5 results match your criteria: "Hebei Medical University Shijiazhuang 050017 P.R. China zhanglantong@263.net +86-311-86266419 +86-311-86266419.[Affiliation]"
Eupatorin, a bioactive compound extracted from Java tea (), possesses potent anti-cancer, anti-inflammatory and vasodilation activities. To date, no pharmacokinetics studies on eupatorin have yet been performed. Here, we established and validated a sensitive and selective LC-MS/MS (liquid chromatography-tandem mass spectrometry) approach for determining plasma eupatorin in rats.
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March 2020
Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University Shijiazhuang 050017 P.R. China +86-311-86266419 +86-311-86266419.
Eriocitrin is one of the major active constituents of lemon fruit, and it possesses strong antioxidant, lipid-lowering, anticancer and anti-inflammatory activities and has long been used in food, beverages and wine. In this study, for the first time, a rapid, selective, and sensitive liquid chromatography-tandem mass spectrometry method (LC/MS/MS) with protein precipitation was developed and validated for the analysis of eriocitrin in rat plasma. Chromatographic separation was achieved using a mobile phase, comprising 0.
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August 2019
Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University Shijiazhuang 050017 P. R. China +86-311-86266419 +86-311-86266419.
Eriocitrin, a main flavonoid in lemons, possesses strong antioxidant, lipid-lowering and anticancer activities and has long been used in food, beverages and wine. However, its metabolism and is still unclear. In this study, an efficient strategy was developed to detect and identify metabolites of eriocitrin by using ultra-high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS) based on online data acquisition and multiple data processing techniques.
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April 2018
Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University 361 East Zhongshan Road Shijiazhuang Hebei 050017 P. R. China +86-311-86266419 +86-311-86266419.
RSC Adv
March 2018
Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University Shijiazhuang 050017 P. R. China +86-311-86266419 +86-311-86266419.
Liquiritin (LQ), the main bioactive constituent of licorice, is a common flavoring and sweetening agent in food products and has a wide range of pharmacological properties, including antidepressant-like, neuroprotective, anti-cancer and anti-inflammatory properties. This study investigated the metabolic pathways of LQ (rat liver microsomes) and (rat model) using ultra high-performance liquid chromatography coupled with hybrid triple quadrupole time-of-flight mass spectrometry (UHPLC-Q-TOF-MS/MS). Moreover, supplementary tools such as key product ions (KPIs) were employed to search for and identify compounds.
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