645 results match your criteria: "Health Sciences Center at Houston[Affiliation]"

Primary Care Screening for Nonalcoholic Fatty Liver Disease Among People With HIV in the United States: A Real-World Provider Survey.

J Assoc Nurses AIDS Care

December 2024

Jennifer C. Price, MD, PhD, is a Professor, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA. Kyoko Hirose, BA, is a Research Coordinator, Division of Gastroenterology and Hepatology, University of California San Francisco, San Francisco, California, USA. Naga Chalasani, MD, is a Professor, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Holly Crandall, RN, BSN, CCRP, is a Project Manager, Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Sonya Heath, MD, is a Professor, Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA. Rohit Loomba, MD MHSc, is a Professor, Division of Gastroenterology and Hepatology, University of California, San Diego, California, USA. Susanna Naggie, MD, is a Professor, Duke Clinical Research Institute, Duke University, Durham, North Carolina, USA. Richard K. Sterling, MD, MSc, is a Professor, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Virginia, USA. Mark Sulkowski, MD, is a Professor, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Laura Wilson, ScM, is a Senior Research Associate, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. Jordan E. Lake, MD, MSc, is an Associate Professor, Division of Infectious Disease, University of Texas Health Sciences Center at Houston, Houston, Texas, USA.

Nonalcoholic fatty liver disease (NAFLD) is highly prevalent in people with HIV (PWH) and increases the risk of hepatic fibrosis and hepatocellular carcinoma. We sent an online survey to providers of the American Academy of HIV Medicine. Of respondents (n = 214, 8% response rate), 65% reported screening for NAFLD in PWH, with 28% routinely screening all patients.

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The Woven EndoBridge (WEB) device has become a prominent treatment for wide-neck bifurcation intracranial aneurysms since its FDA approval in 2018. However, the impact of anticoagulant therapy on its efficacy and patient outcomes remains underexplored. This study aims to evaluate the effects of postoperative anticoagulant use on aneurysm occlusion, retreatment rates, and functional outcomes following WEB device implantation.

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Use of cannabis and alcohol were common during pregnancy and the first year postpartum among people with HIV in the United States (2007-2019), but there were no major differences in substance use during pregnancy based on mode of HIV acquisition. The relatively high prevalence of substance use in this population, particularly postpartum alcohol and cannabis use, warrants further attention.

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Legionella pneumophila is a potentially life-threatening infection, especially for individuals with compromised cell-mediated immunity. Typical chest CT findings include multilobed or multisegmented consolidations and ground-glass opacities, but cavitary lesions are rare. This case report details a 29-year-old male renal transplant recipient who developed cavitary Legionnaires' pneumonia.

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Background: We used a social network approach to identify influential community organizations within integrated public health networks in three regions in Texas, US: Houston/Harris County, Cameron County, and Northeast Texas. The study aimed to understand how network structures influence organizational performance in COVID-19 response.

Methods: In collaboration with community partners in each region, we administered a snowball sampling network data collection.

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Background: Spetzler-Martin (SM) Grade III brain arteriovenous malformations (BAVMs) represent a transitional risk zone between low- and high-grade BAVMs, characterized by diverse angioarchitecture. The primary treatment options are endovascular embolization, microsurgical resection (MS), and stereotactic radiosurgery (SRS). This study compares the efficacy and outcomes of MS and SRS.

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Depletion of Adipose Stroma-Like Cancer-Associated Fibroblasts Potentiates Pancreatic Cancer Immunotherapy.

Cancer Res Commun

January 2025

Center for Metabolic and Degenerative Diseases, The Brown Foundation Institute of Molecular Medicine for the Prevention of Disease, McGovern Medical School, Houston, Texas.

This study shows that populations of CAFs have distinct effects on pancreatic cancer progression and shows that depletion of CAFs expressing adipose markers potentiates tumor/metastasis suppression effects of immune checkpoint blockade.

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Objective: 8-30 % of patients who present with aneurysmal subarachnoid hemorrhage (aSAH) have multiple intracranial aneurysms (MIA). Although prompt treatment to secure ruptured aneurysms (RA) is standard of care, there is no clear consensus regarding whether incidental unruptured aneurysms (UA) should be treated during the same procedural time as the RA. This study aims to examine the effect of treatment of UA during the same procedural time as treatment for the RA (concurrent treatment) versus delaying the treatment of an UA after discharging the patient (delayed treatment).

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Non-bacterial thrombotic endocarditis: a clinical and pathophysiological reappraisal.

Eur Heart J

November 2024

Department of Cardiology, University of Texas Health Sciences Center, MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

Non-bacterial thrombotic endocarditis (NBTE), formerly recognized as marantic endocarditis, represents a rare cardiovascular pathology intricately linked with hypercoagulable states, notably malignancy and autoimmune disorders. Characterized by the development of sterile vegetations comprised of fibrin and platelets on cardiac valves, NBTE poses a diagnostic challenge due to its resemblance to infective endocarditis. Therapeutic endeavours primarily revolve around addressing the underlying aetiology and instituting anticoagulant regimens to forestall embolic events, with surgical intervention seldom warranted.

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Purpose: Chronic pain is common among people with spinal cord injury (PwSCI) and impacts mental health (MH). Mindfulness may buffer the association of pain with MH, but few studies have examined this among PwSCI. This study examines the extent to which mindfulness moderates the association of pain intensity with MH among PwSCI.

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Article Synopsis
  • ACJ disruption is common in athletes but understanding the biomechanics and treatment effects (surgery vs. nonoperative) on shoulder movement remains limited due to insufficient measurement techniques.
  • This study aimed to use dynamic stereo x-ray (DSX) imaging to analyze ACJ movement, comparing outcomes between surgically reconstructed shoulders, nonoperatively treated shoulders, and their uninjured counterparts.
  • A controlled laboratory study was conducted with participants who had unilateral ACJ surgeries, assessing movement, range of motion, and strength using advanced imaging and statistical methods.
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Article Synopsis
  • The study investigated heritage bilinguals, a significant yet underexplored bilingual group in the U.S., by analyzing data from eight MRI studies involving 215 heritage Spanish-English bilinguals and 145 English monolinguals.
  • It found that bilinguals with higher Spanish proficiency had less volume in certain brain areas, while better English skills and earlier exposure to English were linked to increased volume in other areas of the brain.
  • The findings indicate a connection between brain structure and second language learning, suggesting future research should focus on how these brain adaptations occur during language development.
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Purpose: The topical administration of spironolactone, a mineralocorticoid receptor antagonist (MRA) improves dry eye symptoms in patients with ocular graft-versus-host disease (GVHD); however, the detailed mechanism remains unclear. This study aimed to investigate the effects of spironolactone eyedrops on the ocular surface using a chronic GVHD (cGVHD) mouse model and to determine the expression of the mineralocorticoid receptor (MR).

Methods: A cGVHD mouse model was established by allogeneic bone marrow transplantation (BMT) from B10.

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Adverse childhood experiences in adults with chronic traumatic brain injury: Support for a life course approach to brain injury rehabilitation.

Disabil Health J

January 2025

TIRR Memorial Hermann, Houston, TX, USA; Department of Physical Medicine and Rehabilitation, UT Health Sciences Center at Houston, Houston, TX, USA.

Article Synopsis
  • Adverse childhood experiences (ACEs) can increase the risk of experiencing adult traumatic brain injury (TBI) and affect recovery outcomes, but research on this is limited.
  • A study involving 85 individuals with chronic TBI examined the prevalence of both household (conventional) and community-level ACEs and found significant associations with mental health symptoms and overall quality of life.
  • The findings suggest that those with higher ACEs reported worse mental health and quality of life, highlighting the importance of considering ACEs in TBI treatment and research approaches.
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Clinical decision support systems (CDSS) are routinely employed in clinical settings to improve quality of care, ensure patient safety, and deliver consistent medical care. However, rule-based CDSS, currently available, do not feature reusable rules. In this study, we present CDSS with reusable rules.

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Background: Arteriovenous malformations (AVMs) are uncommon cerebral lesions that can cause significant neurological complications. Surgical resection is the gold standard for treatment, but endovascular embolization and stereotactic radiosurgery (SRS) are viable alternatives.

Objective: To compare the outcomes of endovascular embolization versus SRS in the treatment of AVMs with Spetzler-Martin grades I-III.

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Ventricular fibrillation arrest in aortic dissection presenting as myocardial injury.

Radiol Case Rep

December 2024

University of Missouri Kansas City, School of Medicine, Kansas City, MO, USA.

Article Synopsis
  • * The study discusses a case involving a 61-year-old man who experiences sudden chest pain and suffers a ventricular fibrillation arrest before being diagnosed with aortic dissection.
  • * The report highlights how aortic dissection can mimic acute myocardial injury and emphasizes the importance of using specific models to help differentiate it from acute coronary syndromes during diagnosis.
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Cognitive Performance is Associated With 1-Year Participation and Life Satisfaction Outcomes: A Traumatic Brain Injury Model Systems Study.

J Head Trauma Rehabil

September 2024

Author Affiliations: Department of Neurology (Drs Gilmore, Healy, Edlow and Bodien), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts; Center for Neurotechnology and Neurorecovery (Drs Gilmore, Edlow, and Bodien), Biostatistics Center (Dr Healy), Massachusetts General Hospital, Boston, Massachusetts; Mayo Clinic College of Medicine and Science (Dr Bergquist), Departments of Physical Medicine and Rehabilitation and Psychiatry and Psychology (Dr Bergquist), Mayo Clinic, Rochester, Minnesota; Department of Physical Medicine and Rehabilitation (Drs Bogner and Corrigan), College of Medicine, The Ohio State University, Columbus, Ohio; Department of Rehabilitation and Human Performance (Drs Dams-O'Connor and Kumar), Department of Neurology (Dr Dams-O'Connor), Icahn School of Medicine at Mount Sinai, New York, New York; Department of Ophthalmology and Visual Sciences & Physical Medicine and Rehabilitation (Dr Dreer), Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; Brain Injury Research Center (Dr Juengst), TIRR Memorial Hermann, Houston, Texas; Department of Physical Medicine and Rehabilitation (Dr Juengst), UT Health Sciences Center at Houston, Houston, Texas; Department of Physical Medicine and Rehabilitation (Drs O'Neil-Pirozzi, Giacino, and Bodien), Spaulding Rehabilitation Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Communication Sciences and Disorders (Dr O'Neil-Pirozzi), Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts; Departments of Physical Medicine & Rehabilitation and Neuroscience (Dr Wagner), Clinical and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania; and Athinoula A. Martinos Center for Biomedical Imaging (Dr Edlow), Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

Article Synopsis
  • This study aimed to explore how cognitive changes following inpatient rehabilitation impact participation and life satisfaction one year later for individuals with traumatic brain injury (TBI).
  • The analysis included 499 participants from a larger dataset, focusing on their performance in cognitive assessments (BTACT) at discharge and one year post-injury.
  • Results indicated that while changes in episodic memory were linked to better participation and life satisfaction outcomes, changes in executive function did not show a significant association once controlled for other factors.
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The Effectiveness and Safety of Stellate Ganglion Block in the Treatment of Symptoms from Long COVID-19: A Pilot Study.

Psychopharmacol Bull

August 2024

Lin, MD, University of Texas Health Sciences Center at Houston, McGovern Medical School, Department of Physical Medicine and Rehabilitation, Houston, TX, USA.

Article Synopsis
  • A pilot study was conducted to assess the safety and effectiveness of stellate ganglion blocks for treating long COVID symptoms in 17 patients.
  • Before and after the procedure, patients completed surveys measuring various symptoms, revealing that 94% experienced moderate-to-severe autonomic dysfunction prior to treatment, but all reported symptom improvement post-procedure.
  • Results indicated significant reductions in fatigue and heart rate, while changes in anxiety and PTSD scores were not statistically significant, suggesting that stellate ganglion blocks could be a useful adjunctive therapy for some long COVID patients.
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Background: A wealth of clinically relevant information is only obtainable within unstructured clinical narratives, leading to great interest in clinical natural language processing (NLP). While a multitude of approaches to NLP exist, current algorithm development approaches have limitations that can slow the development process. These limitations are exacerbated when the task is emergent, as is the case currently for NLP extraction of signs and symptoms of COVID-19 and postacute sequelae of SARS-CoV-2 infection (PASC).

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"The unbearable lightness" of the primary end point in clinical trials.

Mol Cell Biochem

August 2024

Center for Cardiovascular Genetics, Institute of Molecular Medicine and Department of Medicine, University of Texas Health Sciences Center at Houston, 6770 Bertner Street, Suite C900A, Houston, TX, 77030, USA.

In this Perspective, I discuss the limitations of a soft primary endpoint that is used in some of the recent randomized phase II/III clinical trials. Unfortunately, many clinicians and investigators do not interpret the data critically to recognize the limitations of such findings. I advise against over-interpreting the effects of an intervention on a soft primary endpoint.

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One overlooked result in a 1989 paper on the "cycle of violence" was a race-specific increase in risk for arrest for violence among Black maltreated children, but not White maltreated children. We examine whether race differences in the cycle of violence are explained by risk factors traditionally associated with violence. Using a prospective design, maltreated and non-maltreated children were matched on age, sex, race, and approximate family social class and interviewed at mean age 28.

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A Directed Content Analysis for Greatest Problems Among People With and Without Traumatic Brain Injury.

Arch Phys Med Rehabil

August 2024

Department of Physical Medicine & Rehabilitation, UT Southwestern Medical Center, Dallas; Brain Injury Research Center, TIRR Memorial Hermann, Houston; Department of Physical Medicine & Rehabilitation, University of Texas Health Sciences Center at Houston, Houston, TX.

Objective: To characterize the greatest problem or need among individuals with a history of traumatic brain injury (TBI), as compared with individuals with a history of other neurologic conditions, mental health conditions, and no history of neurologic or mental health conditions.

Design: A directed content analysis of open-text responses to a single online survey question using a framework guided by the Mayo-Portland Adaptability Inventory-4.

Setting: Community.

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Myelodysplastic syndrome, or myelodysplastic neoplasms, are a rare finding in pediatric, adolescent, and young adult (AYA) patients. More literature is needed to highlight trends of survival or treatment resistance in subpopulations to improve treatment. Here we report a single center retrospective analysis of pediatric and AYA patients from 2000 to 2022 including molecular and cytogenetic data.

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