4,973 results match your criteria: "Heatstroke"

Article Synopsis
  • Active hemorrhage in cerebral hematomas is linked to blood leaking into brain tissue due to ruptured vessels and inflammation, worsening neurological conditions in intracerebral hemorrhage (ICH) cases.
  • High levels of heat shock protein 90 (HSP90) are found in ICH patients and are associated with increased inflammation, leading to deterioration of the blood-brain barrier (BBB).
  • Blocking HSP90 with specific drugs (Geldanamycin and radicicol) has shown promise in reducing inflammation, improving neurological health, and preventing further bleeding by protecting the BBB in ICH models.
View Article and Find Full Text PDF

Through the report of 4 cases of occupational heatstroke among sanitation workers working in high-temperature weather, this study analyzes the risk of occupational heatstroke among workers in the environmental sanitation industry working in high-temperature weather, and provides scientific suggestions for standardizing occupational health management, safeguarding the health rights and interests of workers, and preventing the occurrence of occupational heatstroke in summer. Through case analysis, we aim to raise high awareness of the occupational health of sanitation workers in the whole society, in order to provide a scientific and healthy working environment for sanitation workers and promote their physical and mental health.

View Article and Find Full Text PDF

Climate Change Projections for Stroke Incidence in Taiwan: Impact of 2 °C and 4 °C Global Warming Level.

J Epidemiol Glob Health

September 2024

National Institute of Environmental Health Sciences, National Health Research Institutes, No. 35, Keyan Rd., Zhunan Township, Miaoli County, 350401, Taiwan, ROC.

Objectives: This study aimed to establish the exposure-lag-response effect between daily maximum temperature and stroke-related emergency department visits and to project heat-induced stroke impacts under global warming levels (GWL) of 2 °C and 4 °C.

Methods: Stroke-related emergency department visits in Taiwan from 2001 to 2020 were identified using the National Health Insurance Research Database (NHIRD). The study population consisted of 1,100,074 initial stroke cases matched with 2,200,148 non-stroke controls.

View Article and Find Full Text PDF

Objective: To investigate the role of Parkin overexpression-induecd mitophagy in alleviating acute lung injury of exertional heat stroke(EHS) rats.

Methods: Eighty SD rats were divided into four groups: Control group (CON group), Control Parkin overexpression group (CON + Parkin group), exertional heat stroke group (EHS group), and exertional heat stroke Parkin overexpression group (EHS + Parkin group). Adeno-associated virus carrying the Parkin gene was intravenously injected into the rats to overexpress Parkin in the lung tissue.

View Article and Find Full Text PDF

APTT and D-dimer as biomarkers for heatstroke in patients with severe heat-related illnesses.

Medicine (Baltimore)

August 2024

Department of Blood Transfusion, Suining Central Hospital, Sichuan, Suining, PR China.

The objective of this study was to analyze the changes of activated partial thromboplastin time (APTT) and D-dimer in severe heatstroke (HS) patients and their value in identifying HS patients and to analyze clinical features and early laboratory test results of heat-related illnesses. Forty-five patients with heat-related illnesses who were admitted to the Department of Emergency and Intensive Care Medicine of Suining Central Hospital from June 2022 to April 2023 were retrospectively analyzed. Patients were divided into 3 groups based on their clinical diagnosis: classic HS group, exertional HS group, and control group.

View Article and Find Full Text PDF

Heatstroke death identification using ATR-FTIR spectroscopy combined with a novel multi-organ machine learning approach.

Spectrochim Acta A Mol Biomol Spectrosc

January 2025

Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China. Electronic address:

With global warming, the number of deaths due to heatstroke has drastically increased. Nevertheless, there are still difficulties with the forensic assessment of heatstroke deaths, including the absence of particular organ pathological abnormalities and obvious traces of artificial subjective assessment. Thus, determining the cause of death for heatstroke has become a challenging task in forensic practice.

View Article and Find Full Text PDF
Article Synopsis
  • Research highlights that the accuracy of clinical prognoses for survival after moderate to severe traumatic brain injury (TBI) is crucial since many patients die due to withdrawal of life-sustaining therapy based on assumed poor outcomes.
  • The study's objective was to evaluate if the automated measurement of cerebral contusion size and location can enhance the IMPACT score, a current prognostic model that doesn’t account for where brain injuries occur.
  • Conducted in 18 US trauma centers, the study assessed adult patients with moderate or severe TBI using an AI tool, BLAST-CT, to analyze CT scans, focusing on how contusion characteristics relate to long-term recovery outcomes using tools like the Glasgow Outcome Scale.
View Article and Find Full Text PDF
Article Synopsis
  • Exertional heat stroke (EHS) is a serious condition that requires quick cooling to avoid health issues, with a recommended cooling rate of 0.15°C/min.
  • A case report on a 22-year-old man shows that after initial cooling, he faced rebound hyperthermia, leading to the use of endovascular cooling (EVC) for effective temperature regulation.
  • This case highlights the importance of immediate cooling in EHS and suggests a need for specific EVC protocols for cases with rebound hyperthermia.
View Article and Find Full Text PDF

The physiological consequences of environment-induced heat stress (EIHS), caused by prolonged exposure to excess heat and humidity, are largely unknown. The purpose of this investigation was to determine the extent to which EIHS alters cardiac health. We hypothesized that 24 h of EIHS would cause cardiac injury and cellular dysfunction in a murine EIHS model.

View Article and Find Full Text PDF

Association between Heat Vulnerability Index and Stroke Severity.

Int J Environ Res Public Health

August 2024

Northwell Health, New Hyde Park, NY 11040, USA.

Background: Socioeconomically disadvantaged neighborhoods are particularly vulnerable to heat-related illnesses. We aim to investigate the association between the heat vulnerability index (HVI), an established neighborhood-level metric of heat-related mortality risk, and acute ischemic stroke (AIS) severity.

Methods: We conducted a retrospective analysis of consecutive AIS admissions to a comprehensive stroke center between 2012 and 2021.

View Article and Find Full Text PDF

Recent decades of epidemiological and clinical research have suggested that heat exposure could be a potential risk factor for ischemic stroke. Despite climate factors having a minor impact on individuals compared with established risk factors such as smoking, their widespread and persistent effects significantly affect public health. The mechanisms by which heat exposure triggers ischemic stroke are currently unclear.

View Article and Find Full Text PDF

Atherosclerosis is a condition that is associated with lipid accumulation in the arterial intima. Consequently, the enlarging lesion, which is also known as an atherosclerotic plaque, may close the blood vessel lumen, thus leading to organ ischaemia. Furthermore, the plaque may rupture and initiate the formation of a thrombus, which can cause acute ischaemia.

View Article and Find Full Text PDF

Objective: This study aimed to investigate the dynamic changes in the platelets of patients with severe heatstroke and the impact of these changes on the occurrence of disseminated intravascular coagulation (DIC) and prognosis in them.

Methods: This retrospective cohort study conducted at two tertiary hospitals recruited 264 patients with severe heatstroke. Logistic regression was used to analyze the association between platelet counts and DIC.

View Article and Find Full Text PDF

Exertional Heat Stroke Best Practices in U.S. Emergency Medical Services Guidelines.

J Emerg Med

October 2024

Korey Stringer Institute, Department of Kinesiology, University of Connecticut, Storrs, Connecticut. Electronic address:

Background: Exertional heat illnesses (EHIs), specifically exertional heat stroke (EHS), are a top cause of nonaccidental death among U.S. laborers.

View Article and Find Full Text PDF

Objectives: In the face of escalating global aridification, this study examines the complex relationship between climate variability, air pollution, natural disasters, and the prevalence of cardiovascular disease (CVD) and diabetes mellitus (DM) in arid regions.

Methods: The study conducted a scoping review of multiple databases using JBI guidelines and included 74 studies.

Results: The results show that acute myocardial infarction (n = 20) and stroke (n = 13) are the primary CVDs affected by these factors, particularly affecting older adults (n = 34) and persons with hypertension (n = 3).

View Article and Find Full Text PDF

Purpose: Cold water immersion (CWI) is the most effective treatment for exertional heat stroke (EHS). However, knowledge on core temperature response during CWI treatment and the relation with patient characteristics (i.e.

View Article and Find Full Text PDF

The fluctuation of the quantum Otto engine has recently received a lot of attention, while applying the many body with a long-range interaction to a quantum heat engine may enhance our ability of controlling it. Using the two-point measurement and its generalization, we explore the fluctuation theorem of work and heat in a single stroke as well as in a cycle. We discover that the fluctuations of work in a cycle as well as fluctuations of heat in a single stroke or cycle can be connected to the fluctuation of work in a single stroke.

View Article and Find Full Text PDF

Introduction/purpose: The purpose of this study was to test the hypothesis that cardiovascular (CV) drift and associated decrements in maximal oxygen uptake (V̇O 2max ) are greater in high-fit compared with low-fit women during exercise at the same %V̇O 2max , but comparable at the same rate of metabolic heat production.

Methods: Six high-fit (HI) and six low-fit (LO) women cycled in 35°C for 15 or 45 min at the same relative intensity (60% V̇O 2max ; 15REL and 45REL) or fixed rate of heat production (500 W; 15FX and 45FX), immediately followed by a graded exercise test to measure V̇O 2max . The separate 15- and 45-min trials permitted measurements of V̇O 2max over the same time interval as CV drift.

View Article and Find Full Text PDF

Heat vulnerability: health impacts of heat on older people in urban and rural areas in Europe.

Wien Klin Wochenschr

September 2024

Academy for Ageing Research, Haus der Barmherzigkeit, Vienna, Austria.

Exposure to extreme heat is associated with both increased morbidity and mortality, especially in older people. Health burdens associated with heat include heat stroke, diabetes mellitus, hypertension, ischemic heart diseases, heart failure and arrhythmia, pulmonary diseases but also injuries, problems with activities of daily living, and mental disorders. In Europe, there are remarkable spatial differences in heat exposure between urban and less populated areas.

View Article and Find Full Text PDF

Improved Public Health Messaging on Exertional Heat Stroke.

J Occup Environ Med

November 2024

From the Aerospace and Occupational Medicine, United States Air Force, Washington, DC (J.B.); Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts (J.B., K.N., K.S., B.A.); Center for Climate, Health, and the Global Environment (C-CHANGE), Harvard T.H. Chan School of Public Health Boston, Massachusetts (K.N.), La Isla Network, Washington, DC (J.G.); and Department of Community Medicine, Dartmouth Geisel School of Medicine, Hanover, New Hampshire (K.S.).

View Article and Find Full Text PDF

The objective was to assess if post-exercise ingestion of carbonated water in a hot environment ameliorates hypotension, enhances cerebral blood flow and heat loss responses, and positively modulates perceptions and mood states. Twelve healthy, habitually active young adults (five women) performed 60 min of cycling at 45% peak oxygen uptake in a hot climate (35°C). Subsequently, participants consumed 4°C carbonated or non-carbonated (control) water (150 and 100 mL for males and females regardless of drink type) at 20 and 40 min into post-exercise periods.

View Article and Find Full Text PDF

Heat acclimation alleviates the heat stress-induced impairment of vascular endothelial cells.

Tissue Cell

October 2024

Department of Otolaryngology Head & Neck Surgery/Deep Underground Space Medical Center, West China Hospital, Sichuan University, No. 37 Guoxuexiang, Chengdu, China; State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering, Sichuan University, No.24, south Section 1, 1st ring road, Chengdu, China; Med-X Center for Manufaturing, Sichuan University, No.24, south Section 1, 1st ring road, Chengdu, China. Electronic address:

Article Synopsis
  • Heat acclimation (HA) significantly reduces the risk of heat-related illnesses and enhances the resilience of vascular endothelial cells following heat stress, as shown by improved cell viability and decreased cell apoptosis in various cell types.
  • In this study, endothelial cells were subjected to HA and then exposed to higher temperatures, revealing that HA-pretreated cells exhibited increased expression of protective proteins and improved cellular functions compared to non-pretreated cells.
  • The research suggests that HA not only benefits vascular endothelial cells during heat exposure but also protects vital organs in mice, with the protective effects linked to an increase in HSP70 levels.
View Article and Find Full Text PDF

Nattokinase (NK), a potent serine endopeptidase, has exhibited a variety of pharmacological effects, including thrombolysis, anti-inflammation, and antioxidative stress. Building on previous research highlighting NK's promise in nerve regeneration, our study investigated whether NK exerted protective effects in transient middle cerebral artery occlusion (tMCAO)-induced cerebral ischemia-reperfusion injury and the underlying mechanisms. The rats were administered NK (5000, 10000, 20000 FU/kg, i.

View Article and Find Full Text PDF

Early-onset epilepsy following ischemic stroke is a severe neurological condition, the pathogenesis of which remains incompletely understood. Recent studies suggest that Neural stem/progenitor cells (NSPCs) play a crucial role in the disease process, yet the precise molecular mechanisms regulating NSPCs have not been thoroughly investigated. This study utilized single-cell transcriptome sequencing and bioinformatics analysis to identify disease-related genes, which were subsequently validated in both in vitro and in vivo experiments.

View Article and Find Full Text PDF

Background And Objective: Exertional heatstroke (EHS) mainly occurs in healthy young people with rapid onset and high mortality. EHS immune disorders can cause systemic inflammatory responses and multiple organ failure; however, the underlying mechanisms remain unclear. As high mobility group box 1 (HMGB1) is a prototypical alarmin that activates inflammatory and immune responses, this study aimed to investigate the effect and mechanism of HMGB1 in the pathogenesis of EHS.

View Article and Find Full Text PDF