Comparative Efficacy and Safety of Different Low-Dose Platelet Inhibitors in Patients With Coronary Heart Disease: A Bayesian Network Meta-Analysis.

Objective: The optimal low-dose antiplatelet agents in patients with coronary heart disease (CHD) had not been determined. The objective of this study was to compare the impact of different low-dose antiplatelet agents on cardiovascular outcomes and bleeding risks in patients with CHD.

Methods: We searched PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, VIP, WanFang Data, and China Biology Medicine.

a novel typing gene offering enhanced resolution for pandemic species.

The gene , encoding the mannitol transporter subunit IICBA of the phosphotransferase system, was the core gene with the greatest variability in and could be used as a new typing marker in . To expand its application, we performed an evolutionary analysis and found that the gene was present in nine phyla, 371 genera, and 1,662 species of bacteria. It is commonly found in pathogenic species of , followed by , , etc.

Current insights and challenges in the management of perifoveal vascular anomalous complex (PVAC): a systematic review of multimodal imaging features and treatment strategies.

The aim of this article is to comprehensively review the multimodal imaging (MMI) features that define perifoveal vascular anomalous complex (PVAC) and to update the optimal treatment strategies for this disorder with a focus also on the underlying pathogenetic mechanisms. This systematic review was performed based on a search of the PubMed and Embase databases of relevant papers on the subject of PVAC. PVAC is characterized by well-defined MMI findings, including remarkable morphological features with optical coherence tomography (OCT) and OCT angiography (OCTA).

Engagement of general practice preceptors in teaching residents in outpatient settings in China: a national cross-sectional study.

Background: Outpatient training is crucial for the standardized residency training of General Practitioners (GPs) in China. However, there is concern that General Practice (GP) preceptors may lack the willingness and capacities to teach residents in outpatient settings. Understanding how GP preceptors practice routine outpatient training and their views is essential for designing strategies; however, this issue has not been well studied.

Efficacy and Safety of Prehospital Blood Transfusion in Traumatized Patients: A Systematic Review and Meta-Analysis.

Background: Approximately five million individuals have traumatic injuries annually. Implementing prehospital blood-component transfusion (PHBT), encompassing packed red blood cells (p-RBCs), plasma, or platelets, facilitates early hemostatic volume replacement following trauma. The lack of uniform PHBT guidelines persists, relying on diverse parameters and physician experience.

General obesity, abdominal obesity, and the risk of cardiovascular disease including stroke in 5-year breast cancer survivors.

Background: To assess the association between discrepancies between general obesity and abdominal obesity and the risk of subsequent cardiovascular disease (CVD), including stroke, in breast cancer survivors.

Methods: We undertook a retrospective cohort study using data from the National Health Insurance Service of South Korea. Among 72,174 5-year breast cancer survivors aged 40 years and above, body mass index (BMI) and waist circumference (WC) were used to determine obesity status.

Rationalizing hydrogel-integrated peroxidase-mimicking nanozymes for combating drug-resistant bacteria and colorimetric sensing.

Due to the easy preparation, high stability and environmental friendliness, nanozymes are frequently used as promising substitutes to natural enzymes. However, the efficacy of nanozymes in biomedicine aspects is often hampered by their potential biotoxicity and limited bioavailability, which prompted structure adaption or carrier design to maximize nanozymes performance. Despite considerable efforts on carriers to deliver nanozymes efficiently, the systematic studies on enzyme-like activities of nanozymes related to platforms of nanozyme@carrier are sparse.

Pentosan polysulfate sodium maculopathy: Final analysis of a prospective cohort, updated review, and association with inflammatory bowel disease.

Pentosan polysulfate sodium (PPS) maculopathy is a recently described condition of macular toxicity. We report the prevalence (15%), the clinical characteristics, and the multimodal imaging (MMI) features of PPS maculopathy based on a final prospective analysis of a cohort of 154 subjects and highlight the association with inflammatory bowel disease (IBD). In addition, we summarize the most recent and relevant literature on PPS maculopathy.

Telehealth memory clinics in primary healthcare: real-world experiences from low-resource settings in Greece.

Background: The role of primary healthcare is pivotal in the management of the surge of dementia prevalence particularly in low-resource areas. In this study, two telehealth-based memory clinics in primary healthcare operating within the frames of the INTegRated InterveNtion of pSychogerIatric Care (INTRINSIC) are presented.

Methods: The first clinic, which is led by a general practitioner, operates at a primary healthcare center in a semi-mountainous area and closely collaborates with the geriatric psychiatry outpatient clinic of the Patras University General Hospital via a telehealth medicine platform.

Brachial-Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low-Risk Population.

Background: Recent studies have suggested that increased brachial-ankle pulse wave velocity (baPWV) is a risk factor for diabetes. Exploring its relationship with insulin resistance is of interest, necessitating further studies across different sexes and age groups.

Methods And Results: This cohort study involved 119 170 Korean adults with an average age of 39.

Development and pilot evaluation of an evidence-based algorithm for MASLD (formerly NAFLD) management in primary care in Europe.

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), emerges as major cause of morbidity and mortality globally, with chronic patients facing increased risk. Guidelines on MASLD management in primary care (PC) are limited. This study aimed to develop and evaluate a clinical care pathway for use in PC to improve MASLD screening and management, including early detection, communication and treatment, in three European countries (Greece, Spain, the Netherlands).

Necessity of Analyzing the Korea Community Health Survey Using 7 Local Government Types.

Objectives: This study examined the potential of a new analytical framework for the Korea Community Health Survey (KCHS) with classification criteria for the sub-national governmental level, the degree of urbanization including an urban-rural multimodal category, and population size as a more effective tool to address local health problems and deduce practical implications.

Methods: Retrospective survey data from 2023 KCHS were obtained. Frequency analyses were performed for self-rated good health status, current smoking status, and unmet medical needs as proxies for health status, as well as healthcare utilization and health behavior, utilizing individual weights to represent national community residents.

The Impact of COVID-19 on Admissions and In-hospital Mortality of Patients with Stroke in Korea: An Interrupted Time Series Analysis.

Objectives: This study aimed to investigate the impact of COVID-19 on admission rates and in-hospital mortality among patients with ischemic and hemorrhagic stroke.

Methods: We constructed a dataset detailing the monthly hospitalizations and mortality rates of inpatients with stroke from January 2017 to December 2021. Employing an interrupted time series analysis, we explored the impact of COVID-19 on hospitalizations and 30-day in-hospital mortality among stroke patients.

Combating tumor PARP inhibitor resistance: Combination treatments, nanotechnology, and other potential strategies.

PARP (poly (ADP-ribose) polymerase) inhibitors (PARPi) have demonstrated significant potential in cancer treatment, particularly in tumors with breast cancer susceptibility gene (BRCA) mutations and other DNA repair deficiencies. However, the development of resistance to PARPi has become a major challenge in their clinical application. The emergence of drug resistance leads to reduced efficacy of the PARPi over time, impacting long-term treatment outcomes and survival rates.

A Case Report on Management of Liver Cirrhosis Using Ayurveda and Integrative Approach of Treatment.

Liver cirrhosis is an advanced stage of abnormal fibrogenesis of tissues that causes liver injuries. Though cirrhosis can be managed by etiological parameters, its long-term reversal is still a question. Ayurveda system of medicine diagnoses liver disease under "Kamala" and "Udara" with promising outcomes of treatment.

Obesity Stigma Among Healthcare Workers in a Teaching Hospital in Saudi Arabia.

Background: Obesity is a significant public health issue in Saudi Arabia. Rising obesity rates increase the risk of weight bias and stigma, even among healthcare workers.

Objectives: This study assesses weight stigma in healthcare workers, with findings intended to inform strategies for creating a more supportive healthcare environment for patients with obesity.

Cross-sectional personal network analysis of adult smoking in rural areas.

Research on smoking behaviour has primarily focused on adolescents, with less attention given to middle-aged and older adults in rural settings. This study examines the influence of personal networks and sociodemographic factors on smoking behaviour in a rural Romanian community. We analysed data from 76 participants, collected through face-to-face interviews, including smoking status (non-smokers, current and former smokers), social ties and demographic details.

Evolutionary mechanisms that promote cooperation may not promote social welfare.

Understanding the emergence of prosocial behaviours among self-interested individuals is an important problem in many scientific disciplines. Various mechanisms have been proposed to explain the evolution of such behaviours, primarily seeking the conditions under which a given mechanism can induce highest levels of cooperation. As these mechanisms usually involve costs that alter individual pay-offs, it is, however, possible that aiming for highest levels of cooperation might be detrimental for social welfare-the latter broadly defined as the total population pay-off, taking into account all costs involved for inducing increased prosocial behaviours.

Improving the accuracy of reporting Ki-67 IHC by using an AI tool.

Ki-67 proliferative index (PI) scoring is measured by estimating the proportion of the number of active cell nuclei in hotspot regions within immunohistochemical (IHC) stained slides. It provides valuable information about the rate of proliferation in a tumour. Manual scoring of Ki-67 PI is laborious, time-consuming and often the victim of interobserver variability between pathologists.