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Silencing HIF-1α aggravates non-alcoholic fatty liver disease in vitro through inhibiting PPAR-α/ANGPTL4 singling pathway.
Gastroenterol Hepatol
May 2021
Yan'an Hospital Affiliated to Kunming Medical University, Yunnan Cardiovascular Hospital, Key Laboratory of Cardiovascular Disease of Yunnan Province, Heart Disease Clinical Medical Center of Yunnan Province, Elderly Cardiovascular Disease Technology Innovation Team of Kunming, Key Laboratory of Cancer immunodeficiency of Yunnan Province, Kunming, Yunnan, PR. China. Electronic address:
Objective: Non-alcoholic fatty liver disease (NAFLD) is an aberrant lipid metabolism disease. Hypoxia inducible factor-1 (HIF-1α) is a transcription factor which plays an important part in adapting lower oxygen condition. Here, we aimed to clarify the relationship between HIF-1α and NAFLD.
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