existing data remains underexplored, limiting our understanding of BC's molecular mechanisms. Uncovering the pathogenesis of BC and finding new treatment methods are urgent problems to be solved.

The mediating effect of work-life balance on the relationship between work-family conflict and psychological well-being among Chinese working women.

The study aims to explore whether work-life balance mediates the impact of work-family conflict and its dimensions on psychological well-being. Using a survey method, data were collected from a sample of 258 working women in Hebei province in China. The analysis was carried out using IBM SPSS and the PROCESS macro in order to test the mediation model.