5,462 results match your criteria: "Hebei Normal University of Science & Technology[Affiliation]"

Bisphenol A (BPA) is a contaminant widely found in food packaging that can reduce sperm quality and impair male fertility. Zinc (Zn) is an important antioxidant involved in many important biological functions. The aim of this study was to explore the protective effect and mechanism of Zn on reproductive toxicity induced by BPA.

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Time-resolved fluorescence studies reveal differences in dynamic motion between main proteases of SARS-CoV-2 and SARS-CoV.

Int J Biol Macromol

December 2024

School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. Electronic address:

The main protease (M) is an attractive drug target for inhibiting the coronavirus. Lots of research has focused on the static viewpoint of the M, such as the X-ray crystal structure, inhibitors design, and the transition between monomer and dimer. However, the attention to the dynamical features of M is limited, which is essential for a deeper determination of the properties of the target protein.

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Effects of chronic cold stress and thermal stress on growth performance, hepatic apoptosis, oxidative stress, immune response and gut microbiota of juvenile hybrid sturgeon (Acipenser baerii ♀ × A. schrenkii ♂).

Fish Shellfish Immunol

December 2024

Laboratory of Aquatic Animal Nutrition and Ecology, College of Life Sciences, Hebei Normal University, Shijiazhuang, 050024, China; Hebei Key Laboratory of Animal Physiology, Biochemistry and Molecular Biology, Shijiazhuang, 050024, China; Hebei Collaborative Innovation Center for Eco-Environment, Shijiazhuang, 050024, China. Electronic address:

The current study was conducted to investigate the effects of chronic cold stress and thermal stress on the growth performance, hepatic oxidative status, immune response, apoptosis and gut microbiota in juvenile hybrid sturgeon. The fish (initial mean weight: 21.4 ± 0.

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Article Synopsis
  • * Total concentrations of four PAEs in tobacco leaves ranged from 49.0 to 273 ng/g, with di-(2-ethylhexyl) phthalate (DEHP) being the most prevalent at an average of 44.4 ng/g, especially in economically developed regions.
  • * Health risk assessments indicate that while the hazard quotients for the measured PAEs are below 1, suggesting minimal non-carcinogenic risk to smokers, a low carcinogenic risk from DEHP was also identified
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Rational design of 1, 2, 4, 5-tetraphenyl-1H-imidazole-based AIEgens with tunable intramolecular charge transfer and restricted intramolecular rotation processes for multifunctional sensing.

Spectrochim Acta A Mol Biomol Spectrosc

December 2024

National Demonstration Center for Experimental Chemistry Education, Hebei Key Laboratory of Organic Functional Molecules, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang, Hebei 050024, PR China. Electronic address:

Aggregation-induced emission fluorogens (AIEgens) with intramolecular charge transfer (ICT) characteristic are widely used in the detection of various analytes owing to their highly tunable fluorescence emission properties. However, facilely synthesis of AIEgens with ICT characteristic for multiple sensing is still rare and limited in use. In this work, two new AIEgens of 1,2-bis(4-alkoxycarbonylphenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole (AMI) and its hydrolyzed derivative 1,2-bis(4-carboxylphenyl)-4,5-bis(4-methoxyphenyl)-1H-imidazole (CMI) were facilely synthesized with donor-π-acceptor (D-π-A) structures.

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Enabling High-Performance Multi-Resonant TADF Emitters via Intramolecular Hydrogen Bond.

Chemistry

December 2024

Hebei Key Laboratory of Organic Functional Molecules, Hebei Technology Innovation Center for Energy Conversion Materials and Devices, College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024, PR China E-mail address.

Hydrogen bonds (HBs), prevalent strong interactions in organic compounds, can effectively constrain single bond rotation, leading to rigid planar configurations. This rigidity enhances emission efficiency and narrows the emission spectrum of luminescent materials. Recent advances have leveraged HBs to advance high-performance donor-acceptor thermally activated delayed fluorescence (TADF) materials.

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Fluorination Strategy for Benzimidazole Core Based Electron Acceptors Achieving over 19% Efficiency for Ternary Organic Solar Cells.

ACS Appl Mater Interfaces

December 2024

Beijing Advanced Innovation Center for Soft Matter Science and Engineering & State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, P. R. China.

The expansion of two-dimensional conjugated systems in nonfullerene electron acceptors (NFAs) has significantly advanced the molecular design and efficiency potential of organic solar cells (OSCs). This study introduces a novel class of NFAs featuring a benzimidazole core with varying degrees of peripheral fluorination, designated as YIS-4F, YIS-6F, and YIS-8F, respectively. Through systematic modulation of fluorine content, we observed that OSCs incorporating YIS-6F achieved the highest power conversion efficiency (PCE) of 17.

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BPA Exacerbates Zinc Deficiency-Induced Testicular Tissue Inflammation in Male Mice Through the TNF-α/NF-κB/Caspase8 Signaling Pathway.

Biol Trace Elem Res

December 2024

Hebei General Hospital, NO.348 Heping West Road, Xinhua District, Shijiazhuang City, P.R. 050051, Hebei Province, China.

Bisphenol A (BPA) is an endocrine-disrupting chemical that is toxic to reproduction. Zinc (Zn) plays an important role in male reproductive health. Zn deficiency (ZD) can co-exist with BPA.

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Spodoptera litura (S. litura) is a polyphagous pest of the family Lepidoptera, which causes damage and yields losses to many crops. The long-term use of chemical pesticides for control not only seriously threatens environmental health, but also causes S.

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The modulation of cholecystokinin receptor 1 in the NAc core input from VTA on METH-induced CPP acquisition.

Life Sci

January 2025

College of Forensic Medicine, Hebei Medical University, Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, Shijiazhuang, Hebei Province, China; Key Laboratory of Neural and Vascular Biology, Ministry of Education, Shijiazhuang, Hebei Province, China; Hainan Tropical Forensic Medicine Academician Workstation, Haikou, Hainan Province, China. Electronic address:

Article Synopsis
  • - The study investigates how cholecystokinin (CCK) receptors, specifically CCK1 receptors, play a role in methamphetamine (METH)-induced addiction by affecting the nucleus accumbens core (NAcC) and its connections with other brain areas.
  • - Using a mouse model, researchers created a condition that mimics METH addiction and explored the effects of genetically knocking out CCK receptor subtypes to understand their specific roles in the METH addiction process.
  • - Results showed that disruption of CCK1R in NAcC hindered the development of METH-induced conditioned place preference and altered neuronal excitability, indicating that CCK1R is essential for the synaptic changes in the
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Introduction: Previous research has highlighted the influence of visual search (VS) on reading comprehension (RC); however, the underlying mechanisms of this effect remain poorly understood, particularly in children with reading disabilities. This study explores disparities in VS, word detection skills (WD), reading fluency (RF), and RC between Chinese children with developmental dyslexia (DD) and their typically developing peers across different age groups.

Methods: The sample comprised 191 students from grades 2, 4, and 6, including 92 children with dyslexia and 99 chronological age-matched controls.

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Affective Norms for German as a Second Language (ANGL2).

Behav Res Methods

December 2024

National Research Centre for Foreign Language Education, Beijing Foreign Studies University, No. 2 Xisanhuan North Road, Beijing, 100089, Haidian District, China.

The present study introduces affective norms for a set of 880 German words rated by learners of German as a second language (L2), i.e., the Affective Norms for German as a Second Language (ANGL2).

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Periodontitis is a chronic inflammation of the periodontal support tissues. The typical symptoms of periodontitis are inflammation and alveolar bone resorption. Chitong Xiaoyanling Granules (CXG) is composed of 10 Chinese herbs, which have the efficacy of dispersing wind, clearing heat, cooling blood, and relieving pain.

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Lactate Dehydrogenase Inhibition Protects against Hepatic Fibrosis by Regulating Metabolic Reprogramming of Hepatic Stellate Cells.

J Agric Food Chem

December 2024

Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Provincial Technology Innovation Center for Anti-tumor Molecular Targeting New Drugs Development, College of Life Science, Hebei Normal University, Shijiazhuang 050024, China.

Hepatic stellate cells (HSCs) activation results in liver fibrosis. When HSCs are activated, metabolism is reprogrammed. However, metabolic alteration in HSCs activation has not been sufficiently addressed.

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AlBC with High Ambipolar Mobility Driven by a Unique B-C Framework.

J Am Chem Soc

December 2024

State Key Laboratory of Metastable Materials Science & Technology and Hebei Key Laboratory of Microstructural Material Physics, School of Science, Yanshan University, Qinhuangdao 066004, China.

The development of materials with high ambipolar mobility is pivotal for advancing multifunctional applications, yet such materials remain scarce. Presently, cubic boron arsenide (BAs) stands out as the premier ambipolar material, demonstrating an ambipolar mobility of ∼1600 cm V s at room temperature [ 2022, 377, 433 and 2022, 377, 437]. Herein, we illustrate that semiconducting AlBC, featuring a nonclathrate B-C framework in which a C atom bonds to the vertices of four distorted hexagonal antiprism B units via quasi-sp hybridization, is predicted to possess ambipolar carrier transport behavior.

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Two-Dimensional Rare-Earth Metal Phosphides: From Weyl Semimetal to Semiconductor.

ACS Appl Mater Interfaces

December 2024

State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Northwestern Polytechnical University, Xi'an 710072, China.

Two-dimensional (2D) nanomaterials have garnered extensive attention owing to their unique properties and versatile application. Here, a family of 2D rare-earth metal phosphides (MP, M = Sc, Y, La) and their derivatives MPOT (T = F, OH) is developed to find their topological and electronic properties on the basis of density functional theory simulations. We show that the 2D MP compounds are most possibly obtained from thermodynamically stable MInP by chemical exfoliation.

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Objective: To explore the clinical efficacy of modified limbal stem cell transplantation(Modified LSC transplantation) and bandage contact lens(BCL) implantation in pterygium surgery.

Methods: A total of 479 patients with primary pterygium who were admitted to our hospital from March 2019 to March 2023 were randomly divided into three groups: the normal group (Group A: 89 patients), the control group (Group B: 195 patients), and the modified group (Group C: 195 patients). Each group received different intervention measures.

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Article Synopsis
  • * MA promotes autophagy in prostate cancer cells by increasing specific protein expressions and decreasing others, which helps with cell degradation and recycling.
  • * The study showed that MA also induces ferroptosis (a form of cell death) by manipulating certain metabolic pathways, and in vivo tests demonstrated that it significantly reduced tumor growth in mice.
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Spatiotemporal variability of groundwater chemistry, source identification and health risks in the southern Chinese Loess Plateau.

Ecotoxicol Environ Saf

December 2024

Limited Company of Beijing Satellite Manufacturing Factory, Beijing 100094, PR China.

Article Synopsis
  • Groundwater pollution in the loess plateau regions is a growing global issue, influenced by both natural and human activities, leading to significant concerns about water quality and health risks.
  • A study of 146 water samples from two river basins revealed that the Malian River Basin has higher variability in water chemistry and greater pollution levels compared to the Upper Jinghe River Basin, though there are signs of improvement over time in the Malian River Basin's quality.
  • The research identified geogenic sources as the primary detriment to water quality, while anthropogenic activities like agriculture and coal mining also contributed, with notable risks from nitrate contamination that pose a greater health threat to children, particularly in the Malian River Basin.
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Characterization and functional properties of walnut protein fibrils for enhanced bioaccessibility of CoQ10 and ALA.

Int J Biol Macromol

January 2025

State Key Laboratory of Food Science and Resources, School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214122, China.

Article Synopsis
  • - The study explored the creation of walnut protein fibrils (WPF) using acid-heat treatment and how these fibrils can improve the delivery of hydrophobic compounds like CoQ10 and ALA in emulsions.
  • - Longer treatment times altered the protein structure, increasing β-sheet content and enhancing the emulsifying properties, which led to more stable emulsions that can better withstand environmental changes and oxidative factors.
  • - Compared to unmodified walnut protein, emulsions stabilized by WPF showed improved bioaccessibility for CoQ10 and ALA, suggesting this delivery system could effectively incorporate beneficial compounds into beverages.
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Positively-charged, chalcone-hydroxypyrone hybrid ruthenium(II)-arene complexes functionalized with ethacrynic acid: Synthesis, characterizaion, and antitumor effect.

J Inorg Biochem

February 2025

Key Laboratory of Chemical Biology of Hebei Province; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education; State Key Laboratory of New Pharmaceutical Preparations and Excipients, College of Chemistry & Materials Science, Hebei University, Baoding 071002, China. Electronic address:

A new family of ethacrynic acid-functionalized, chalcone-hydroxypyrone hybrid ruthenium(II)-arene complexes (4a-4e) have been designed, synthesis and fully characterized by H and C NMR, ESI-MS, elemental analysis, and melting point tests. The molecular structure of 3a, one of the precursor complexes, has been determined by single-crystal X-ray diffraction. The cytotoxicity of the obtained complexes toward human cancer cell lines such as HeLa, MGC803, A549, MDA-MB-231, and MCF-7 cells have been investigated by MTT assay.

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