9 results match your criteria: "Heart Research Institute Ltd[Affiliation]"

Background: Although the prognostic implications of severe mitral regurgitation (MR) are well recognised, they are less clear in moderate MR. We therefore explored the prognostic impact of both moderate and severe MR within the large National Echocardiography Database Australia cohort.

Methods: Echocardiography reports from 608 570 individuals were examined using natural language processing to identify MR severity and leaflet pathology.

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  • The study investigates the prevalence and impact of pulmonary hypertension (PHT) in adults with left ventricular diastolic dysfunction (LVDD) and preserved ejection fraction, using a large database of 16,058 patients.
  • Findings indicate that nearly 84% of subjects had some form of PHT, correlating higher tricuspid regurgitation velocity (TRV) levels with increased mortality rates over 1 and 5 years.
  • The research highlights that the risk of death increases significantly with higher TRV levels, establishing a clear prognostic relationship between PHT severity and mortality, particularly noted at TRV levels above 2.9 m/s.
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  • - The study aimed to examine how a 'mitral-specific' cardiac damage score (m-CDS) relates to survival outcomes in patients with mitral regurgitation (MR) and compared it with an 'aortic-specific' cardiac damage score (a-CDS) using data from a large Australian database.
  • - Out of over 620,000 adults analyzed through echocardiography, about 17,658 (3.1%) had moderate or severe MR, and a subset of 5,000 patients was tested to evaluate the effectiveness of various CDS models in predicting all-cause mortality over an average follow-up of 3.8 years.
  • - The research revealed that higher m-CDS stages were linked to
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Introduction: Digital health technologies have the potential to provide cost-effective care to remote and underserved populations. To realise this potential, research must involve people not traditionally included. No research focuses on the acceptability and feasibility of older Indigenous people using wearables for early atrial fibrillation (AF) detection.

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Objective: We developed an artificial intelligence decision support algorithm (AI-DSA) that uses routine echocardiographic measurements to identify severe aortic stenosis (AS) phenotypes associated with high mortality.

Methods: 631 824 individuals with 1.08 million echocardiograms were randomly spilt into two groups.

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Objective: Pulmonary hypertension (PHT) commonly coexists with significant mitral regurgitation (MR), but its prevalence and prognostic importance have not been well characterised. In a large cohort of adults with moderate or greater MR, we aimed to describe the prevalence and severity of PHT and assess its influence on outcomes.

Methods: In this retrospective study, we analysed the National Echocardiography Database of Australia (data from 2000 to 2019).

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Objective: Aortic regurgitation (AR) can lead to pulmonary hypertension (PHT). There is a paucity of data on the prognostic importance of PHT in these patients. We therefore aimed to describe the prevalence and prognostic importance of PHT in such patients.

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Objective: The significance of pulmonary hypertension (PHT) complicating aortic stenosis (AS) is poorly characterised. In a large cohort of adults with at least moderate AS, we aimed to describe the prevalence and prognostic importance of PHT in such patients.

Methods: In this retrospective study, we analysed the National Echocardiography Database of Australia (data from 2000 to 2019).

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The S100 protein CP-10 (chemotactic protein, 10 kD), a potent chemotactic factor for murine and human polymorphonuclear cells (PMN) and murine monocytes, has been purified in small amounts from supernatants of activated murine spleen cells (Lackmann et al., 1992). To obtain a more abundant source of the protein, CP-10 was expressed in Escherichia coli as a fusion protein with glutathione S-transferase (GST).

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