5 results match your criteria: "Hebei Medical University Shijiazhuang 050017 P.R. China zhanglantong@263.net +86-311-86266419 +86-311-86266419.[Affiliation]"

Eupatorin, a bioactive compound extracted from Java tea (), possesses potent anti-cancer, anti-inflammatory and vasodilation activities. To date, no pharmacokinetics studies on eupatorin have yet been performed. Here, we established and validated a sensitive and selective LC-MS/MS (liquid chromatography-tandem mass spectrometry) approach for determining plasma eupatorin in rats.

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Eriocitrin is one of the major active constituents of lemon fruit, and it possesses strong antioxidant, lipid-lowering, anticancer and anti-inflammatory activities and has long been used in food, beverages and wine. In this study, for the first time, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry method (LC/MS/MS) with protein precipitation was developed and validated for the analysis of eriocitrin in rat plasma. Chromatographic separation was achieved using a mobile phase, comprising 0.

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Eriocitrin, a main flavonoid in lemons, possesses strong antioxidant, lipid-lowering and anticancer activities and has long been used in food, beverages and wine. However, its metabolism and is still unclear. In this study, an efficient strategy was developed to detect and identify metabolites of eriocitrin by using ultra-high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) based on online data acquisition and multiple data processing techniques.

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Article Synopsis
  • Osthole (OST) is a compound with significant pharmacological benefits such as anticancer properties and neuroprotection, and this study aims to identify its metabolites using advanced techniques like UHPLC-Q-TOF-MS.
  • A total of 72 metabolites of OST were detected across various biological samples (liver microsomes, plasma, bile, urine, and feces), revealing that mono-oxidation and glucuronide conjugation are major metabolic reactions.
  • Unique metabolic pathways were identified for the first time, including phosphorylation and cysteine conjugation, which aids in understanding OST's biological mechanisms and its safety and efficacy in use.
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Liquiritin (LQ), the main bioactive constituent of licorice, is a common flavoring and sweetening agent in food products and has a wide range of pharmacological properties, including antidepressant-like, neuroprotective, anti-cancer and anti-inflammatory properties. This study investigated the metabolic pathways of LQ (rat liver microsomes) and (rat model) using ultra high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Moreover, supplementary tools such as key product ions (KPIs) were employed to search for and identify compounds.

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