Doxorubicin-loaded nanoparticle coated with endothelial cells-derived exosomes for immunogenic chemotherapy of glioblastoma.

Treatments of glioblastoma (GBM) have not been very effective, largely due to the inefficiency of drugs in penetrating the blood brain barrier (BBB). In this study, we investigated the potential of exosome-coated doxorubicin (DOX)-loaded nanoparticles (ENP) in BBB penetration, inducing immunogenic cell death (ICD) and promoting survival of GBM-bearing mice. DOX-loaded nanoparticles (NP) were coated with exosomes prepared from mouse brain endothelial bEnd.

1.5T magnetic resonance imaging in evaluating fetal head and abdomen malformations: a preliminary study.

Objective: Magnetic resonance imaging (MRI) is increasingly used in the diagnosis of fetal malformations. The purpose of this study was to determine the diagnostic value of 1.5T MRI in fetal head and abdominal malformations.

Efficacy and safety of neoadjuvant chemoradiotherapy plus apatinib for patients with locally advanced, HER2-negative, Siewert's type II-III adenocarcinoma of esophagogastric junction: a single-arm, open-label, phase II trial.

This study aimed to investigate the efficacy and safety of concurrent neoadjuvant chemoradiotherapy (CRT) plus apatinib in treating locally advanced, HER2-negative, Siewert's type II-III adenocarcinoma of esophagogastric junction (AEG) patients. Thirty eligible patients were analyzed in this single-arm, open-label, phase II trial. Patients received neoadjuvant regimen as follows: two cycles of apatinib (orally, 250 mg/day on day 1-28), two cycles of capecitabine (orally, 1,000 mg/m twice daily on day 1-14), oxaliplatin (intravenously, 130 mg/m on day 1), and concurrent radiotherapy (a total dose of 45 Gy in 25 fractions) started on day 1 of chemotherapy.

Expression of LINC01606 in multiple myeloma and its effect on cell invasion and migration.

Unlabelled: Given the increasing incidence of multiple myeloma (MM) in recent years, a full understanding of its pathogenesis to find effective molecular markers carries huge implications for future clinical diagnosis and treatment of MM. As the research advances, accumulating studies have pointed out that long non-coding RNAs (LncRNAs) may be the key to the future diagnosis and treatment of neoplastic diseases.

Objective: This study investigated the clinical implications of LncRNA LINC01606 in MM and its effects on the biological behavior of MM cells.

The risk factors for postoperative acute respiratory distress syndrome in Stanford type a acute aortic dissection patients.

Objective: To explore the risk factors for postoperative acute respiratory distress syndrome (ARDS) in Stanford type A acute aortic dissection (AAD) patients.

Methods: This study included 64 patients with Stanford type A AAD who underwent Sun's procedure. The patients were divided into an ARDS group (PaO/FiO < 200 mmHg) and a non-ARDS group (PaO/FiO ≥ 200 mmHg).

Small intestinal bacterial overgrowth and evaluation of intestinal barrier function in patients with ulcerative colitis.

Objective: To investigate the small intestinal bacterial overgrowth (SIBO) and to evaluate the intestinal barrier function in ulcerative colitis (UC) patients treated with mesalazine and rifaximin.

Methods: 96 patients undergoing the methane-hydrogen breath test in our hospital from January 2018 to January 2020 were enrolled in the study group, and 40 healthy persons were enrolled in the control group during this period. The SIBO positive rate of the two groups were collected and compared.

A correlation analysis of the serum hepcidin concentrations and viral loads in HCV-infected patients.

Objective: To investigate the correlation between the serum hepcidin levels and the viral loads in hepatitis C virus (HCV) infected patients.

Methods: Sixty HCV-infected patients (the study group) and 50 healthy controls (the control group) were recruited as the study cohort. The liver function and inflammation-related parameters were compared, and the 60 HCV patients were divided into mild (G1-G2), moderate (G3), and severe (G4) groups according to each patient's inflammatory activity grade (G).

Cerebroprotein hydrolysate-I protects senescence-induced by D-galactose in PC12 cells and mice.

Cerebroprotein hydrolysate-I (CH-I)，a mixture of peptides extracted from porcine brain tissue，has shown a neuroprotective effect, but its role in brain senescence is unclear. In the present study, we established a senescence model of PC12 cells and mice to investigate the effect of CH-I on brain senescence via JAK2/STAT3 pathway. The results showed that CH-I could improve cell viability, inhibit the apoptosis of cells, and reduce the senescence-positive cells induced by D-galactose.

Plasma exchange therapy for acute necrotizing encephalopathy of childhood.

Importance: Acute necrotizing encephalopathy (ANE) is a rare disease with high mortality. Plasma exchange (PLEX) has recently been reported to treat ANE of childhood (ANEC), but its efficacy is uncertain.

Objective: This study aimed to investigate the effectiveness of PLEX on ANEC.

Molecular crowding effects on the biochemical properties of amyloid β-heme, Aβ-Cu and Aβ-heme-Cu complexes.

Heme as a cofactor has been proposed to bind with β-amyloid peptide (Aβ) and the formed Aβ-heme complex exhibits enhanced peroxidase-like activity. So far, studies on the interactions between heme, Cu and Aβ have been exclusively performed in dilute solution. However, the intracellular environment is highly crowded with biomolecules.

Effect of decitabine and thalidomide on the immunological effect and bone marrow mesenchymal stem cells of patients with myelodysplastic syndrome.

Objective: This study intended to investigate the therapeutic effect of decitabine and thalidomide on myelodysplastic syndrome (MDS), immunological effect and effective mesenchymal stem cells (MSCs).

Methods: Altogether 62 patients with MDS diagnosed in our hospital were selected. Patients who received 5-day treatment mainly and received decitabine from the 1 day to the 5 day were collected as group A (A), while patients who received thalidomide 1 to 5 day as in group A were collected as group B (B).

Lycorine hydrochloride inhibits melanoma cell proliferation, migration and invasion via down-regulating p21.

Lycorine hydrochloride (LH) is an active ingredient sourced from the medicinal herb . Previous studies have suggested that LH exerts tumor suppression activity in several human cancers. However, the anti-cancer effect of LH in melanoma and the potential molecular mechanisms still need to be further studied.

Ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis: efficacy, impact on quality of life and cost-effectiveness analysis.

Objective: To investigate the efficacy of ibandronate sodium and zoledronate sodium in the treatment of senile osteoporosis and their impact on quality of life, and to analyze the cost-effectiveness.

Methods: A retrospective study was conducted on 215 patients with senile osteoporosis, who were admitted to our hospital from January 2017 to June 2019. Among them, 115 cases treated with ibandronate sodium were set to group A and 100 cases treated with zoledronate sodium were set to group B.

The clinical value of color Doppler ultrasonography in measuring the hemodynamics of liver cirrhosis patients' portal and splenic veins.

Objective: To investigate the clinical value of color Doppler ultrasonography (CDUS) in measuring the hemodynamics of liver cirrhosis (LC) patients' portal and splenic veins.

Methods: The clinical data of 81 LC patients admitted to our hospital were collected retrospectively and classified into Group A, and the clinical data from 51 healthy volunteers were classified into Group B. All the patients were examined with CDUS, and the ultrasonography images were analyzed.

[Effect of EDTA and hyaluronic acid on the activity of periodontal ligament fibroblasts and the expression of cytokines].

Purpose: To investigate the effect of ethylenediaminetetraacetic acid (EDTA) and hyaluronic acid (HA) on the activity of periodontal ligament fibroblasts (PDLFs) and the expression of cytokines.

Methods: Twelve wisdom teeth extracted due to orthodontics treatment were selected and prepared into 5 mm×4 mm root pieces, then divided into EDTA group, HA group, EDTA+HA group and untreated group according to different treatment methods. They were placed in the well plate and PDLFs inoculated on the root piece.

[Expression and clinical significance of Spindly and Bub3 in oral squamous cell carcinoma].

Purpose: To investigate the expression and significance of Spindly and Bub3 in oral squamous cell carcinoma(OSCC).

Methods: Sixty-five patients with OSCC admitted to the Fourth Hospital of Hebei Medical University from March 2017 to March 2019 were enrolled. RT-PCR was used to detect the expression of Spindly and Bub3 mRNA in oral squamous cell carcinoma and adjacent normal tissues from the patients.

Erratum: Tongxinluo inhibits neointimal formation by regulating the expression and post-translational modification of KLF5 in macrophages.

[This corrects the article on p. 4778 in vol. 8, PMID: 27904679.

Selective and sensitive visible-light-prompt photoelectrochemical sensor of paracetamol based on BiWO modified with Bi and copper sulfide.

Paracetamol (PA) is a ubiquitous non-steroidal anti-inflammatory drug, mainly used to treat headaches, arthritis and osteoarthritis and other diseases. In this work, a novel label free photoelectrochemical (PEC) sensor based on Bi-CuS/BiWO has been developed for the detection of PA, which was fabricated by a simple two-step hydrothermal process. It was found that Bi-CuS/BiWO with a CuS/BiWO heterojunction and surface plasmon resonance (SPR) effect of Bi possesses enhanced charge transfer and absorption wavelengths under visible light, particularly when compared to pristine BiWO films, thus producing an increase in the observed photocurrent.

Hemin-doped metal-organic frameworks based nanozyme electrochemical sensor with high stability and sensitivity for dopamine detection.

This study reports a new type of artificial nanozyme based on Hemin-doped-HKUST-1 (HKUST-1, also referred to as MOF-199; a face-centered-cubic MOF containing nanochannels) as a redox mediator for the detection of dopamine (DA). Hemin-doped-HKUST-1 was successfully synthesized by one-pot hydrothermal method, which was combined with reduced graphene oxide (rGO) modified on a glassy carbon electrode (GCE) to construct a sensor (Hemin-doped HKUST-1/rGO/GCE). The morphology and structure of Hemin-doped-HKUST-1 were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscope (TEM) and infrared spectra (IR) techniques.

Association of Level and Increase in D-Dimer With All-Cause Death and Poor Functional Outcome After Ischemic Stroke or Transient Ischemic Attack.

Background D-dimer is involved in poor outcomes of stroke as a coagulation biomarker. We aimed to investigate the associations of the level and increase in D-dimer between baseline and 90 days with all-cause death or poor functional outcome in patients after ischemic stroke or transient ischemic attack. Methods and Results We collected data from the CNSRIII (Third China National Stroke Registry) study.

Overexpression of lncRNA CASC2 inhibits the tumorigenesis of thyroid cancer via sponging miR-24-3p.

Background: The incidence of thyroid cancer continues to rise all over the world. Thus, it is urgent to find a novel strategy for the treatment of thyroid cancer. Previous reports have confirmed that lncRNA CASC2 is involved in the pathogenesis of thyroid cancer.

Suppression of lncRNA SNHG15 protects against cerebral ischemia-reperfusion injury by targeting miR-183-5p/FOXO1 axis.

Background: Cerebral ischemia/reperfusion (I/R) injury is a severe complication during the treatment of patients with stroke. It has been shown that the expression of SNHG15 was increased in patients with ischemic stroke (IS). However, the function and regulatory mechanism of SNHG15 in IS remains unclear.

[Expression level and effect of P2X7 receptor mRNA during osteogenic differentiation of human periodontal ligament stem cells].

Purspose: To investigate the role of P2X7 receptor in osteogenic differentiation of human periodontal ligament stem cells.

Methods: Human periodontal ligament stem cells obtained from primary culture were divided into 4 groups: control group, adenosine triphosphate group, osteogenic induction group, adenosine triphosphate + osteogenic induction group. The differences of RUNX2, OCN gene expression and P2X7 receptor mRNA expression between the four groups were compared.

Simultaneous determination of 11 antiseptic ingredients in surface water based on polypyrrole decorated magnetic nanoparticles.

With the emergence and spread of coronavirus COVID-19, the use of personal cleansing, medical and household disinfectant products have increased significantly. In this work, a new magnetic solid-phase extraction (MSPE) method for the determination of 11 antiseptic ingredients in surface water by high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) for 6 months based on FeO@PPy magnetic nanoparticles (MNPs) was established. The MSPE method possessed the advantages of simple processing, little time consumption and less organic solvent consumption, and the MNPs could be reused several times.